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Journal Articles

A Bank of CD30.CAR-Modified, Epstein-Barr Virus-Specific T Cells That Lacks Host Reactivity and Resists Graft Rejection for Patients with CD30-Positive Lymphoma

David H. Quach, PhD, Haran R. Ganesh, BS, Sachin Thakkar, PhD, Luis Becerra-Dominguez, BS, Birju Mehta, MS, Silvana Perconti, MS, Eric Anderson, BS, Emily M. Hsieh, MD, Olga Dakhova, MD, Huimin Zhang, BS, Bambi J. Grilley, RPh, Malcolm K. Brenner, MD PhD, Helen E. Heslop, MD DSc, Carlos A. Ramos, MD, Rayne H. Rouce, MD, Natalia Lapteva, PhD, Cliona M. Rooney, PhD

Blood (2020) 136 (Supplement 1): 16.

https://doi.org/10.1182/blood-2020-141491

Published: 2020

Journal Articles

CD70-Specific CAR T Cells Have Potent Activity Against Acute Myeloid Leukemia (AML) without HSC Toxicity

Tim Sauer, MD, Kathan Parikh, Sandhya Sharma, Bilal Omer, MD, Stephen Gottschalk, MD, Cliona M. Rooney, PhD

Blood (2019) 134 (Supplement_1): 1932.

https://doi.org/10.1182/blood-2019-125534

Published: 2019

Journal Articles

CD30-Chimeric Antigen Receptor (CAR) T Cells for Therapy of Hodgkin Lymphoma (HL)

Carlos A. Ramos, MD, Mrinalini Bilgi, Claudia P. Gerken, Olga Dakhova, Zhuyong Mei, Bambi J. Grilley, RPh, Adrian P. Gee, PhD, Cliona M. Rooney, PhD, Gianpietro Dotti, MD, Barbara Savoldo, MD PhD, Helen E. Heslop, MDDSc, Malcolm K. Brenner, MD PhD

Blood (2018) 132 (Supplement 1): 680.

https://doi.org/10.1182/blood-2018-99-111202

Published: 2018

Journal Articles

Targeting Lymphomas Using Non-Engineered, Multi-Antigen Specific T Cells

George Carrum, MD, Premal Lulla, MBBS, Ifigeneia Tzannou, MD, Ayumi Watanabe, Manik Kuvalekar, Mrinalini Bilgi, Rammurti Kamble, MD, Carlos A. Ramos, MD, Rayne Rouce, MD, Bambi J. Grilley, RPh, Adrian P. Gee, PhD, Malcolm K. Brenner, MD PhD, Helen E. Heslop, MDDSc, Cliona M. Rooney, PhD, Juan F. Vera, MD, Ann M. Leen, PhD

Blood (2018) 132 (Supplement 1): 1685.

https://doi.org/10.1182/blood-2018-99-113140

Published: 2018

Journal Articles

Autologous EBV-Specific T Cells (CMD-003): Early Results from a Multicenter, Multinational Phase 2 Trial for Treatment of EBV-Associated NK/T-Cell Lymphoma

Blood (2017) 130 (Supplement 1): 4073.

https://doi.org/10.1182/blood.V130.Suppl_1.4073.4073

Published: 2017

Journal Articles

Adoptive Immunotherapy with Rapidly-Generated Multivirus-Specific T Cells Against AdV, EBV, CMV, HHV6 and BK after Allogeneic Hematopoietic Stem Cell Transplant

Blood (2017) 130 (Supplement 1): 4484.

https://doi.org/10.1182/blood.V130.Suppl_1.4484.4484

Published: 2017

Journal Articles

Phase 1 Clinical Trial of Adoptive Immunotherapy Using "Off-the-Shelf" Activated Natural Killer Cells (aNK) in Patients with Refractory/Relapsed Acute Myeloid Leukemia

Michael Boyiadzis, MD MHSc, Mounzer Agha, MD, Robert L Redner, MD, Alison Sehgal, MD, Annie Im, MD, Jing-Zhou Hou, Rafic Farah, MD, Kathleen A. Dorritie, MD, Anastasios Raptis, MD PhD, Seah H. Lim, MDPhDFRCP,FRCPath,MBBS, Hans Klingemann, MD PhD, Hong Wang, PhD, Natalia Lapteva, PhD, Mei Zhuyong, MD, Lisa H Butterfield, PhD, Cliona M. Rooney, PhD, Theresa L Whiteside, PhD

