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Journal Articles

AAV8-Specific Immune Adsorption Column: A Treatment Option for Patients with Pre-Existing Anti-AAV8 Neutralizing Antibodies

Anita Kruzik, PhD, Roland Raim, PhD, Dirk Voelkel, PhD, Markus Weiller, PhD, Werner Hoellriegl, PhD, Friedrich Scheiflinger, Hanspeter Rottensteiner, Birgit M Reipert, PhD, Maurus de la Rosa

Blood (2019) 134 (Supplement_1): 5922.

https://doi.org/10.1182/blood-2019-126730

Published: 2019

Journal Articles

The Factor VIII Variant X5 Enhances Hemophilia a Gene Therapy Efficiency By Its Improved Secretion

Franziska Horling, PhD, Johannes Lengler, PhD, Wenjing Cao, PhD, Biao Dong, PhD, Bagirath Gangadharan, Maurus De La Rosa, PhD, Werner Hoellriegl, PhD, Birgit M Reipert, PhD, Friedrich Scheiflinger, Weidong Xiao, PhD, Hanspeter Rottensteiner

Blood (2019) 134 (Supplement_1): 3356.

https://doi.org/10.1182/blood-2019-126489

Published: 2019

Journal Articles

Appearance of High-Affinity Antibodies Precedes Clinical Diagnosis of FVIII Inhibitors - Preliminary Analysis from the Hemophilia Inhibitor PUP Study (HIPS)

Birgit M Reipert, PhD, Bagirath Gangadharan, PhD, Christoph J Hofbauer, PhD, Fritz Scheiflinger, PhD, Joel Bowen, Elizabeth Donnachie, PhD, Karen Fijvandraat, MD, Ralph A. Gruppo, MD, Jenny Klintman, MD PhD, Christoph Male, MD, Catherine E. McGuinn, MD, Shannon L. Meeks, MD, Michael Recht, MD PhD, M V Ragni, MD, Hassan M Yaish, Elena Santagostino, MD PhD, Deborah L Brown, MD

Blood (2016) 128 (22): 328.

https://doi.org/10.1182/blood.V128.22.328.328

Published: 2016

Journal Articles

Immunogenicity of BAX 855 in Previously Treated Patients with Congenital Severe Hemophilia Α

Frank Michael Horling, PhD, Peter Allacher, PhD, Herwig Koppensteiner, PhD, Werner Engl, PhD Cstat, Fritz Scheiflinger, PhD, Brigitt E. Abbuehl, MD, Birgit M Reipert, PhD

Blood (2016) 128 (22): 2594.

https://doi.org/10.1182/blood.V128.22.2594.2594

Published: 2016

Journal Articles

Immunization Against Influenza but Not MMR Modulates the Anti-Factor VIII Immune Response in Hemophilia Α Mice

Jesse Lai, BSc, Paul C. Moorehead, MDMS, MSc, Kate Sponagle, Katharina Nora Steinitz, PhD, Birgit M Reipert, PhD, Christine Hough, PhD, David Lillicrap, MD

Blood (2014) 124 (21): 1501.

https://doi.org/10.1182/blood.V124.21.1501.1501

Published: 2014

Journal Articles

Administration of Dexamethasone during Initial Exposure to Factor VIII Induces Durable and Antigen-Specific Tolerance to Factor VIII in Hemophilia Α Mice with a Humanized Major Histocompatibility Complex II Transgene

Paul C. Moorehead, MDMS, MSc, Maria T. Georgescu, BScH, Alice S. van Velzen, MD, Kate Sponagle, Barbara Vidal, MSc, Birgit M. Reipert, PhD, Katharina Nora Steinitz, PhD, Christine Hough, PhD, David Lillicrap, MD

Blood (2014) 124 (21): 1489.

https://doi.org/10.1182/blood.V124.21.1489.1489

Published: 2014

Journal Articles

Administration of Dexamethasone during Initial Exposure to Factor VIII Prevents the Development of Anti-Factor VIII Antibodies and Increases the Proportion of Thymic but Not Splenic Regulatory T Cells in the Exon 16 Knockout C57Bl6 Hemophilia Α Mouse Model

Maria T. Georgescu, BScH, Paul C. Moorehead, MDMS, MSc, Kate Sponagle, Birgit M. Reipert, PhD, Christine Hough, PhD, David Lillicrap, MD

Blood (2014) 124 (21): 237.

https://doi.org/10.1182/blood.V124.21.237.237

Published: 2014

Journal Articles

Surgical Injury Alone Does Not Provoke the Development of Factor VIII Inhibitors in Mouse Models of Hemophilia A

Paul C Moorehead, MD, MS, Braden Waters, PhD, Kate Sponagle, Katharina Nora Steinitz, PhD, Birgit M Reipert, PhD, David Lillicrap, MD

Blood (2012) 120 (21): 627.

