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Journal Articles

Delivery of Fviii-mcoET3 to Previously Untreated Sheep Using Human Placental Cells Enables Durable Elevation of Plasma FVIII Levels and Avoids Inhibitor Formation

Brady Trevisan, Martin Rodriguez, BSc, Sunil George, PhD, Shannon Lankford, Jordan E Shields, MS, Jorge Figueroa, MD, Diane Meares, John Owen, MDMBA,FRCPC, Anthony Atala, MD, Christopher B Doering, PhD, H. Trent Spencer, PhD, Christopher D Porada, PhD, M. Graca Almeida-Porada, MD PhD

Blood (2020) 136 (Supplement 1): 34.

https://doi.org/10.1182/blood-2020-140745

Published: 2020

Journal Articles

Evaluation of Maternal Safety Following Prenatal Cell and Gene Therapy for Hemophilia a in a Large Animal Model Demonstrates Absence of Maternal Exposure to the Cells or Gene Products Infused into the Fetus

Quan DM Pham, Martin Rodriguez, BSc, Ritu M Ramamurthy, Sunil George, PhD, Jorge Figueroa, MD, Anthony Atala, MD, Christopher B Doering, PhD, H. Trent Spencer, PhD, Christopher D Porada, PhD, M. Graca Almeida-Porada, MD PhD

Blood (2020) 136 (Supplement 1): 32.

https://doi.org/10.1182/blood-2020-140883

Published: 2020

Journal Articles

Administration of Cells Engineered to Secrete Fviii-mcoET3 in Prenatal Sheep Recipients Results in Sustained Curative Fviii Plasma Levels for 3 Years after Birth, without Immune or Toxicity-Related Adverse Events

Martin Rodriguez, BSc, Brady Trevisan, Sunil George, PhD, Ritu M Ramamurthy, Andrew Rabah, Jordan E Shields, MS, Denise Schwahn, DVM, Jorge Figueroa, MD, Diane Meares, John Owen, MDMBA,FRCPC, Michael Gautreaux, PhD, D.ABHI, Anthony Atala, MD, Christopher B Doering, PhD, H. Trent Spencer, PhD, Christopher D Porada, PhD, M. Graca Almeida-Porada, MD PhD

Blood (2020) 136 (Supplement 1): 1–2.

https://doi.org/10.1182/blood-2020-140845

Published: 2020

Journal Articles

Recreating the Hematopoietic Microenvironment in Vitro Using Microfluidic “on-a-Chip” Technology Enables the Study of Interactions of Normal and Malignant HSPC with Specific Bone Marrow Niches

Sunil George, PhD, Julio Aleman, MS, M. Graca Almeida-Porada, MD PhD, Aleksander Skardal, PhD, Christopher D Porada, PhD

Blood (2017) 130 (Supplement 1): 3779.

https://doi.org/10.1182/blood.V130.Suppl_1.3779.3779

Published: 2017

Journal Articles

Prenatal Transplantation of Placental Cells Engineered to Express FVIII Leads to Corrective Plasma Levels of FVIII after Birth

M. Graca Almeida-Porada, MD PhD, Sunil George, PhD, Alshaima Morsi, MD, Nadia El-Akabawy, MD, Jorge Figueroa, Jordan E Shields, MS, Diane Meares, Andrew M. Farland, MD, Anthony Atala, MD, Christopher B Doering, PhD, H. Trent Spencer, PhD, Christopher D Porada, PhD

Blood (2017) 130 (Supplement 1): 361.

https://doi.org/10.1182/blood.V130.Suppl_1.361.361

Published: 2017

Journal Articles

A New Approach to Expand Cord Blood Derived Hematopoietic Stem Cells, Using Bioengineered Human Fetal Liver Tissue 3D-Constructs

Saloomeh Mokhtari, Pedro Baptista, Dipen Vyas, PhD, Charles Jordan Freeman, Emma Moran, PhD, Christopher D Porada, PhD, Shay Soker, PhD, Graca Almeida-Porada, MD PhD

Blood (2015) 126 (23): 3097.

https://doi.org/10.1182/blood.V126.23.3097.3097

Published: 2015

Journal Articles

A Human Bone Marrow-Derived Stromal Cell Population with Hemogenic Potential

Saloomeh Mokhtari, Evan Joseph Colletti, PhD, Chad Sanada, PhD, Zanetta S. Lamar, MD, Paul J Simmons, Anthony Atala, MD, Diane S Krause, MD PhD, Esmail D. Zanjani, PhD, Christopher D Porada, PhD, Graca Almeida-Porada, MD PhD

