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Journal Articles

Targeting CD38 Suppresses Induction and Function of T Regulatory Cells to Reverse Immunosuppression in Multiple Myeloma

Xiaoyan Feng, Chirag Acharya, MD, Gang An, MD PhD, Kenneth Wen, Li Zhang, Alireza Kalbasi, Lugui Qiu, MD, Nikhil C Munshi, MD, Yu-Tzu Tai, PhD, Kenneth C. Anderson, MD

Blood (2016) 128 (22): 2106.

https://doi.org/10.1182/blood.V128.22.2106.2106

Published: 2016

Journal Articles

APRIL/B Cell Maturation Antigen (BCMA) Signaling Cascades Promote Human Multiple Myeloma Growth and Mediate Immunosuppression in the Bone Marrow Microenvironment Via IL-10, TGF-b, and PD-L1

Yu-Tzu Tai, PhD, Chirag Acharya, MD, Gang An, MDPhD, Michele Moschetta, MD, Mike Zhong, BS, Xiaoyan Feng, MD, Hans van Eenennaam, PhD, Andrea van Elsas, PhD, Lugui Qiu, MD PhD, Nikhil C. Munshi, MD, Kenneth C Anderson, MD

Blood (2015) 126 (23): 1810.

https://doi.org/10.1182/blood.V126.23.1810.1810

Published: 2015

Journal Articles

Activation of Lysosomal Function and Reactive Oxygen Species Play Crucial Roles in SAR650984-Induced Direct Killing of Human Multiple Myeloma Cells with Mutated p53, Which Is Further Augmented By Pomalidomide

Hua Jiang, MDPhD, Chirag Acharya, MD, Gang An Gang An, MDPhD, Xiaoyan Feng, MD, Zhili Song, Guang Yang, PhD, Francisco Adrian, Lugui Qiu, MD, Paul Richardson, MD, Nikhil C. Munshi, MD, Yu-Tzu Tai, PhD, Kenneth C Anderson, MD

Blood (2015) 126 (23): 4253.

https://doi.org/10.1182/blood.V126.23.4253.4253

Published: 2015

Journal Articles

A Novel Anti-a Proliferation-Inducing Ligand Hapril.01A Monoclonal Antibody Targets Multiple Myeloma Cells in the Bone Marrow Microenvironment

Yu-Tzu Tai, PhD, Chirag Acharya, MD, Gang An, MD PhD, Mike Y Zhong, Michele Cea, MD, Antonia Cagnetta, MD, Hua Jiang, MDPhD, Hans van Eenennaam, PhD, Andrea van Elsas, PhD, Nikhil C. Munshi, MD, Kenneth C. Anderson

Blood (2014) 124 (21): 2098.

https://doi.org/10.1182/blood.V124.21.2098.2098

Published: 2014

Journal Articles

SAR 650984, a Therapeutic Anti-CD38 Monoclonal Antibody, Blocks CD38-CD31 Interaction in Multiple Myeloma

Gang An, MD PhD, Hua Jiang, MDPhD, Chirag Acharya, MD, Mike Y Zhong, BS, Ti Cai, PhD, Guang Yang, Zhili Song, Joachim Theilhaber, PhD, Francisco Adrian, PhD, Yu-Tzu Tai, PhD, Kenneth C. Anderson, MD

Blood (2014) 124 (21): 4729.

https://doi.org/10.1182/blood.V124.21.4729.4729

Published: 2014

Journal Articles

NFκB Signaling and Mcl-1 Are Critical in B Cell Maturation Antigen-Promoted Multiple Myeloma Cell Growth and Survival

Chirag Acharya, MD, Gang An, MD PhD, Mike Y Zhong, Michele Cea, MD, Antonia Cagnetta, MD, Hua Jiang, MDPhD, Yu-Tzu Tai, PhD, Kenneth C. Anderson, MD

Blood (2014) 124 (21): 3384.

https://doi.org/10.1182/blood.V124.21.3384.3384

Published: 2014

Journal Articles

SAR650984 (SAR) Directly Promotes Homotypic Adhesion-Related Multiple Myeloma (MM) Cell Death and SAR-Induced Anti-MM Activities Are Enhanced By Pomalidomide, More Potently Than Lenalidomide

Hua Jiang, MDPhD, Gang An, MD PhD, Chirag Acharya, MD, Mike Y Zhong, BS, Ti Cai, PhD, Zhili Song, Guang Yang, Francisco Adrian, PhD, Nikhil C. Munshi, MD, Yu-Tzu Tai, PhD, Kenneth C. Anderson

Blood (2014) 124 (21): 2124.

https://doi.org/10.1182/blood.V124.21.2124.2124

Published: 2014

Journal Articles

Constitutive B-Cell Maturation Antigen (BCMA) Activation In Human Multiple Myeloma Cells Promotes Myeloma Cell Growth and Survival In The Bone Marrow Microenvironment Via Upregulated MCL-1 and NFκB Signaling

