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Journal Articles

Single Cell Immune Profiling Reveals Distinct T Cell Clones and Functional States in in-Vitro Expanded Cord Blood Derived Gamma Delta T Cells

Kar Wai Tan, PhD, Zhihui Li, Joey Lai, Dianyan Guo, Yeh Ching Linn, MBBS, MRCP, William YK Hwang, MBBS, Shang Li, MD PhD, Connie J. Eaves, PhD, Yeow Tee Goh, MBBS, Alice Cheung, PhD

Blood (2020) 136 (Supplement 1): 35–36.

https://doi.org/10.1182/blood-2020-140667

Published: 2020

Journal Articles

NUP98-HOXA9 -Initiates Molecular and Biologic Features of Disease Progression in a Humanized Model of CML

Ivan Sloma, PharmD, PhD, Philip Beer, PhD FRCPath, MRCP, Christophe Desterke, PhD, Elizabeth Bulaeva, Misha Bilenky, Michelle Moksa, Kamini Raghuram, Cedric Brimacombe, Karen Lambie, Ali G Turhan, MD PhD, Orianne Wagner-Ballon, MD PhD, Philippe Gaulard, MD PhD, R. Keith Humphries, MD PhD, Martin Hirst, PhD BS, Connie J. Eaves, PhD

Blood (2019) 134 (Supplement_1): 4139.

https://doi.org/10.1182/blood-2019-127839

Published: 2019

Journal Articles

Growth Factor-Dependent Activation of a MYC-Induced Latent AML Program in Human Hematopoietic Cells

Elizabeth Bulaeva, Davide Pellacani, PhD, Naoto Nakamichi, MD PhD, Philip Beer, MD PhD, Colin Hammond, Alireza Lorzadeh, Michelle Moksa, Annaick Carles, Misha Bilenky, Sylvain Lefort, PhD, Jeremy Shu, Brian T. Wilhelm, PhDBSc, Andrew P. Weng, MD PhD, Martin Hirst, PhD, Connie J. Eaves, PhD

Blood (2019) 134 (Supplement_1): 2533.

https://doi.org/10.1182/blood-2019-122768

Published: 2019

Journal Articles

Global Transcriptome Profiling Identifies a Key Mir-185-PAK6 Axis That Promotes Survival of Leukemic Stem Cells and Drug-Insensitive Blasts in BCR-ABL + Human Leukemia

Andrew Wu, BSc, Lin Hanyang, PhD, Katharina Rothe, PhD, Min Chen, MD PhD, Jens Ruschmann, PhD, Oleh Petriv, PhD, Kieran O'Neill, PhD, Tobias Maetzig, MD, David Knapp, PhD, Naoto Nakamichi, MD PhD, Ryan Brinkman, PhD, Inanc Birol, PhD, Donna L Forrest, MD, Carl Hansen, PhD, R. Keith Humphries, MD PhD, Connie J. Eaves, PhD, Xiaoyan Jiang, MD PhD

Blood (2018) 132 (Supplement 1): 931.

https://doi.org/10.1182/blood-2018-99-113559

Published: 2018

Journal Articles

Synthetic De Novo Modeling of Human T-Cell Acute Lymphoblastic Leukemia Reveals HOXB Genes Drive Expansion of Leukemia Cells-of-Origin and Established Tumor Clones

Blood (2018) 132 (Supplement 1): 1322.

https://doi.org/10.1182/blood-2018-99-120120

Published: 2018

Journal Articles

Genotypic Representation of Myelodysplastic/Myeloproliferative Neoplasms in Nrg, Nrg-3GS and Srg-W41 Mice with Transgenic Expression of Human Cytokines

Hein Than, MD FRCPath, MRCP, Naoto Nakamichi, MD PhD, Anthony D. Pomicter, MS, John O'Shea, PhD, Orlando Antelope, Thomas O'Hare, PhD, Connie J. Eaves, PhD, Michael W. Deininger, MD PhD

Blood (2018) 132 (Supplement 1): 2038.