Blood (2015) 126 (23): 1201.

https://doi.org/10.1182/blood.V126.23.1201.1201

Published: 2015

Journal Articles

Defining Engraftment Patterns and Interactions Between Hematopoietic Stem Cells and Stromal Cells after in Utero Transplantation

Saloomeh Mokhtari, Christopher D Porada, PhD, Evan Joseph Colletti, PhD, Graca Almeida-Porada, MD PhD

Blood (2015) 126 (23): 1869.

https://doi.org/10.1182/blood.V126.23.1869.1869

Published: 2015

Journal Articles

CD166+CD34+ Cells Exhibit Marked Functional Differences During Fetal and Adult Life

Saloomeh Mokhtari, Zanetta S. Lamar, MD, Chris Booth, Frank Marini, III, PhD, Christopher D Porada, PhD, Graca Almeida-Porada, MD, PhD

Blood (2013) 122 (21): 2435.

https://doi.org/10.1182/blood.V122.21.2435.2435

Published: 2013

Journal Articles

RUNX1C-Mediated Reprogramming Of Human Bone Marrow Stromal Cells into Early Blood Progenitors

Weihong Yin, PhD, Christopher D Porada, PhD, Stephen Walker, PhD, Colin Bishop, PhD, Graca Almeida-Porada, MD, PhD

Blood (2013) 122 (21): 2463.

https://doi.org/10.1182/blood.V122.21.2463.2463

Published: 2013

Journal Articles

Optimization Of Vascular Niches To Increase Hematopoietic Engraftment

Saloomeh Mokhtari, Evan Colletti, PhD, Christopher D Porada, PhD, Graca Almeida-Porada, MD, PhD

Blood (2013) 122 (21): 4456.

https://doi.org/10.1182/blood.V122.21.4456.4456

Published: 2013

Journal Articles

Niche Perivascular Stromal Cells As a Potential Reservoir and a Source of HCMV Reactivation

Melisa Soland, PhD, Lisa Keyes, PhD, Christopher D Porada, PhD, Stephen St. Jeor, PhD, Graca Almeida-Porada, MD, PhD

Blood (2012) 120 (21): 3464.

https://doi.org/10.1182/blood.V120.21.3464.3464

Published: 2012

Journal Articles

Mesenchymal Stem Cells Engineered to Inhibit Complement-Mediated Damage

Melisa Soland, PhD, Mariana Bego, PhD, Evan Colletti, PhD, Christopher D Porada, PhD, Esmail Zanjani, PhD, Stephen St. Jeor, PhD, Graca Almeida-Porada, MD, PhD

Blood (2012) 120 (21): 1253.

https://doi.org/10.1182/blood.V120.21.1253.1253

Published: 2012

Journal Articles

Origin and Characterization of CD166+ Cells During Human Marrow Ontogeny

Saloomeh Mokhtari, BS, Evan Colletti, PhD, Christopher D Porada, PhD, Graca Almeida-Porada, MD, PhD

Blood (2012) 120 (21): 1252.

https://doi.org/10.1182/blood.V120.21.1252.1252

Published: 2012

Journal Articles

Identification and Phenotypic Characterization of a Subpopulation of Acute Myelogenous Leukemia (AML) Cells with Increased Plastic Adherence.

Katharine Greenfield, BS, Saloomeh Mokhtari, BS, Melissa Haug, Christopher D Porada, PhD, Graca Almeida-Porada, MD, PhD

Blood (2012) 120 (21): 2556.

https://doi.org/10.1182/blood.V120.21.2556.2556

Published: 2012

Journal Articles

Development and Characterization of Recombinant Ovine Factor VIII

Philip M Zakas, Bagirath Gangadharan, MS, Graca Almeida-Porada, MD, PhD, Christopher D Porada, PhD, H. Trent Spencer, PhD, Christopher B Doering, PhD

Blood (2011) 118 (21): 1193.

https://doi.org/10.1182/blood.V118.21.1193.1193

Published: 2011

Journal Articles

Timing of Mesenchymal Stem Cell Co-Transplantation and Site of Bone Engraftment Determine Levels of Hematopoietic Engraftment and Contribution of HSC to the Bone Niche

Evan Colletti, Saloomeh Mokhtari, Chad Sanada, Esmail D Zanjani, Christopher D Porada, PhD, Graca Almeida-Porada, MD, PhD

Blood (2010) 116 (21): 940.

https://doi.org/10.1182/blood.V116.21.940.940

Published: 2010

Journal Articles

Modulation of Mesenchymal Stem Cell MHC-I Complex Increases Engraftment In Vivo.

