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Journal Articles

PI3Kδ/AKT Inhibition Augments 2-Phenylethynesulfonamide Induced Apoptosis Via the Unfolded Protein Response in Chronic Lymphocytic Leukemia

Matthew D Blunt, PhD, Lindsay D Smith, PhD, Adam Linley, PhD BSc, Jonathan C Strefford, PhD, Peter Johnson, Francesco Forconi, MD DM, PhD FRCPath, Freda K. Stevenson, DPhil, Graham Packham, PhD, Andrew J Steele, PhD

Blood (2017) 130 (Supplement 1): 4290.

https://doi.org/10.1182/blood.V130.Suppl_1.4290.4290

Published: 2017

Journal Articles

Regulation and Impact of BCR Induced Autophagy in Chronic Lymphocytic Leukemia

Lindsay D Smith, PhD, Laura I Karydis, PhD, Margaret Ashton-Key, MD, Jonathan C Strefford, PhD, Freda K. Stevenson, DPhil, Graham Packham, PhD, Mark Cragg, PhD, David A Tumbarello, PhD, Matthew D Blunt, PhD, Francesco Forconi, MD DM, PhD FRCPath, Andrew J Steele, PhD

Blood (2017) 130 (Supplement 1): 1717.

https://doi.org/10.1182/blood.V130.Suppl_1.1717.1717

Published: 2017

Journal Articles

Regulation of B-Cell Receptor Signalling By the Tumour Microenvironment in Chronic Lymphocytic Leukemia (CLL) and Its Impact on Adhesion and miRNA Expression

Matthew D Blunt, PhD, Rachel Dobson, BSc(Hons), Lindsay D Smith, PhD, Jonathan C. Strefford, Pamela B. Conley, PhD, Anjali Pandey, PhD, Andrew J Davies, FRCP PhD, Peter M Johnson, MA, MD, Graham Packham, PhD, Freda K Stevenson, DPhil, Francesco Forconi, MD DM, PhD FRCPath, Greg P Coffey, PhD, Andrew J Steele, PhD

Blood (2016) 128 (22): 351.

https://doi.org/10.1182/blood.V128.22.351.351

Published: 2016

Journal Articles

Chemical Activation of the SHIP1 Inositol Lipid Phosphatase: A Novel Therapeutic Strategy to Suppress B-Cell Receptor Signaling and CXCR4 Expression in Malignant Human B Cells

Graham Packham, PhD, Beatriz Valle-Argos, Elizabeth Lemm, Lindsay D Smith, PhD, Nicola J Weston-Bell, PhD, Yohannes Gebreselassie, Andrew J Steele, PhD, Freda K Stevenson, Mark S Cragg, PhD, Francesco Forconi, MD DM, PhD FRCPath, Jennifer Cross, Curtis Harwig, Lloyd Mackenzie

Blood (2016) 128 (22): 2037.

https://doi.org/10.1182/blood.V128.22.2037.2037

Published: 2016

Journal Articles

A Multi-Center Phase 1b, Open-Label, Dose-Finding Pilot Study to Evaluate the Combination of Carfilzomib and Cyclophosphamide with Dexamethasone (CCyD) Prior to Autologous Stem Cell Transplant (ASCT) in Patients with Transplant Eligible Newly Diagnosed Multiple Myeloma

William I. Bensinger, MD, Robert Vescio, MD, Cristina Gasparetto, MD, Elber S. Camacho, MD, Rajneesh Nath, MD, Christina L. Gomes, MD, David D. Smith, PhD, Jatin J. Shah, Brian G. M. Durie, MD

Blood (2014) 124 (21): 4739.

https://doi.org/10.1182/blood.V124.21.4739.4739

Published: 2014

Journal Articles

A Phase I Dose-Escalation Study of Carfilzomib in Patients with Previously-Treated Systemic Light-Chain (AL) Amyloidosis

Adam D. Cohen, MD, Emma C. Scott, MD, Michaela Liedtke, MD, Jonathan L. Kaufman, MD, Heather Landau, MD, David H. Vesole, MD PhD, Christina L. Gomes, MD, Cristina Gasparetto, MD, Suzanne Lentzsch, MD PhD, Michael Rosenzweig, MD, Vaishali Sanchorawala, MD, David D. Smith, PhD, Raymond L. Comenzo, MD, Brian G. M. Durie, MD

Blood (2014) 124 (21): 4741.

https://doi.org/10.1182/blood.V124.21.4741.4741

Published: 2014

Journal Articles

Phase I/II Dose Expansion Of a Multi-Center Trial Of Carfilzomib and Pomalidomide With Dexamethasone (Car-Pom-d) In Patients With Relapsed/Refractory Multiple Myeloma

Jatin J. Shah, M.D., Edward A. Stadtmauer, MD, Rafat Abonour, MD, Adam D. Cohen, MD, William Bensinger, MD, Cristina Gasparetto, MD, Jonathan L. Kaufman, MD, Suzanne Lentzsch, MD, PhD, Dan T. Vogl, MD, MSCE, Robert Z. Orlowski, M.D., Ph.D., Erica L. Kim, MPH, Natalia Bialas, David D. Smith, PhD, Brian GM Durie, MD

Blood (2013) 122 (21): 690.

https://doi.org/10.1182/blood.V122.21.690.690

Published: 2013

Journal Articles

Synergistic Killing of Leukemic Cells by Small Molecule Inhibitors of the Pim Protein Kinases and Inactivators of Additional Signal Transduction Pathways.