Yu-Tzu Tai, PhD, Chirag Acharya, MD, Mike Y Zhong, Michele Cea, MD, Antonia Cagnetta, MD, Paul G. Richardson, MD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD

Blood (2013) 122 (21): 681.

https://doi.org/10.1182/blood.V122.21.681.681

Published: 2013

Journal Articles

Intracellular NAD + Depletion Enhances Bortezomib-Induced Myeloma Cytotoxicity

Antonia Cagnetta, MD, Michele Cea, MD, Chirag Acharya, MD, Teresa Calimeri, MD, Yu-Tzu Tai, PhD, Teru Hideshima, MD, PhD, Dharminder Chauhan, PhD, Franco Patrone, Marco Gobbi, MD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD

Blood (2012) 120 (21): 330.

https://doi.org/10.1182/blood.V120.21.330.330

Published: 2012

Journal Articles

CRM1 Inhibition Abrogates Osteoclast Formation and Bone Resorption Via Inhibition of RANKL-Induced NFκB While Sparing Osteoblastogenesis: Further Therapeutic Implication in Multiple Myeloma

Chirag Acharya, MD, Mike Y Zhong, B.S., Yolanda Calle, PhD, Stephen Schey, MD, Michelle Chen, Daniel Tannenbaum, B.S., Michaela R Reagan, PhD, Irene M. Ghobrial, MD, Yosef Landesman, PhD, Sharon Shacham, PhD MBA, Michael Kauffman, MD, PhD, Kenneth C. Anderson, MD, Yu-Tzu Tai, PhD

Blood (2012) 120 (21): 1835.

https://doi.org/10.1182/blood.V120.21.1835.1835

Published: 2012

Journal Articles

Blockade of Nuclear Export Protein CRM1 (chromosomal region maintenance 1, XPO1) by a Novel, Potent and Selective CRM1 Inhibitor KPT-185 Induces Significant Antitumor Activity Against Human Multiple Myeloma

Sun-Young Kong, MD, PhD, Yosef Landesman, PhD, Jana Jakubikova, PhD, Michael A. Sellitto, Antonia Cagnetta, MD, Michele Cea, MD, Michelle C. Chen, Francesca Cottini, MD, Douglas W. McMillin, PhD, Chirag Acharya, MD, William Senapedis, PhD, Sharon Shacham, PhD, MBA, Michael Kauffman, MD, PhD, Dilara McCauley, PhD, Jean-Richard Saint-Martin, BS, Nikhil C. Munshi, MD, Paul G. Richardson, MD, Kenneth C. Anderson, MD, Yu-Tzu Tai, PhD

Blood (2011) 118 (21): 2913.

https://doi.org/10.1182/blood.V118.21.2913.2913

Published: 2011

NARROW

Targeting CD38 Suppresses Induction and Function of T Regulatory Cells to Reverse Immunosuppression in Multiple Myeloma

APRIL/B Cell Maturation Antigen (BCMA) Signaling Cascades Promote Human Multiple Myeloma Growth and Mediate Immunosuppression in the Bone Marrow Microenvironment Via IL-10, TGF-b, and PD-L1

Activation of Lysosomal Function and Reactive Oxygen Species Play Crucial Roles in SAR650984-Induced Direct Killing of Human Multiple Myeloma Cells with Mutated p53, Which Is Further Augmented By Pomalidomide

A Novel Anti-a Proliferation-Inducing Ligand Hapril.01A Monoclonal Antibody Targets Multiple Myeloma Cells in the Bone Marrow Microenvironment

SAR 650984, a Therapeutic Anti-CD38 Monoclonal Antibody, Blocks CD38-CD31 Interaction in Multiple Myeloma

NFκB Signaling and Mcl-1 Are Critical in B Cell Maturation Antigen-Promoted Multiple Myeloma Cell Growth and Survival

SAR650984 (SAR) Directly Promotes Homotypic Adhesion-Related Multiple Myeloma (MM) Cell Death and SAR-Induced Anti-MM Activities Are Enhanced By Pomalidomide, More Potently Than Lenalidomide

Constitutive B-Cell Maturation Antigen (BCMA) Activation In Human Multiple Myeloma Cells Promotes Myeloma Cell Growth and Survival In The Bone Marrow Microenvironment Via Upregulated MCL-1 and NFκB Signaling

Intracellular NAD + Depletion Enhances Bortezomib-Induced Myeloma Cytotoxicity

CRM1 Inhibition Abrogates Osteoclast Formation and Bone Resorption Via Inhibition of RANKL-Induced NFκB While Sparing Osteoblastogenesis: Further Therapeutic Implication in Multiple Myeloma

Blockade of Nuclear Export Protein CRM1 (chromosomal region maintenance 1, XPO1) by a Novel, Potent and Selective CRM1 Inhibitor KPT-185 Induces Significant Antitumor Activity Against Human Multiple Myeloma

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American Society of Hematology

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ASH Publications

American Society of Hematology

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