Melisa Soland, Evan J Colletti, Mariana Bego, Chad Sanada, Christopher D Porada, PhD, Esmail D Zanjani, Stephen St. Jeor, Graca Almeida-Porada, MD, PhD

Blood (2010) 116 (21): 1457.

https://doi.org/10.1182/blood.V116.21.1457.1457

Published: 2010

Journal Articles

Successful In Utero Hematopoietic Stem Cell Transplantation (IUHSCT) Likely Depends on Niche Maturity, Recipient/Donor MHC Compatibility and Donor Cell Origin

Christine Jeanblanc, Evan J Colletti, Christopher D Porada, PhD, Graca Almeida-Porada, MD, PhD, Esmail Zanjani

Blood (2010) 116 (21): 574.

https://doi.org/10.1182/blood.V116.21.574.574

Published: 2010

Journal Articles

Naturally-Occurring Antibodies to Human AAV In Sheep: A New Large Animal Model for Immune Aspects of AAV Gene Transfer.

Joseph Tellez, Jonathan D. Finn, PhD, Nicholas Tschernia, Graca Almeida-Porada, MD, PhD, Valder Arruda, MD, PhD, Christopher D Porada, PhD

Blood (2010) 116 (21): 3762.

https://doi.org/10.1182/blood.V116.21.3762.3762

Published: 2010

NARROW

Delivery of Fviii-mcoET3 to Previously Untreated Sheep Using Human Placental Cells Enables Durable Elevation of Plasma FVIII Levels and Avoids Inhibitor Formation

Evaluation of Maternal Safety Following Prenatal Cell and Gene Therapy for Hemophilia a in a Large Animal Model Demonstrates Absence of Maternal Exposure to the Cells or Gene Products Infused into the Fetus

Administration of Cells Engineered to Secrete Fviii-mcoET3 in Prenatal Sheep Recipients Results in Sustained Curative Fviii Plasma Levels for 3 Years after Birth, without Immune or Toxicity-Related Adverse Events

Recreating the Hematopoietic Microenvironment in Vitro Using Microfluidic “on-a-Chip” Technology Enables the Study of Interactions of Normal and Malignant HSPC with Specific Bone Marrow Niches

Prenatal Transplantation of Placental Cells Engineered to Express FVIII Leads to Corrective Plasma Levels of FVIII after Birth

A New Approach to Expand Cord Blood Derived Hematopoietic Stem Cells, Using Bioengineered Human Fetal Liver Tissue 3D-Constructs

A Human Bone Marrow-Derived Stromal Cell Population with Hemogenic Potential

Defining Engraftment Patterns and Interactions Between Hematopoietic Stem Cells and Stromal Cells after in Utero Transplantation

CD166+CD34+ Cells Exhibit Marked Functional Differences During Fetal and Adult Life

RUNX1C-Mediated Reprogramming Of Human Bone Marrow Stromal Cells into Early Blood Progenitors

Optimization Of Vascular Niches To Increase Hematopoietic Engraftment

Niche Perivascular Stromal Cells As a Potential Reservoir and a Source of HCMV Reactivation

Mesenchymal Stem Cells Engineered to Inhibit Complement-Mediated Damage

Origin and Characterization of CD166+ Cells During Human Marrow Ontogeny

Identification and Phenotypic Characterization of a Subpopulation of Acute Myelogenous Leukemia (AML) Cells with Increased Plastic Adherence.

Development and Characterization of Recombinant Ovine Factor VIII

Timing of Mesenchymal Stem Cell Co-Transplantation and Site of Bone Engraftment Determine Levels of Hematopoietic Engraftment and Contribution of HSC to the Bone Niche

Modulation of Mesenchymal Stem Cell MHC-I Complex Increases Engraftment In Vivo.

Successful In Utero Hematopoietic Stem Cell Transplantation (IUHSCT) Likely Depends on Niche Maturity, Recipient/Donor MHC Compatibility and Donor Cell Origin

Naturally-Occurring Antibodies to Human AAV In Sheep: A New Large Animal Model for Immune Aspects of AAV Gene Transfer.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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