https://doi.org/10.1182/blood-2018-99-111728

Published: 2018

Journal Articles

Single Cell-Resolution Analysis of HSC Dysfunction in Mir-146a knockout Mice

Jennifer Grants, PhD, Joanna Wegrzyn, PhD, David Knapp, PhD, Tony Hui, Kieran O'Neill, PhD, Jeremy Parker, PhD, Deborah Deng, Mark Boldin, PhD, Martin Hirst, PhD, Connie J. Eaves, PhD, Aly Karsan, MD

Blood (2017) 130 (Supplement 1): 714.

https://doi.org/10.1182/blood.V130.Suppl_1.714.714

Published: 2017

Journal Articles

The Focal Adhesion Complex Ilk-Pinch-Parvin Is Key to Niche Interactions and Survival of Quiescent Stem Cells in Chronic Myeloid Leukemia In Vitro and In Vivo

Katharina Rothe, PhD, Artem Babaian, Naoto Nakamichi, MD PhD, Min Chen, PhD, Akie Watanabe, Dixie Mager, PhD, Connie J. Eaves, PhD, Shoukat Dedhar, PhD, Xiaoyan Jiang, MD PhD

Blood (2016) 128 (22): 936.

https://doi.org/10.1182/blood.V128.22.936.936

Published: 2016

Journal Articles

Enhanced and Accelerated Repopulation of Mutant C-Kit Immunodeficient Mice By Transplants of Primary Chronic and Acute Myeloid Leukemic Human Cells

Naoto Nakamichi, MD PhD, Colin A. Hammond, Paul H. Miller, PhD, Katharina Rothe, PhD, Philip A Beer, BM, MRCP, MRCPath, Xiaoyan Jiang, MD PhD, Michael W. Deininger, MD PhD, Connie J. Eaves, PhD

Blood (2016) 128 (22): 4537.

https://doi.org/10.1182/blood.V128.22.4537.4537

Published: 2016

Journal Articles

Identification and Characterization of New Microrna Biomarkers and Target Genes in Drug-Insensitive CD34+ CML Stem/Progenitor Cells Using Global Comparative RNA-Seq Analyses

Hanyang Lin, BSc, MSc, Jonathan Zeng, Katharina Rothe, BSc, MSc, Jens Ruschmann, PhD, Oleh Petriv, PhD, Kieran O'Neill, PhD, Tobias Maetzig, PhD, David Knapp, BSc, Ryan R. Brinkman, PhD, Inanc Birol, PhD, Donna L. Forrest, MD, Carl Hansen, PhD, Connie J. Eaves, PhD, R. Keith Humphries, MD PhD, Xiaoyan Jiang, MDPhD

Blood (2015) 126 (23): 1567.

https://doi.org/10.1182/blood.V126.23.1567.1567

Published: 2015

Journal Articles

NOTCH1 Induces Differential Epigenomic Patterning and Genomic Organization in Fetal Liver- and Adult Bone Marrow-Derived Hematopoietic Progentiors

Vincenzo Giambra, PhD, Sonya H Lam, Miriam Belmonte, Sam Gusscott, Sohrab Salehi, Fong Chun Chan, Robert Kridel, MD MPH, Alireza Lorzadeh, Catherine Hoofd, PhD, Christian Steidl, MD, Connie J. Eaves, PhD, Martin Hirst, PhD, Andrew P. Weng, MD PhD

Blood (2015) 126 (23): 3637.

https://doi.org/10.1182/blood.V126.23.3637.3637

Published: 2015

Journal Articles

Longterm Multilineage Human Hematopoietic Repopulation of Untreated KIT-Mutant Immunodeficient Mice

Paul H. Miller, Gabrielle Rabu, David J.H.F. Knapp, Alice M.S. Cheung, PhD, Kiran Dhillon, Philip A. Beer, MRCP, FRCPath, PhD, Connie J. Eaves, PhD

Blood (2014) 124 (21): 2415.

https://doi.org/10.1182/blood.V124.21.2415.2415

Published: 2014

Journal Articles

Prior Granulocyte Colony-Stimulating Factor Treatment Enhances the Immediate and Transient Output of Primitive Hematopoietic Cells in the Blood of Normal Adult Human Donors Treated with Plerixafor