Blood (2016) 128 (22): 1649.

https://doi.org/10.1182/blood.V128.22.1649.1649

Published: 2016

Journal Articles

Administration of Most Closely HLA-Matched Multivirus-Specific T Cells for the Treatment of EBV, CMV, AdV, HHV6, and BKV Post Allogeneic Hematopoietic Stem Cell Transplant

Ifigeneia Tzannou, MD, Anastasia Papadopoulou, PhD, Ayumi Watanabe, Manik Kuvalekar, Adrian P. Gee, PhD, Swati Naik, MD, Caridad Martinez, MD, Kathryn S. Leung, Ghadir S. Sasa, MD, Robert A. Krance, MD, George Carrum, MD, Carlos A. Ramos, MD, Bambi Grilley, Malcolm K. Brenner, MD PhD, Cliona M. Rooney, PhD, Helen E Heslop, MD DSc (Hon), Ann M. Leen, PhD, Bilal Omer, MD

Blood (2016) 128 (22): 501.

https://doi.org/10.1182/blood.V128.22.501.501

Published: 2016

Journal Articles

CAR T Cells Targeted with a High Affinity Scfv Against the HCMV Glycoprotein Gb As Adoptive T Cell Therapy after Hematopoietic Stem Cell Transplantation

Renata Stripecke, PhD, Laura Gerasch, Sebastian Theobald, Bala Sai Sundarasetty, PhD, Maksim Mamonkin, PhD, Thomas Shum, BS, Cliona M. Rooney, PhD

Blood (2016) 128 (22): 5721.

https://doi.org/10.1182/blood.V128.22.5721.5721

Published: 2016

Journal Articles

Rapidly-Generated EBV-Specific T Cells (EBVST-cells) to Treat Type 2 Latency Lymphoma

Rayne H. Rouce, MD, Birju Mehta, Sandhya Sharma, Serena Kimi Perna, MD, Benjamin Shin, Vicky Torrano, Fnu Spoorthi, Natalia Lapteva, PhD, Catherine M. Bollard, MD, Adrian P. Gee, PhD, Carlos A. Ramos, MD, Shannon Inman, Karen L. Hodgkin, Kurt C. Gunter, MD, Malcolm K. Brenner, MD PhD, Helen E. Heslop, MD, Cliona M. Rooney, PhD

Blood (2016) 128 (22): 2990.

https://doi.org/10.1182/blood.V128.22.2990.2990

Published: 2016

Journal Articles

Fast and Efficient Gene Editing in Human Hematopoietic Cells

Michael C Gundry, BS, Lorenzo Brunetti, MD, Dimitrios Laurin Wagner, Joanne Hsu, BS, Mireya Paulina Velasquez, MD, Stephen Gottschalk, MD, Cliona M. Rooney, PhD, Margaret Goodell, PhD

Blood (2016) 128 (22): 4704.

https://doi.org/10.1182/blood.V128.22.4704.4704

Published: 2016

Journal Articles

Direct Comparison of In Vivo Fate of Second and Third-Generation CD19-Specific Chimeric Antigen Receptor (CAR)-T Cells in Patients with B-Cell Lymphoma: Reversal of Toxicity from Tonic Signaling

Diogo Gomes da Silva, Malini Mukherjee, Madhuwanti Srinivasan, Olga Dakhova, PhD, Hao Liu, PhD, Bambi Grilley, Adrian P. Gee, PhD, Sattva S. Neelapu, MD, Cliona M. Rooney, PhD, Helen E Heslop, MD DSc (Hon), Barbara Savoldo, MD PhD, Gianpietro Dotti, MD, Malcolm K. Brenner, MD PhD, Maksim Mamonkin, PhD, Carlos A. Ramos, MD

Blood (2016) 128 (22): 1851.

https://doi.org/10.1182/blood.V128.22.1851.1851

Published: 2016

Journal Articles

Safety of Multiple Doses of CAR T Cells

Rayne H. Rouce, MD, Kristen Fousek, Nabil Ahmed, MD, Stephen Gottschalk, MD, Barbara Savoldo, MD, Gianpietro Dotti, MD, Carlos A. Ramos, MD, Chrystal Louis, MD, Cliona M. Rooney, PhD, Malcolm K. Brenner, MD PhD, Helen E. Heslop, MD