https://doi.org/10.1182/blood.V120.21.627.627

Published: 2012

Journal Articles

Preclinical Immunogenicity Assessment of Baxter‘s Longer-Acting FVIII Candidate BAX 855 Using Novel Preclinical Models,

Frank M Horling, PhD, Sandra Schwele, PhD, Christian Lubich, Rafi U Ahmad, PhD, Markus Weiller, PhD, Margit Spatzenegger, Hans Peter Schwarz, MD, Birgit M Reipert, PhD

Blood (2011) 118 (21): 3323.

https://doi.org/10.1182/blood.V118.21.3323.3323

Published: 2011

Journal Articles

Preclinical Immunogenicity Assessment of Baxter‘s Recombinant Factor VIIa,

Frank M Horling, PhD, Christine Lenk, Rafi Uddin Ahmad, PhD, Markus Weiller, PhD, Maria Schuster, DVM, Hans Peter Schwarz, MD, Birgit M Reipert, PhD

Blood (2011) 118 (21): 3327.

https://doi.org/10.1182/blood.V118.21.3327.3327

Published: 2011

Journal Articles

Deciphering of CD4 + T Cell Subsets Involved in Maintenance and Break of Immune Tolerance in a Humanized Mouse Model That Is Immune Tolerant to Human FVII

Christine Lenk, Markus Pasztorek, Markus Weiller, PhD, Rafi Uddin Ahmad, PhD, Hans Peter Schwarz, MD, Friedrich Scheiflinger, PhD, Birgit M Reipert, PhD, Maurus de la Rosa, PhD

Blood (2011) 118 (21): 2188.

https://doi.org/10.1182/blood.V118.21.2188.2188

Published: 2011

Journal Articles

Detection of Non Inhibitory Binding Antibodies to Von Willebrand Factor Affecting the Clearance of VWF:Ag in Von Willebrand Disease

Blood (2011) 118 (21): 2275.

https://doi.org/10.1182/blood.V118.21.2275.2275

Published: 2011

Journal Articles

Induction and Break of Immune Tolerance to Human FVIII in a HLA-DRB1*1501 Humanized Hemophilic Mouse Model

Katharina Nora Steinitz, PhD, Brigitte Binder, Christian Lubich, Rafi Uddin Ahmad, PhD, Markus Weiller, PhD, Maurus de la Rosa, PhD, Hans Peter Schwarz, MD, Friedrich Scheiflinger, PhD, Birgit M Reipert, PhD

Blood (2011) 118 (21): 2280.

https://doi.org/10.1182/blood.V118.21.2280.2280

Published: 2011

Journal Articles

New Early Prophylaxis Regimen That Avoids Immunological Danger Signals Can Reduce Factor Eight (FVIII) Inhibitor Development Independent From Product Type Used.

Guenter K.H. Auerswald, MD, Christoph Bidlingmaier, Werner Engl, Heidi Chehadeh, Birgit M Reipert, PhD, Karin Kurnik, MD

Blood (2009) 114 (22): 221.

https://doi.org/10.1182/blood.V114.22.221.221

Published: 2009

Journal Articles

Agonist for Toll-Like Receptor (TLR) 9 Amplifies as Well as Inhibits the Differentiation of FVIII-Specific Memory B Cells into Antibody-Producing Plasma Cells in Vitro and in Vivo.

Peter Allacher, Christina Hausl, PhD, Aniko Ginta Pordes, Rafi Uddin Ahmad, PhD, Hartmut J Ehrlich, MD, Hans Peter Schwarz, MD, Birgit M Reipert, PhD

Blood (2008) 112 (11): 3382.

https://doi.org/10.1182/blood.V112.11.3382.3382

Published: 2008

Journal Articles

Immune Tolerance to Human Factor VIII Induced by Liver-Specific Expression of a Human Factor VIII Transgene in Hemophilic Mice.

Pauline van Helden, PhD, Maria Sasgary, PhD, Sabine Unterthurner, Mag, Maria Schuster, PhD, Gerhard Antoine, PhD, Klaus Zimmermann, PhD, Rafi Uddin Ahmad, PhD, Eva M Muchitsch, PhD, Hartmut J Ehrlich, MD, Hans Peter Schwarz, MD, Birgit M Reipert, PhD

Blood (2008) 112 (11): 3387.

https://doi.org/10.1182/blood.V112.11.3387.3387

Published: 2008

Journal Articles

Requirements for Co-Stimulation in T-Cell Dependent and T-Cell Independent Re-Stimulation of FVIII-Specific Memory B Cells

Aniko Ginta Pordes, Christina Hausl, PhD, Peter Allacher, Rafi Uddin Ahmad, PhD, Eva M Muchitsch, PhD, Hartmut J Ehrlich, MD, Hans Peter Schwarz, MD, Birgit M Reipert, PhD

Blood (2008) 112 (11): 238.

https://doi.org/10.1182/blood.V112.11.238.238

Published: 2008

Journal Articles

T-Cell-Independent Re-Stimulation of FVIII-Specific Memory B Cells Requires Help from Activated Plasmacytoid Dendritic Cells.

