1-11 of 11
David M. Spencer, PhD
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Regulated Natural Killer Cell Expansion and Anti-Tumor Activity with Inducible MyD88/CD40

Xiaomei Wang, PhD, Wei-Chun Chang, PhD, Daniel L. Jasinski, PhD, Jan L. Medina, BS, Ming Zhang, BS, Aaron Foster, PhD, David M. Spencer, PhD, J. Henri Bayle, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4550.
https://doi.org/10.1182/blood-2018-99-120151
Published: 2018
Journal Articles

Characterization of Allogeneic T Cells Expressing Inducible Caspase-9 Following Adoptive Transfer in Children Receiving an HLA-Haploidentical Hematopoietic Stem Cell Transplant for the Treatment of Myeloid Malignancies

Joanne Shaw, PhD, Xiaoou Zhou, MD PhD, An Lu, Valentina Bertaina, Daria Pagliara, MD PhD, Melissa Aldinger, PharmD, David M. Spencer, PhD, Franco Locatelli, Aaron Foster, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4534.
https://doi.org/10.1182/blood-2018-99-119779
Published: 2018
Journal Articles

Differential Expression of Inducible Caspase-9 (iC9) in Allogeneic T Cells Allows Selective Depletion of Activated T Cells Following Exposure to Rimiducid and Permits In Vivo Allodepletion

Xiaoou Zhou, MD PhD, An Lu, Kelly L Sharp, Margie Harris, Madhavi Anumula, MS, J. Bayle, PhD, David M. Spencer, PhD, Aaron Foster, PhD, Joanne Shaw, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3496.
https://doi.org/10.1182/blood-2018-99-119285
Published: 2018
Journal Articles

Inducible MyD88/CD40 (iMC) Enhances Proliferation and Survival of Tumor-Specific TCR-Modified T Cells and Improves Anti-Tumor Efficacy in Myeloma

Tsvetelina Pentcheva-Hoang, PhD, David Torres, Tania Rodriguez, PhD, Ana Korngold, PhD, An Lu, Jeannette Crisostomo, Annemarie Moseley, MD PhD, Lorenz Jahn, Mirjam H.M. Heemskerk, PhD, Kevin M Slawin, MD, David M Spencer, PhD, Aaron E Foster, PhD
Journal: Blood
Blood (2016) 128 (22): 4550.
https://doi.org/10.1182/blood.V128.22.4550.4550
Published: 2016
Journal Articles

Inducible MyD88/CD40 (iMC) Costimulation Provides Ligand-Dependent Tumor Eradication By CD123-Specific Chimeric Antigen Receptor T Cells

Aaron E Foster, PhD, MyLinh Duong, PhD, An Lu, Peter Chang, PhD, Aruna Mahendravada, Nicholas Shinners, PhD, Kevin M Slawin, MD, J. Henri Bayle, PhD, David M Spencer, PhD
Journal: Blood
Blood (2016) 128 (22): 4551.
https://doi.org/10.1182/blood.V128.22.4551.4551
Published: 2016
Journal Articles

Inducible MyD88/CD40 Enhances Proliferation and Survival of PRAME-Specific TCR-Engineered T Cells and Increases Anti-Tumor Effects in Myeloma

Tsvetalina Hoang, PhD, Aaron Foster, PhD, Jeannette Crisostomo, An Lu, Annemarie Moseley, MDPhD, Mirjam H.M. Heemskerk, PhD, Kevin M Slawin, MD, David M Spencer, PhD
Journal: Blood
Blood (2015) 126 (23): 1886.
https://doi.org/10.1182/blood.V126.23.1886.1886
Published: 2015
Journal Articles

Inducible MyD88/CD40 Allows Rimiducid-Dependent Activation to Control Proliferation and Survival of Chimeric Antigen Receptor-Modified T Cells

Aaron Foster, PhD, Aruna Mahendravada, Nicholas P Shinners, PhD, Peter Chang, PhD, An Lu, Eva Morschl, PhD, Joanne Shaw, PhD, Sunandan Saha, PhD, Kevin M Slawin, MD, David M Spencer, PhD
Journal: Blood
Blood (2015) 126 (23): 4295.
https://doi.org/10.1182/blood.V126.23.4295.4295
Published: 2015
Journal Articles

Expression of MyD88/CD40 Drives In Vivo Activation and Proliferation of Chimeric Antigen Receptor-Modified T Cells That Can be Effectively Regulated By Inducible Caspase-9

Aaron Foster, PhD, Peter Chang, PhD, Pei-Yi Lin, PhD, Jeannette Crisostomo, Aruna Mahendravada, An Lu, Mariam Khalil, Sunandan Saha, PhD, Joanne Shaw, PhD, Eva Morschl, PhD, Kevin M Slawin, MD, David M Spencer, PhD
Journal: Blood
Blood (2015) 126 (23): 851.
https://doi.org/10.1182/blood.V126.23.851.851
Published: 2015
Journal Articles

Genetic Modification of Multi Leukemia Antigen-Specific Cytotoxic T Lymphocytes (CTL) to Enhance In Vivo Safety and Persistency

Fabian Zohren, MD, Maria R Imperato, Anurathapan Usanarat, MD, David M Spencer, PhD, Helen E. Heslop, MD, Malcolm K. Brenner, MB, PhD, FRCP, FRCPath, Cliona M. Rooney, PhD, Ann M. Leen, PhD, Juan F Vera, MD, Ulrike Gerdemann, MD
Journal: Blood
Blood (2011) 118 (21): 644.
https://doi.org/10.1182/blood.V118.21.644.644
Published: 2011
Journal Articles

CASPALLO: Phase I Clinical Trial of Allodepleted T Cells Transduced with Inducible Caspase 9 Suicide Gene After Haploidentical Stem Cell Transplantation

Antonio Di Stasi, MD, Siok K Tey, MD, Yuriko Fujita, MD, Russell Cruz, MD, Alana Kennedy-Nasser, MD, Caridad Martinez, MD, Stephen M Gottschalk, MD, Karin Straathof, MD, Enli Liu, April Durett, Bambi J Grilley, Hao Liu, PhD, Barbara Savoldo, MD, Yvon Eric, PhD, Teresita Lopez, Oumar Diouf, Adrian P. Gee, PhD, John Schindler, PhD, Catherine M Bollard, MD, Robert A Krance, MD, David M Spencer, PhD, Cliona M Rooney, PhD, Helen E Heslop, MD, Gianpietro Dotti, MD, Malcolm K Brenner, MB, PhD, FRCP, FRCPath
Journal: Blood
Blood (2010) 116 (21): 559.
https://doi.org/10.1182/blood.V116.21.559.559
Published: 2010
Journal Articles

Inducible Caspase 9 as a Safety Switch in Genetically Modified Cytotoxic T Cells.

Karin C. Straathof, MD, Martin A. Pule, MD, Patricia Yotnda, PhD, Gianpietro Dotti, MD, Elio F. Vanin, PhD, Malcolm K. Brenner, MD, PhD, Helen E. Heslop, MD, PhD, David M. Spencer, PhD, Cliona M. Rooney, PhD
Journal: Blood
Blood (2004) 104 (11): 1743.
https://doi.org/10.1182/blood.V104.11.1743.1743
Published: 2004