Blood (2015) 126 (23): 4425.

https://doi.org/10.1182/blood.V126.23.4425.4425

Published: 2015

Journal Articles

Chimeric T Cells for Therapy of CD30+ Hodgkin and Non-Hodgkin Lymphomas

Carlos A. Ramos, MD, Brandon Ballard, BS, Enli Liu, MD MS, Olga Dakhova, PhD, Zhuyong Mei, MD, Hao Liu, PhD, Bambi Grilley, RPh, Cliona M. Rooney, PhD, Adrian P. Gee, PhD, Bill H. Chang, MD PhD, Catherine M. Bollard, MD, Malcolm K. Brenner, MD PhD, Gianpietro Dotti, MD, Helen E. Heslop, MD, Barbara Savoldo, MD PhD

Blood (2015) 126 (23): 185.

https://doi.org/10.1182/blood.V126.23.185.185

Published: 2015

Journal Articles

Administration of Most Closely HLA-Matched Multivirus-Specific T Cells for the Treatment of EBV, CMV, AdV, HHV6, and BKV Post Allogeneic Hematopoietic Stem Cell Transplant

Bilal Omer, MD, Anastasia Papadopoulou, PhD, Nikita Koottiyaniyil, Adrian P. Gee, PhD, Swati Naik, MD, Caridad Marinez, MD, Leung Kathryn, MD, Ghadir S. Sasa, MD, Robert A. Krance, MD, Bambi Grilley, RPh, Malcolm K. Brenner, MD PhD, Cliona M. Rooney, PhD, Helen E. Heslop, MD, Ann M. Leen, PhD, Ifigeneia Tzannou, MD

Blood (2015) 126 (23): 622.

https://doi.org/10.1182/blood.V126.23.622.622

Published: 2015

Journal Articles

Immunotherapy for Lymphoma Using T Cells Targeting Multiple Tumor Associated Antigens

Ann Leen, PhD, Ifigeneia Tzannou, MD, Munu Bilgi, Hao Liu, PhD, Juan F Vera, MD, Ulrike Gerdemann, MD, Rammurti T Kamble, MD, Carlos A. Ramos, MD, Bambi Grilley, RPh, Adrian P. Gee, PhD, Catherine M. Bollard, MD, Malcolm K. Brenner, MD PhD, Helen E. Heslop, MD, Cliona M. Rooney, PhD, George Carrum, MD

Blood (2015) 126 (23): 186.

https://doi.org/10.1182/blood.V126.23.186.186

Published: 2015

Journal Articles

Adoptively-Transferred EBV-Specific T Cells to Prevent or Treat EBV-Related Lymphoproliferative Disease in Allogeneic HSCT Recipients - a Single Center Experience Spanning 22 Years

Ifigeneia Tzannou, MD, Bilal Omer, MD, Anastasia Papadopoulou, PhD, Ulrike Gerdemann, MD, Colton Smith, PhD, Adrian P. Gee, PhD, Bambi J Grilley, Malcolm K. Brenner, MB, PhD FRCP, FRCPath, Catherine M. Bollard, MD, Ann M. Leen, PhD, Cliona M. Rooney, PhD, Helen E. Heslop, MD

Blood (2015) 126 (23): 1926.

https://doi.org/10.1182/blood.V126.23.1926.1926

Published: 2015

Journal Articles

T Cells Expressing CD19-Specific Chimeric Antigen Receptors Are Inhibited By Indoleamine 2,3-Dioxygenase in Tumors

Soranobu Ninomiya, MD PhD, Leslie E Huye, PhD, Barbara Savoldo, MD PhD, Gianpietro Dotti, MD, Helen E. Heslop, MD, Malcolm K. Brenner, MD PhD, Cliona M Rooney, PhD, Carlos A. Ramos, MD

Blood (2014) 124 (21): 2434.

https://doi.org/10.1182/blood.V124.21.2434.2434

Published: 2014

Journal Articles

Graft Versus Leukemia Response without Graft Versus Host Disease Elicited By Adoptively Transferred Multivirus-Specific T-Cells