Aniko Ginta Pordes, Christina Hausl, PhD, Peter Allacher, Rafi U. Ahmad, PhD, Bernhard Baumgartner, PhD, Hans Peter Schwarz, MD, Hartmut Ehrlich, MD, Birgit M. Reipert, PhD

Blood (2007) 110 (11): 1155.

https://doi.org/10.1182/blood.V110.11.1155.1155

Published: 2007

Journal Articles

Single-Cell Analysis of FVIII-Specific Memory B Cells in Murine Hemophilia A.

Christina Hausl, PhD, Rafi U. Ahmad, PhD, Bernhard Baumgartner, PhD, Hans Peter Schwarz, MD, Hartmut Ehrlich, MD, Birgit M. Reipert, PhD

Blood (2007) 110 (11): 1157.

https://doi.org/10.1182/blood.V110.11.1157.1157

Published: 2007

Journal Articles

Naturally Occurring Regulatory T Cells Modulate Immune Responses Against Exogenous Factor VIII in Hemophilic Balb/c Mice but Not in C57BL/6J Mice.

Christina Hausl, PhD, Josenato Ilas, Christian Lubich, Rafi U. Ahmad, PhD, Eva M. Muchitsch, PhD, Hartmut Ehrlich, MD, Hans Peter Schwarz, MD, Birgit M. Reipert, PhD

Blood (2007) 110 (11): 1160.

https://doi.org/10.1182/blood.V110.11.1160.1160

Published: 2007

NARROW

AAV8-Specific Immune Adsorption Column: A Treatment Option for Patients with Pre-Existing Anti-AAV8 Neutralizing Antibodies

The Factor VIII Variant X5 Enhances Hemophilia a Gene Therapy Efficiency By Its Improved Secretion

Appearance of High-Affinity Antibodies Precedes Clinical Diagnosis of FVIII Inhibitors - Preliminary Analysis from the Hemophilia Inhibitor PUP Study (HIPS)

Immunogenicity of BAX 855 in Previously Treated Patients with Congenital Severe Hemophilia Α

Immunization Against Influenza but Not MMR Modulates the Anti-Factor VIII Immune Response in Hemophilia Α Mice

Administration of Dexamethasone during Initial Exposure to Factor VIII Induces Durable and Antigen-Specific Tolerance to Factor VIII in Hemophilia Α Mice with a Humanized Major Histocompatibility Complex II Transgene

Administration of Dexamethasone during Initial Exposure to Factor VIII Prevents the Development of Anti-Factor VIII Antibodies and Increases the Proportion of Thymic but Not Splenic Regulatory T Cells in the Exon 16 Knockout C57Bl6 Hemophilia Α Mouse Model

Surgical Injury Alone Does Not Provoke the Development of Factor VIII Inhibitors in Mouse Models of Hemophilia A

Preclinical Immunogenicity Assessment of Baxter‘s Longer-Acting FVIII Candidate BAX 855 Using Novel Preclinical Models,

Preclinical Immunogenicity Assessment of Baxter‘s Recombinant Factor VIIa,

Deciphering of CD4 + T Cell Subsets Involved in Maintenance and Break of Immune Tolerance in a Humanized Mouse Model That Is Immune Tolerant to Human FVII

Detection of Non Inhibitory Binding Antibodies to Von Willebrand Factor Affecting the Clearance of VWF:Ag in Von Willebrand Disease

Induction and Break of Immune Tolerance to Human FVIII in a HLA-DRB1*1501 Humanized Hemophilic Mouse Model

New Early Prophylaxis Regimen That Avoids Immunological Danger Signals Can Reduce Factor Eight (FVIII) Inhibitor Development Independent From Product Type Used.

Agonist for Toll-Like Receptor (TLR) 9 Amplifies as Well as Inhibits the Differentiation of FVIII-Specific Memory B Cells into Antibody-Producing Plasma Cells in Vitro and in Vivo.

Immune Tolerance to Human Factor VIII Induced by Liver-Specific Expression of a Human Factor VIII Transgene in Hemophilic Mice.

Requirements for Co-Stimulation in T-Cell Dependent and T-Cell Independent Re-Stimulation of FVIII-Specific Memory B Cells

T-Cell-Independent Re-Stimulation of FVIII-Specific Memory B Cells Requires Help from Activated Plasmacytoid Dendritic Cells.

Single-Cell Analysis of FVIII-Specific Memory B Cells in Murine Hemophilia A.

Naturally Occurring Regulatory T Cells Modulate Immune Responses Against Exogenous Factor VIII in Hemophilic Balb/c Mice but Not in C57BL/6J Mice.

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American Society of Hematology

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American Society of Hematology

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