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Darren J Newton, PhD
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Journal Articles

Extravascular Hemolysis Due to C3-Loading in Patients with PNH Treated with Eculizumab: Defining the Clinical Syndrome

Claire E McKinley, BSc, Stephen John Richards, PhD FRCPath, Talha Munir, Morag Griffin, Lindsay D Mitchell, MBChB, MRCP(UK), FRCPath, Louise Arnold, Kathryn Riley, Nicola Copeland, Darren J Newton, PhD, Anita Hill, MBChB (Hons), PhD, Peter Hillmen, MBChB, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3471.
https://doi.org/10.1182/blood.V130.Suppl_1.3471.3471
Published: 2017
Journal Articles

Fibrinogen and Clot Structure Is Affected By Eculizumab in Patients with Paroxysmal Nocturnal Haemoglobinuria

Fraser Macrae, BSc, PhD, Polly Bowman, Emma Linton, Barnaby Peacock-Young, Deborah Clarke, MSc, Darren J Newton, PhD, Claire E McKinley, BSc, Kathryn Riley, Nicola Copeland, Louise Arnold, Morag Griffin, Talha Munir, Peter Hillmen, MBChB, PhD, Stephen John Richards, PhD FRCPath, Robert Ariens, BSc, PhD, Anita Hill, MBChB (Hons), PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 462.
https://doi.org/10.1182/blood.V130.Suppl_1.462.462
Published: 2017
Journal Articles

Assessment of Eculizumab and C5 Levels in PNH Treatment: Molar Ratio of Eculizumab to C5 Level Effectively Predicts Ongoing Dosage Changes in a Cohort of 50 Patients Treated with Eculizumab

Darren J Newton, PhD, Claire E McKinley, BSc, Alonso Ricardo, PhD, Michelle D Hoarty, PhD, Louise Arnold, Kathryn Riley, Nicola Copeland, Talha Munir, Morag Griffin, Anita Hill, MBChB (Hons), PhD, Peter Hillmen, MBChB, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3484.
https://doi.org/10.1182/blood.V130.Suppl_1.3484.3484
Published: 2017
Journal Articles

“Red Cell Complement Loading In PNH Patients On Eculizumab Is Associated With a C3 Polymorphism Which Influences C3 Function, Predicts For Increased Extravascular Hemolysis and Provides a Rationale For C3 Inhibition.”

Praveen Kaudlay, MBBS, MRCP, Haiying Hua, MD, Guansheng He, MD, Darren J Newton, PhD, Abraham M Varghese, MB ChB, Talha Munir, MBBS, MRCP, FRCPath, Anita Hill, MBChB, PhD, Richard J Kelly, MBChB, Stephen John Richards, PhD, Peter Hillmen, MB ChB, PhD
Journal: Blood
Blood (2013) 122 (21): 2466.
https://doi.org/10.1182/blood.V122.21.2466.2466
Published: 2013