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Journal Articles

Selinexor in Combination with Chemotherapy or Idelalisib Elicits a Synergistic Cytotoxic Effect in Primary CLL Cells, Also Overcoming Intrinsic and Stromal Cells-Mediated Fludarabine Resistance

Maria Todaro, PhD, Valentina Griggio, Ms, Candida Vitale, MD, Chiara Salvetti, MD, Chiara Riganti, MD, Mario Boccadoro, MD, Yosef Landesman, PhD, Marta Coscia, MD PhD

Blood (2016) 128 (22): 3210.

https://doi.org/10.1182/blood.V128.22.3210.3210

Published: 2016

Journal Articles

ATP-Binding-Cassette A1 Regulates Extracellular Isopentenyl Pyrophosphate Release and Vγ9Vδ2 T-Cell Activation By Dendritic Cells

Patrizia Sciancalepore, MD, Barbara Castella, PhD, Chiara Riganti, MD, Myriam Foglietta, MD, Joanna Kopecka, PhD, Francesco Novelli, Giorgia Mandili, Ezio Tripoli, PharmD, Nico Mitro, Donatella Caruso, Mario Boccadoro, MD, Massimo Massaia, MD

Blood (2016) 128 (22): 3709.

https://doi.org/10.1182/blood.V128.22.3709.3709

Published: 2016

Journal Articles

HIF-1α Upregulation in TP53 Disrupted Chronic Lymphocytic Leukemia Cells and Its Potential Role As a Therapeutic Target

Blood (2016) 128 (22): 305.

https://doi.org/10.1182/blood.V128.22.305.305

Published: 2016

Journal Articles

The Hypoxia-Inducible Factor-1alpha Is Constitutively Upregulated in TP53 Disrupted CLL Cells: A Potential Target to Overcome Fludarabine Resistance

Valentina Griggio, Ms, Candida Vitale, MD, Chiara Riganti, MD, Joanna Kopecka, PhD, Michele Dal Bo, Davide Rossi, MD PhD, Gabriele Pozzato, MD, Luca Laurenti, MD, Francesco Zallio, MD, Monia Marchetti, MD PhD, Marina Ruggeri, Paola Omedè, Giovanni Del Poeta, Pr, MD, Valter Gattei, MD, Gianluca Gaidano, MD PhD, Mario Boccadoro, MD, Massimo Massaia, MD, Marta Coscia, MD PhD

Blood (2015) 126 (23): 2925.

https://doi.org/10.1182/blood.V126.23.2925.2925

Published: 2015

Journal Articles

The Mevalonate Metabolic Pathway and the CXCL12/CXCR4 Axis Reciprocally Interact and Are Implicated in Fludarabine Resistance of Chronic Lymphocytic Leukemia Cells

Candida Vitale, MD, Valentina Griggio, MS, Chiara Riganti, MD, Ivana Campia, PhD, Marta Robino, MD, Micol Rigoni, PhD, Patrizia Sciancalepore, MD, Myriam Foglietta, MD PhD, Barbara Castella, PhD, Mario Boccadoro, MD, Massimo Massaia, Marta Coscia, MD PhD

Blood (2014) 124 (21): 833.

https://doi.org/10.1182/blood.V124.21.833.833

Published: 2014

Journal Articles

The Mevalonate Pathway and Downstream Signal Transducers As Therapeutic Targets to Overcome Multidrug Resistance in Chronic Lymphocytic Leukemia (CLL)

Marta Coscia, MD, PhD, Micol Rigoni, PhD, Chiara Riganti, MD, Candida Vitale, MD, Ivana Campia, PhD, Valentina Griggio, PhD, Myriam Foglietta, MD, Barbara Castella, PhD, Patrizia Sciancalepore, MD, Maria Elisa Canepari, MD, Marta Robino, Daniela Drandi, PhD, Marco Ladetto, MD, Amalia Bosia, MD, Mario Boccadoro, MD, Massimo Massaia, MD

Blood (2012) 120 (21): 3881.

https://doi.org/10.1182/blood.V120.21.3881.3881

Published: 2012

Journal Articles

The Mevalonate Pathway As a Metabolic Target to Circumvent Multidrug-Resistance in Chronic Lymphocytic Leukemia Cells

Marta Coscia, MD, PhD, Micol Rigoni, PhD, Chiara Riganti, MD, Ivana Campia, PhD, Candida Vitale, MD, Valentina Griggio, PhD, Silvia Peola, PhD, Barbara Castella, PhD, Patrizia Sciancalepore, MD, Daniela Drandi, PhD, Marco Ladetto, MD, Amalia Bosia, MD, Mario Boccadoro, MD, Massimo Massaia, MD

Blood (2011) 118 (21): 735.

https://doi.org/10.1182/blood.V118.21.735.735

Published: 2011

Journal Articles

The Defective Proliferation of Vgamma9Vdelta2 T Cells to Zoledronic Acid In Chronic Lymphocytic Leukemia (CLL) Is a Powerful Time to First Treatment (TFT) Predictor Associated with the IGHV Mutational Status

