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Journal Articles

Perforin Is Dispensable for Anti-CD19 CAR-T Cell Cytotoxicity but Contributes to CAR-T Cell Contraction and Regulates Host Inflammatory Response

Kazusa Ishii, MDMPH, Christopher Daniel Chien, PhD, Rebecca Erwin-Cohen, PhD, Howard A Young, PhD, Terry J. Fry, MD

Blood (2017) 130 (Supplement 1): 1918.

https://doi.org/10.1182/blood.V130.Suppl_1.1918.1918

Published: 2017

Journal Articles

Direct Comparison of Anti-CD33 and Anti-CD123 Chimeric Antigen Receptor T Cells with CD28 or 41BB Co-Stimulatory Domains for Treatment of Acute Myeloid Leukemia

Samiksha Tarun, MSc, Haiying Qin, MS, Lila Yang, BS, Christopher Daniel Chien, PhD, Mark Eric Kohler, MD PhD, Terry J. Fry, MD

Blood (2017) 130 (Supplement 1): 1370.

https://doi.org/10.1182/blood.V130.Suppl_1.1370.1370

Published: 2017

Journal Articles

Evaluating on-Target Toxicity of Hematopoietic-Targeting Cars Demonstrates Target-Nonspecific Suppression of Marrow Progenitors

Christopher Tor Sauter, BA, Christopher Daniel Chien, PhD, Feng Shen, MD PhD, Sarah K Tasian, MD, Terry J Fry, MD

Blood (2016) 128 (22): 3357.

https://doi.org/10.1182/blood.V128.22.3357.3357

Published: 2016

Journal Articles

Preclinical Development of FLT3-Redirected Chimeric Antigen Receptor T Cell Immunotherapy for Acute Myeloid Leukemia

Christopher Daniel Chien, PhD, Christopher Tor Sauter, BA, Kazusa Ishii, MD MPH, Sang Minh Nguyen, BS, Feng Shen, MD PhD, Sarah K Tasian, MD, Weizao Chen, PhD, Dimiter S Dimitrov, PhD, Terry J Fry, MD

Blood (2016) 128 (22): 1072.

https://doi.org/10.1182/blood.V128.22.1072.1072

Published: 2016

Journal Articles

CRLF2 /Tslpr Overexpressing Acute Lymphoblastic Leukemia Relapse Is Driven By Chemotherapy-Induced TSLP from Bone Marrow Stromal Cells

Christopher Daniel Chien, PhD, Sang Minh Nguyen, BS, Haiying Qin, MS, Elad Jacoby, MD, Terry J. Fry, MD

Blood (2015) 126 (23): 1432.

https://doi.org/10.1182/blood.V126.23.1432.1432

Published: 2015

Journal Articles

CD4 CAR T Cells Mediate CD8-like Cytotoxic Anti-Leukemic Effects Resulting in Leukemic Clearance and Are Less Susceptible to Attenuation By Endogenous TCR Activation Than CD8 CAR T Cells

Yinmeng Yang, BS, Tasha Lin, MD, Elad Jacoby, MD, Haiying Qin, MS, Elizabeth Grier Gardner, MD, Christopher Daniel Chien, PhD, Daniel W. Lee, III, MD, Terry J. Fry, MD

Blood (2015) 126 (23): 100.

https://doi.org/10.1182/blood.V126.23.100.100

Published: 2015

Journal Articles

Lineage Switch As a Relapse Mechanism of Pre-B Acute Lymphoblastic Leukemia Following CD19 CAR

Elad Jacoby, MD, Sang Minh Nguyen, BS, Kathryn M Welp, Haiying Qin, MS, Yinmeng Yang, BS, Christopher Daniel Chien, PhD, John Shern, MD, Terry J. Fry, MD

Blood (2015) 126 (23): 2524.

https://doi.org/10.1182/blood.V126.23.2524.2524

Published: 2015

Journal Articles

CD19 CAR T Cells Maintain Efficacy in the Allogeneic Environment but Mediate Acute Graft-Versus-Host-Disease Only in the Presence CD19+ Acute Lymphoblastic Leukemia

Elad Jacoby, MD, Haiying Qin, MS, Yinmeng Yang, BS, Christopher Daniel Chien, PhD, Terry J Fry, MD

Blood (2014) 124 (21): 1115.

https://doi.org/10.1182/blood.V124.21.1115.1115

Published: 2014

Journal Articles

41BBL-Based Activation and Expansion of Autologous Natural Killer Cells Results in Enhanced Activity Against Leukemia Including ALL

Ekta Kapadia, MD, Elad Jacoby, MD, Mark Kohler, MDPhD, Waleed Haso, M.S., Christopher Daniel Chien, PhD, Terry J Fry, MD

Blood (2014) 124 (21): 2293.

https://doi.org/10.1182/blood.V124.21.2293.2293

Published: 2014

Journal Articles

Presence of Endogenous TCR Antigen in Vivo Attenuates Efficacy of Anti-CD19 Targeted CAR T Cell Therapy

Yinmeng Yang, BS, Christopher Daniel Chien, PhD, Elad Jacoby, MD, Haiying Qin, MS, Waleed Haso, MS, Terry J Fry, MD

Blood (2014) 124 (21): 3721.

https://doi.org/10.1182/blood.V124.21.3721.3721

Published: 2014

NARROW

Perforin Is Dispensable for Anti-CD19 CAR-T Cell Cytotoxicity but Contributes to CAR-T Cell Contraction and Regulates Host Inflammatory Response

Direct Comparison of Anti-CD33 and Anti-CD123 Chimeric Antigen Receptor T Cells with CD28 or 41BB Co-Stimulatory Domains for Treatment of Acute Myeloid Leukemia

Evaluating on-Target Toxicity of Hematopoietic-Targeting Cars Demonstrates Target-Nonspecific Suppression of Marrow Progenitors

Preclinical Development of FLT3-Redirected Chimeric Antigen Receptor T Cell Immunotherapy for Acute Myeloid Leukemia

CRLF2 /Tslpr Overexpressing Acute Lymphoblastic Leukemia Relapse Is Driven By Chemotherapy-Induced TSLP from Bone Marrow Stromal Cells

CD4 CAR T Cells Mediate CD8-like Cytotoxic Anti-Leukemic Effects Resulting in Leukemic Clearance and Are Less Susceptible to Attenuation By Endogenous TCR Activation Than CD8 CAR T Cells

Lineage Switch As a Relapse Mechanism of Pre-B Acute Lymphoblastic Leukemia Following CD19 CAR

CD19 CAR T Cells Maintain Efficacy in the Allogeneic Environment but Mediate Acute Graft-Versus-Host-Disease Only in the Presence CD19+ Acute Lymphoblastic Leukemia

41BBL-Based Activation and Expansion of Autologous Natural Killer Cells Results in Enhanced Activity Against Leukemia Including ALL

Presence of Endogenous TCR Antigen in Vivo Attenuates Efficacy of Anti-CD19 Targeted CAR T Cell Therapy

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American Society of Hematology

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ASH Publications

American Society of Hematology

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