Paul A. Castillo, MD, Jan J Melenhorst, PhD, Patrick J Hanley, PhD, Michael Keller, MD, Robert A. Krance, MD, Judith Margolin, MD, Ann Leen, PhD, Helen E. Heslop, MD, John Barrett, MD, Cliona M Rooney, PhD, Catherine M. Bollard, MD FRACP, FRCPA

Blood (2014) 124 (21): 2439.

https://doi.org/10.1182/blood.V124.21.2439.2439

Published: 2014

Journal Articles

Ex Vivo Expanded Multi-Specific Cytotoxic T Lymphocytes Derived From HIV+ Patients and HIV Negative Donors Using GMP Compliant Methodologies Recognize Multiple HIV Antigens and Suppress HIV Replication

Sharon Lam, BS, Julia Marsh Sung, MD, Conrad RY Cruz, MD, PhD, Paul Castillo-Caro, MD, Minh T. Ngo, PhD, Carolina Garrido, PhD, Joann Kuruc, MSN, RN, Cliona M. Rooney, PhD, David Margolis, MD, Catherine M. Bollard, MBChB, MD

Blood (2013) 122 (21): 188.

https://doi.org/10.1182/blood.V122.21.188.188

Published: 2013

NARROW

A Bank of CD30.CAR-Modified, Epstein-Barr Virus-Specific T Cells That Lacks Host Reactivity and Resists Graft Rejection for Patients with CD30-Positive Lymphoma

CD70-Specific CAR T Cells Have Potent Activity Against Acute Myeloid Leukemia (AML) without HSC Toxicity

CD30-Chimeric Antigen Receptor (CAR) T Cells for Therapy of Hodgkin Lymphoma (HL)

Targeting Lymphomas Using Non-Engineered, Multi-Antigen Specific T Cells

Autologous EBV-Specific T Cells (CMD-003): Early Results from a Multicenter, Multinational Phase 2 Trial for Treatment of EBV-Associated NK/T-Cell Lymphoma

Adoptive Immunotherapy with Rapidly-Generated Multivirus-Specific T Cells Against AdV, EBV, CMV, HHV6 and BK after Allogeneic Hematopoietic Stem Cell Transplant

Phase 1 Clinical Trial of Adoptive Immunotherapy Using "Off-the-Shelf" Activated Natural Killer Cells (aNK) in Patients with Refractory/Relapsed Acute Myeloid Leukemia

Administration of Most Closely HLA-Matched Multivirus-Specific T Cells for the Treatment of EBV, CMV, AdV, HHV6, and BKV Post Allogeneic Hematopoietic Stem Cell Transplant

CAR T Cells Targeted with a High Affinity Scfv Against the HCMV Glycoprotein Gb As Adoptive T Cell Therapy after Hematopoietic Stem Cell Transplantation

Rapidly-Generated EBV-Specific T Cells (EBVST-cells) to Treat Type 2 Latency Lymphoma

Fast and Efficient Gene Editing in Human Hematopoietic Cells

Direct Comparison of In Vivo Fate of Second and Third-Generation CD19-Specific Chimeric Antigen Receptor (CAR)-T Cells in Patients with B-Cell Lymphoma: Reversal of Toxicity from Tonic Signaling

Safety of Multiple Doses of CAR T Cells

Chimeric T Cells for Therapy of CD30+ Hodgkin and Non-Hodgkin Lymphomas

Administration of Most Closely HLA-Matched Multivirus-Specific T Cells for the Treatment of EBV, CMV, AdV, HHV6, and BKV Post Allogeneic Hematopoietic Stem Cell Transplant

Immunotherapy for Lymphoma Using T Cells Targeting Multiple Tumor Associated Antigens

Adoptively-Transferred EBV-Specific T Cells to Prevent or Treat EBV-Related Lymphoproliferative Disease in Allogeneic HSCT Recipients - a Single Center Experience Spanning 22 Years

T Cells Expressing CD19-Specific Chimeric Antigen Receptors Are Inhibited By Indoleamine 2,3-Dioxygenase in Tumors

Graft Versus Leukemia Response without Graft Versus Host Disease Elicited By Adoptively Transferred Multivirus-Specific T-Cells

Ex Vivo Expanded Multi-Specific Cytotoxic T Lymphocytes Derived From HIV+ Patients and HIV Negative Donors Using GMP Compliant Methodologies Recognize Multiple HIV Antigens and Suppress HIV Replication

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American Society of Hematology

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American Society of Hematology

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