Marta Coscia, MD, PhD, Candida Vitale, MD, Silvia Peola, PhD, Chiara Riganti, MD, Daniela Angelini, PhD, Myriam Foglietta, MD, Francesca Pantaleoni, PhD, Giorgia Matta, MD, Sabina Chiaretti, MD, Anna Guarini, PhD, Daniela Drandi, PhD, Marco Ladetto, MD, Amalia Bosia, MD, Luca Battistini, MD, Robin Foà, MD, Mario Boccadoro, MD, Jean-Jacques Fournié, PhD, Massimo Massaia, MD

Blood (2010) 116 (21): 3602.

https://doi.org/10.1182/blood.V116.21.3602.3602

Published: 2010

Journal Articles

IGHV Unmutated Chronic Lymphocytic Leukemia (CLL) B Cells Are More Susceptible to Spontaneous Apoptosis Than Mutated CLL B Cells and Are Subject to the Anti-Apoptotic Effect of Environmental Signals

Marta Coscia, MD, PhD, Francesca Pantaleoni, PhD, Chiara Riganti, MD, Candida Vitale, MD, Micol Rigoni, PhD, Silvia Peola, PhD, Daniela Drandi, PhD, Barbara Castella, PhD, Marina Ruggeri, PhD, Paola Omedè, MD, Marco Ladetto, MD, Amalia Bosia, MD, Mario Boccadoro, MD, Massimo Massaia, MD

Blood (2010) 116 (21): 2431.

https://doi.org/10.1182/blood.V116.21.2431.2431

Published: 2010

Journal Articles

Differential Effects of Microenvironmental Elements On Tumor Cells Survival in Chronic Lymphocytic Leukemia Patient Subsets with Good or Poor Prognosis.

Marta Coscia, MD, Francesca Pantaleoni, PhD, Chiara Riganti, MD, Micol Rigoni, PhD, Candida Vitale, MD, Silvia Peola, PhD, Daniela Drandi, Marco Ladetto, Amalia Bosia, MD, Mario Boccadoro, Massimo Massaia, MD

Blood (2009) 114 (22): 2333.

https://doi.org/10.1182/blood.V114.22.2333.2333

Published: 2009

Journal Articles

Phenotypic and Functional Features of Vγ9/Vδ2 T Cells in Chronic Lymphocytic Leukemia Are Strongly Correlated with the Mutational Status of the Immunoglobulin Heavy Chain Variable Region (IgVH) and Metabolic Activity of the Mevalonate Pathway in Tumor Cells.

Marta Coscia, MD, Silvia Peola, PhD, Giorgia Matta, MD, Francesca Pantaleoni, PhD, Myriam Foglietta, MD, Daniela Angelini, PhD, Sabina Chiaretti, MD, Chiara Riganti, MD, Anna Guarini, PhD, Daniela Drandi, PhD, Marco Ladetto, MD, Amalia Bosia, MD, Robin Foà, MD, Luca Battistini, MD, Mario Boccadoro, MD, Jean Jacques Fournie, PhD, Massimo Massaia, MD

Blood (2007) 110 (11): 1131.

https://doi.org/10.1182/blood.V110.11.1131.1131

Published: 2007

NARROW

Selinexor in Combination with Chemotherapy or Idelalisib Elicits a Synergistic Cytotoxic Effect in Primary CLL Cells, Also Overcoming Intrinsic and Stromal Cells-Mediated Fludarabine Resistance

ATP-Binding-Cassette A1 Regulates Extracellular Isopentenyl Pyrophosphate Release and Vγ9Vδ2 T-Cell Activation By Dendritic Cells

HIF-1α Upregulation in TP53 Disrupted Chronic Lymphocytic Leukemia Cells and Its Potential Role As a Therapeutic Target

The Hypoxia-Inducible Factor-1alpha Is Constitutively Upregulated in TP53 Disrupted CLL Cells: A Potential Target to Overcome Fludarabine Resistance

The Mevalonate Metabolic Pathway and the CXCL12/CXCR4 Axis Reciprocally Interact and Are Implicated in Fludarabine Resistance of Chronic Lymphocytic Leukemia Cells

The Mevalonate Pathway and Downstream Signal Transducers As Therapeutic Targets to Overcome Multidrug Resistance in Chronic Lymphocytic Leukemia (CLL)

The Mevalonate Pathway As a Metabolic Target to Circumvent Multidrug-Resistance in Chronic Lymphocytic Leukemia Cells

The Defective Proliferation of Vgamma9Vdelta2 T Cells to Zoledronic Acid In Chronic Lymphocytic Leukemia (CLL) Is a Powerful Time to First Treatment (TFT) Predictor Associated with the IGHV Mutational Status

IGHV Unmutated Chronic Lymphocytic Leukemia (CLL) B Cells Are More Susceptible to Spontaneous Apoptosis Than Mutated CLL B Cells and Are Subject to the Anti-Apoptotic Effect of Environmental Signals

Differential Effects of Microenvironmental Elements On Tumor Cells Survival in Chronic Lymphocytic Leukemia Patient Subsets with Good or Poor Prognosis.

Phenotypic and Functional Features of Vγ9/Vδ2 T Cells in Chronic Lymphocytic Leukemia Are Strongly Correlated with the Mutational Status of the Immunoglobulin Heavy Chain Variable Region (IgVH) and Metabolic Activity of the Mevalonate Pathway in Tumor Cells.

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American Society of Hematology

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American Society of Hematology

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