Yingwei Lin, MD, PhD, Zanna M Beharry, PhD., Elizabeth G Hill, Jin H. Song, Wenxue Wang, Zuping Xia, Zhenhua Zhang, Peter D. Aplan, MD, Jon Aster, MD, PhD, Charles D Smith, PhD, Andrew Kraft, MD

Blood (2009) 114 (22): 409.

https://doi.org/10.1182/blood.V114.22.409.409

Published: 2009

Journal Articles

Novel Small Molecule Pim Protein Kinase Inhibitors Induce Cell Cycle Arrest and Apoptosis in Human Leukemias: A Potential Therapeutic Approach.

Yingwei Lin, MD., Jin H. Song, PhD., Zhenhua Zhang, Peter D. Aplan, MD, Charles D Smith, PhD, Andrew Kraft, MD, Zanna M Beharry, PhD.

Blood (2008) 112 (11): 1632.

https://doi.org/10.1182/blood.V112.11.1632.1632

Published: 2008

Journal Articles

Final Report on Tandem Autologous Stem Cell Transplantation for Patients with Primary Progressive or Poor Risk Recurrent Hodgkin Lymphoma - A Two Institution Study.

Blood (2005) 106 (11): 2071.

https://doi.org/10.1182/blood.V106.11.2071.2071

Published: 2005

Journal Articles

Analysis of the X-Linked F-Cell Production Locus.

Jeffrey R. Keefer, MD, PhD, Shirley H. Purvis, MS, George J. Dover, MD, Kirby D. Smith, PhD

Blood (2005) 106 (11): 3178.

https://doi.org/10.1182/blood.V106.11.3178.3178

Published: 2005

Journal Articles

Pharmacological Therapy of Inherited Disease.

Jeffrey R. Keefer, MD, PhD, Martina C. McGuinness, PhD, Gao X. Dong, PhD, George J. Dover, MD, Kirby D. Smith, PhD

Blood (2005) 106 (11): 3179.

https://doi.org/10.1182/blood.V106.11.3179.3179

Published: 2005

NARROW

PI3Kδ/AKT Inhibition Augments 2-Phenylethynesulfonamide Induced Apoptosis Via the Unfolded Protein Response in Chronic Lymphocytic Leukemia

Regulation and Impact of BCR Induced Autophagy in Chronic Lymphocytic Leukemia

Regulation of B-Cell Receptor Signalling By the Tumour Microenvironment in Chronic Lymphocytic Leukemia (CLL) and Its Impact on Adhesion and miRNA Expression

Chemical Activation of the SHIP1 Inositol Lipid Phosphatase: A Novel Therapeutic Strategy to Suppress B-Cell Receptor Signaling and CXCR4 Expression in Malignant Human B Cells

A Multi-Center Phase 1b, Open-Label, Dose-Finding Pilot Study to Evaluate the Combination of Carfilzomib and Cyclophosphamide with Dexamethasone (CCyD) Prior to Autologous Stem Cell Transplant (ASCT) in Patients with Transplant Eligible Newly Diagnosed Multiple Myeloma

A Phase I Dose-Escalation Study of Carfilzomib in Patients with Previously-Treated Systemic Light-Chain (AL) Amyloidosis

Phase I/II Dose Expansion Of a Multi-Center Trial Of Carfilzomib and Pomalidomide With Dexamethasone (Car-Pom-d) In Patients With Relapsed/Refractory Multiple Myeloma

Synergistic Killing of Leukemic Cells by Small Molecule Inhibitors of the Pim Protein Kinases and Inactivators of Additional Signal Transduction Pathways.

Novel Small Molecule Pim Protein Kinase Inhibitors Induce Cell Cycle Arrest and Apoptosis in Human Leukemias: A Potential Therapeutic Approach.

Final Report on Tandem Autologous Stem Cell Transplantation for Patients with Primary Progressive or Poor Risk Recurrent Hodgkin Lymphoma - A Two Institution Study.

Analysis of the X-Linked F-Cell Production Locus.

Pharmacological Therapy of Inherited Disease.

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American Society of Hematology

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American Society of Hematology

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