Paul H. Miller, Naoto Nakamichi, MDPhD, Gabrielle Rabu, Kirk R. Schultz, MD, David M. Jones, MD, Stephen Couban, MD FRCPC, Connie J. Eaves, PhD

Blood (2014) 124 (21): 5787.

https://doi.org/10.1182/blood.V124.21.5787.5787

Published: 2014

Journal Articles

Whole Genome Sequencing Of Chronic Myeloid Leukemia (CML)-Derived Induced Pluripotent Stem Cells (iPSC) Reveals Faithful Genocopying Of Highly Mutated Primary Leukemic Cells

Ivan Sloma, PharmD, PhD, Maria Teresa Mitjavila-Garcia, PhD, Olivier Feraud, Noufissa Oudrhiri, Lucie Tosca, PharmD, PhD, Sanaa El Marsafy, MD, PhD, Emilie Gobbo, Dominique Divers, Alexis Proust, Frank Griscelli, PharmD PhD, Gerard Tachdjian, MD, PhD, Marco A. Marra, PhD, Connie J Eaves, PhD, Annelise Bennaceur-Griscelli, MD, PhD, Ali G Turhan, MD, PhD

Blood (2013) 122 (21): 514.

https://doi.org/10.1182/blood.V122.21.514.514

Published: 2013

Journal Articles

A Novel TWIST2-ID2 Axis That Modulates The Growth and Imatinib Sensitivity Of CML CD34+ Cells

Yun Zhao, PhD, Wenjuan Ma, Xiuyan Zhang, Jiangxia Cui, Ivan Sloma, PhD, Haixia Zhou, Depei Wu, MD, Connie J Eaves, PhD

Blood (2013) 122 (21): 511.

https://doi.org/10.1182/blood.V122.21.511.511

Published: 2013

Journal Articles

Disruption Of Ikaros In Patients’ Chronic Phase CML Cells Induces The Features Of Accelerated Phase Disease

Philip A Beer, MRCP, FRCPath, PhD, Ivan Sloma, PhD, Paul H Miller, BAppSc, David JHF Knapp, BSc, Gabrielle Rabu, BSc, Connie J Eaves, PhD

Blood (2013) 122 (21): 513.

https://doi.org/10.1182/blood.V122.21.513.513

Published: 2013

Journal Articles

Fetal Vs. Adult Hematopoietic Progenitors Respond Differently to NOTCH1: Implications for Pediatric Vs. Adult T-ALL.

Vincenzo Giambra, PhD, Sonya H Lam, Amy Ng, Claudia Benz, PhD, Olena O Shevchuk, Connie J. Eaves, PhD, Andrew P Weng, MD, PhD

Blood (2012) 120 (21): 2381.

https://doi.org/10.1182/blood.V120.21.2381.2381

Published: 2012

Journal Articles

Short Term Signalling Responses of the Most Primitive Subsets of Human Hematopoietic Cells Stimulated in Vitro Correlate with Their Subsequent Self-Renewal Behaviour.

David J.H.F. Knapp, Sean C. Bendall, PhD, Paul H. Miller, Alice M.S. Cheung, PhD, Suzan Imren, MD, R. Keith Humphries, MD, PhD, Ryan R. Brinkman, Robert A.J. Oostendorp, BSc, MSc, PhD, Garry P. Nolan, PhD, Connie J. Eaves, PhD

Blood (2012) 120 (21): 2341.

https://doi.org/10.1182/blood.V120.21.2341.2341

Published: 2012

Journal Articles

Time Course Studies of the Progeny of Barcoded CD34 + Human Cord Blood Cells Generated in Transplanted NOD/SCID-IL2Rγ −/− Mice Unveil the Clonal Dynamics of Short Term, Intermediate Term and Long Term Repopulating Cells

Alice M.S. Cheung, PhD, Long V. Nguyen, Annaick Carles, Paul H. Miller, Philip A Beer, BM, MRCP, MRCPath, Pawan Pandoh, David Knapp, Kiran Dhillon, Kane Tse, Thomas Zeng, Yongjun Zhao, Martin Hirst, Ph.D., Connie J. Eaves, PhD

Blood (2012) 120 (21): 28.

https://doi.org/10.1182/blood.V120.21.28.28

Published: 2012

Journal Articles

Longterm Serial Transplantability of BCR-ABL+ Chronic Phase CML Cells Is Predicted by a 6-Week LTC-IC Assay.

