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David W Scott, PhD
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Journal Articles

Suppression of FVIII Antibody Production By FVIII BAR T-Cell in Vitro in the Presence of Inhibitors

Kalpana Parvathaneni, PhD, Ai-Hong Zhang, PhD, David W. Scott, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3789.
https://doi.org/10.1182/blood-2018-99-115278
Published: 2018
Journal Articles

Human Treg Can Suppress Th17 Inflammatory Cytokine Secretion Independent of IL-2 Deprivation

Patrick Adair, Kalpana Parvathaneni, PhD, Yong Chan Kim, PhD, David W. Scott, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3792.
https://doi.org/10.1182/blood-2018-99-115329
Published: 2018
Journal Articles

Apoptotic Blocks in Primary Non-Hodgkin B-Cell Lymphomas Identified By BH3 Profiling

Nathalie A Johnson, MD PhD, Claudia M Wever, PhD, Dominique Geoffrion, BSc, Ghassemian Artin, MD, Brailovski Eugene, Pierre Sesques, MD, Jeremy A. Ryan, SM, Liliana Stoica, Josee Hebert, MD, Tina Petrogiannis-Haliotis, MD PhD, Svetlana Dmitrienko, MD PhD, Frenkiel Saul, MD, German Ott, MD, Annette Staiger, Christian Steidl, MD, David W. Scott, PhD MD, FRACP, FRCPA, Koren Kathleen Mann, PhD, Anthony Letai, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4126.
https://doi.org/10.1182/blood-2018-99-118225
Published: 2018
Journal Articles

Factor VIII BAR T-Cell Recognition By Antibodies to Different Domains

Kalpana Parvathaneni, PhD, Katherine Pohida, B.S., David W. Scott, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1171.
https://doi.org/10.1182/blood-2018-99-113375
Published: 2018
Journal Articles

Obinutuzumab Plus Gemcitabine, Dexamethasone and Cisplatin (O-GDP) As Salvage Chemotherapy Prior to Autologous Stem Cell Transplant in Aggressive B Cell Lymphoma

Michael D. Jain, MD PhD, Ryan D. Morin, PhD BSc, MSc, Anca Prica, MD, Vishal Kukreti, MD, Robert Kridel, PhD MD, Rob C. Laister, PhD, Li Meng, Christopher Rushton, BSc, Miguel Alcaide, PhD, Rashmi S. Goswami, BSc, MD PhD FRCPC, Jan M.A. Delabie, MD PhD, Jessica Weiss, Tony Panzarella, M.Sc., P.Stat, Michael Crump, MD, David W. Scott, PhD MD, FRACP, FRCPA, John Kuruvilla, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4610.
https://doi.org/10.1182/blood-2018-99-117333
Published: 2018
Journal Articles

UBR5 Mutations in Mantle Cell Lymphoma Lead to Increased Proliferation through a Cyclin D1-Dependent Mechanism

Olga Kutovaya, PhD, Stacy Hung, Elena Viganò, PhD, Adele Telenius, Bruce W Woolcock, Barbara Meissner, PhD, Shane Colborne, BSc, Randy D. Gascoyne, MD, Diego Villa, MD, Ryan D. Morin, PhD, BSc, MSc, David W. Scott, PhD MD, FRACP, FRCPA, Gregg B Morin, PhD, Christian Steidl, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2849.
https://doi.org/10.1182/blood-2018-99-118524
Published: 2018
Journal Articles

Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 As a Therapeutic Target for Restoring MHC Expression in Diffuse Large B-Cell Lymphoma

Daisuke Ennishi, MDPhD, Katsuyoshi Takata, MD PhD, Wendy Béguelin, PhD, Gerben Duns, PhD, Anja Mottok, Pedro Farinha, MD PhD, Ali Bashashati, David Scott, Merrill Boyle, BSc, Barbara Meissner, PhD, Susana Ben-Neriah, BSc, Bruce W Woolcock, Adele Telenius, Daniel Lai, Matthew R Teater, PhD, Robert Kridel, PhD MD, Kerry J Savage, BSc, MD MSc, Laurie H Sehn, MD MPH, Ryan D. Morin, PhD BSc MSc, Marco A. Marra, PhD, Sohrab P Shah, Joseph M. Connors, MD, Randy D. Gascoyne, MD, David W. Scott, PhD MD FRACP FRCPA, Ari M Melnick, MD, Christian Steidl, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1560.
https://doi.org/10.1182/blood-2018-99-112010
Published: 2018
Journal Articles

Targeting FVIII-Specific B Cells Using BAR-Transduced Regulatory T Cells

Ai-Hong Zhang, PhD, Jeong Heon Yoon, PhD, Yong Chan Kim, PhD, David W. Scott, PhD
Journal: Blood
Blood (2016) 128 (22): 329.
https://doi.org/10.1182/blood.V128.22.329.329
Published: 2016
Journal Articles

FVIII-Specific TCR Engineered Human Regulatory T Cells Suppress the Production of FVIII-Specific Responses Vitro and In Vivo