Ivan Sloma, PharmD, PhD, Philip A Beer, BM, MRCP, MRCPath, Kyi Min Saw, Matthiew Chan, Karen Lambie, Bobby Johnston, Xiaoyan Jiang, MD, PhD, Connie J. Eaves, PhD

Blood (2012) 120 (21): 2770.

https://doi.org/10.1182/blood.V120.21.2770.2770

Published: 2012

NARROW

Single Cell Immune Profiling Reveals Distinct T Cell Clones and Functional States in in-Vitro Expanded Cord Blood Derived Gamma Delta T Cells

NUP98-HOXA9 -Initiates Molecular and Biologic Features of Disease Progression in a Humanized Model of CML

Growth Factor-Dependent Activation of a MYC-Induced Latent AML Program in Human Hematopoietic Cells

Global Transcriptome Profiling Identifies a Key Mir-185-PAK6 Axis That Promotes Survival of Leukemic Stem Cells and Drug-Insensitive Blasts in BCR-ABL + Human Leukemia

Synthetic De Novo Modeling of Human T-Cell Acute Lymphoblastic Leukemia Reveals HOXB Genes Drive Expansion of Leukemia Cells-of-Origin and Established Tumor Clones

Genotypic Representation of Myelodysplastic/Myeloproliferative Neoplasms in Nrg, Nrg-3GS and Srg-W41 Mice with Transgenic Expression of Human Cytokines

Single Cell-Resolution Analysis of HSC Dysfunction in Mir-146a knockout Mice

The Focal Adhesion Complex Ilk-Pinch-Parvin Is Key to Niche Interactions and Survival of Quiescent Stem Cells in Chronic Myeloid Leukemia In Vitro and In Vivo

Enhanced and Accelerated Repopulation of Mutant C-Kit Immunodeficient Mice By Transplants of Primary Chronic and Acute Myeloid Leukemic Human Cells

Identification and Characterization of New Microrna Biomarkers and Target Genes in Drug-Insensitive CD34+ CML Stem/Progenitor Cells Using Global Comparative RNA-Seq Analyses

NOTCH1 Induces Differential Epigenomic Patterning and Genomic Organization in Fetal Liver- and Adult Bone Marrow-Derived Hematopoietic Progentiors

Longterm Multilineage Human Hematopoietic Repopulation of Untreated KIT-Mutant Immunodeficient Mice

Prior Granulocyte Colony-Stimulating Factor Treatment Enhances the Immediate and Transient Output of Primitive Hematopoietic Cells in the Blood of Normal Adult Human Donors Treated with Plerixafor

Whole Genome Sequencing Of Chronic Myeloid Leukemia (CML)-Derived Induced Pluripotent Stem Cells (iPSC) Reveals Faithful Genocopying Of Highly Mutated Primary Leukemic Cells

A Novel TWIST2-ID2 Axis That Modulates The Growth and Imatinib Sensitivity Of CML CD34+ Cells

Disruption Of Ikaros In Patients’ Chronic Phase CML Cells Induces The Features Of Accelerated Phase Disease

Fetal Vs. Adult Hematopoietic Progenitors Respond Differently to NOTCH1: Implications for Pediatric Vs. Adult T-ALL.

Short Term Signalling Responses of the Most Primitive Subsets of Human Hematopoietic Cells Stimulated in Vitro Correlate with Their Subsequent Self-Renewal Behaviour.

Time Course Studies of the Progeny of Barcoded CD34 + Human Cord Blood Cells Generated in Transplanted NOD/SCID-IL2Rγ −/− Mice Unveil the Clonal Dynamics of Short Term, Intermediate Term and Long Term Repopulating Cells

Longterm Serial Transplantability of BCR-ABL+ Chronic Phase CML Cells Is Predicted by a 6-Week LTC-IC Assay.

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American Society of Hematology

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American Society of Hematology

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