Yong Chan Kim, PhD, Aihong Zhang, MS, PhD, Jeong-Heon Yoon, PhD, David W. Scott, PhD
Journal: Blood
Blood (2016) 128 (22): 2586.
https://doi.org/10.1182/blood.V128.22.2586.2586
Published: 2016
Journal Articles

Neither Factor VIII Nor the Putative F8B Protein Is Detectable in Human Peripheral Blood Mononuclear Cells

Devi Gunasekera, MBBS, Kenneth B. Lewis, PhD, Alexis A. Thompson, MD, Ronald R, Louie, MD, David W. Scott, PhD, Kathleen P. Pratt, PhD
Journal: Blood
Blood (2015) 126 (23): 3507.
https://doi.org/10.1182/blood.V126.23.3507.3507
Published: 2015
Journal Articles

Engineered FVIII-Specific Human T-Effector Cells: Can the T-Cell Receptor Modulate CD4 + T-Helper Phenotypes or Is It Just a “Switch”?

Patrick Adair, Yong Chan Kim, PhD, Kathleen P. Pratt, PhD, David W Scott, PhD
Journal: Blood
Blood (2014) 124 (21): 1417.
https://doi.org/10.1182/blood.V124.21.1417.1417
Published: 2014
Journal Articles

Generation and Characterization of FVIII-Specific CAR-Transduced Regulatory T Cells

Anja Naumann, Yongchan Kim, PhD, Christoph Königs, MD PhD, David W Scott, PhD
Journal: Blood
Blood (2014) 124 (21): 236.
https://doi.org/10.1182/blood.V124.21.236.236
Published: 2014
Journal Articles

Targeting FVIII Expression to Platelets Induces Immune Tolerance in Hemophilia A Mice with or without Pre-Existing Anti-FVIII Immunity,

Yingyu Chen, PhD, Erin L. Kuether, Jocelyn A. Schroeder, Robert R. Montgomery, MD, David W. Scott, PhD, Qizhen Shi, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 4170.
https://doi.org/10.1182/blood.V118.21.4170.4170
Published: 2011
Journal Articles

B-Cell Depletion Using IgG1 Anti-CD20 Spares MZ B Cells and Promotes Tolerance to Human FVIII In a Murine Model of Hemophilia A

Ai-Hong Zhang, Ph.D., Jonathan Skupsky, PhD, David W. Scott, PhD
Journal: Blood
Blood (2010) 116 (21): 2206.
https://doi.org/10.1182/blood.V116.21.2206.2206
Published: 2010
Journal Articles

De-Immunization of Immunodominant HLA-DR Epitopes In the C2 Domain of Factor VIII

Chang Song, PhD, Leonard Moise, Ph.D., Ryan Tassone, Elizabeth McClaine, William D. Martin, Annie S. DeGroot, M.D., David W. Scott, PhD
Journal: Blood
Blood (2010) 116 (21): 2207.
https://doi.org/10.1182/blood.V116.21.2207.2207
Published: 2010
Journal Articles

Tolerance Induced by B-Cell Gene Therapy: Expansion and Increased Activity of Antigen-Specific Tregs.

Jonathan Skupsky, BS, Yan Su, Ph.D, David W. Scott, PhD
Journal: Blood
Blood (2009) 114 (22): 2129.
https://doi.org/10.1182/blood.V114.22.2129.2129
Published: 2009
Journal Articles

Effect of B-Cell Depletion On Inhibitor Antibody Formation and Immune Tolerance Induction to Human Factor VIII in Hemophilia A Mice.

Ai-Hong Allan Zhang, MS, PhD, Jonathan Skupsky, BS, David W. Scott, PhD
Journal: Blood
Blood (2009) 114 (22): 2137.
https://doi.org/10.1182/blood.V114.22.2137.2137
Published: 2009
Journal Articles

Immunogenicity of FVIII: a Role for Thrombin.

Jonathan Skupsky, BS, Ai-Hong Allan Zhang, MS, PhD, David W. Scott, PhD
Journal: Blood
Blood (2009) 114 (22): 3175.
https://doi.org/10.1182/blood.V114.22.3175.3175
Published: 2009
Journal Articles

Induction of ‘Tolerance’ in a T-Cell Clone from a Mild Hemophilia Patient

David W. Scott, PhD, Elizabeth Kadavil, MSc, Ai-Hong Zhang, MS, PhD, Ruth A. Ettinger, PhD, Kathleen Pratt, PhD
Journal: Blood
Blood (2008) 112 (11): 3526.
https://doi.org/10.1182/blood.V112.11.3526.3526
Published: 2008
Journal Articles

Unraveling the Danger Signal Necessary for the Immune Response to Therapeutic Factor VIII.

Jonathan Skupsky, BS, Ai-Hong Zhang, MS, PhD, David W. Scott, PhD
Journal: Blood
Blood (2008) 112 (11): 1220.
https://doi.org/10.1182/blood.V112.11.1220.1220
Published: 2008