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Journal Articles

Incompletely Activated CD4+ T Cells Induce Granzyme B+ Regulatory B Cells In An Interleukin 21-Dependent Manner

Bernd Jahrsdoerfer, MD, Karen Dahlke, Magdalena Hagn, MD, Kai Sontheimer, Thamara Beyer, Oleg Lunov, Dorit Fabricius, MD, Kyrylo Tron, G. Ulrich Nienhaus, PhD, Thomas Simmet, MD

Blood (2010) 116 (21): 3905.

https://doi.org/10.1182/blood.V116.21.3905.3905

Published: 2010

Journal Articles

Induction of a CTL-Like Phenotype In B-CLL Cells Stimulated with Interleukin 21 and CpG Oligodeoxynucleotides

Bernd Jahrsdoerfer, MD, Sue E Blackwell, Magdalena Hagn, MD, Verena Ebel, Thamara Beyer, Kai Sontheimer, Karen Dahlke, George Weiner, MD, Thomas Simmet, MD

Blood (2010) 116 (21): 3906.

https://doi.org/10.1182/blood.V116.21.3906.3906

Published: 2010

Journal Articles

Activation of Acute Lymphocytic Leukemia Blasts with CpG ODN, IL-4 and CD40 Ligand Facilitates Enhanced Anti-Leukemic CTL Responses

Dorit Fabricius, Lucia Breckerbohm, Manon Queudeville, MD, Angelika Vollmer, Sarah M. Eckhoff, MD, Johanna Pfeil, Gudrun Strauss, PhD, Simone Fulda, MD, Bernd Jahrsdoerfer, MD, Lueder H Meyer, MD, Klaus-Michael Debatin, MD

Blood (2010) 116 (21): 3907.

https://doi.org/10.1182/blood.V116.21.3907.3907

Published: 2010

Journal Articles

Granzyme B Produced by Human Plasmacytoid Dendritic Cells Suppresses T Cell Expansion.

Dorit Fabricius, MD, Angelika Vollmer, Sue Blackwell, Julia Maier, Kai Sontheimer, Thamara Beyer, Birgit Mandel, Oleg Lunov, Kyrylo Tron, G. Ulrich Nienhaus, PhD, Thomas Simmet, MD, Klaus-Michael Debatin, MD, George J Weiner, MD, Bernd Jahrsdoerfer, MD

Blood (2009) 114 (22): 2674.

https://doi.org/10.1182/blood.V114.22.2674.2674

Published: 2009

Journal Articles

CD40 Ligand Determines Whether Interleukin 21 Induces Differentiation of Human B Cells Into Plasma Cells or Into Granzyme B-Secreting Cytotoxic Cells.

Bernd Jahrsdoerfer, MD, Magdalena Hagn, MD, Kai Sontheimer, Elisabeth Schwesinger, Verena Ebel, Julia Maier, Thamara Beyer, Dorit Fabricius, MD, Oleg Lunov, Kyrylo Tron, Tatjana Syrovets, PhD, Thomas FE Barth, MD, G. Ulrich Nienhaus, PhD, Thomas Simmet, MD

Blood (2009) 114 (22): 2675.

https://doi.org/10.1182/blood.V114.22.2675.2675

Published: 2009

Journal Articles

Viral Antigens Trigger Granzyme B Secretion by Human CD5+ B1 Cells in the Presence of Interleukin 21.

Kai Sontheimer, Sue Blackwell, Magdalena Hagn, MD, Verena Ebel, Thamara Beyer, Thomas Simmet, MD, Bernd Jahrsdoerfer, MD

Blood (2009) 114 (22): 4729.

https://doi.org/10.1182/blood.V114.22.4729.4729

Published: 2009

Journal Articles

Stimulation of B-CLL Cells with Interleukin 21 and Toll Like Receptor Agonists Induces a CTL-Like Transcriptional Profile.

Magdalena Hagn, MD, Verena Ebel, Kai Sontheimer, Thamara Beyer, Sue E. Blackwell, Thomas Simmet, MD, George J. Weiner, MD, Bernd Jahrsdoerfer, MD

Blood (2009) 114 (22): 3685.

https://doi.org/10.1182/blood.V114.22.3685.3685

Published: 2009

Journal Articles

Specific Induction of Granzyme B in Human B Cells by Viral Antigens.

Magdalena Hagn, MD, Julia Maier, Tatjana Syrovets, PhD, Thomas Simmet, MD, Bernd Jahrsdoerfer, MD

Blood (2008) 112 (11): 1556.

https://doi.org/10.1182/blood.V112.11.1556.1556

Published: 2008

Journal Articles

Naïve B Cells Differentiate into Highly Activated Granzyme B-Secreting B Cells in Response to Interleukin 21 and B Cell Receptor Stimulation

Elisabeth Schwesinger, Magdalena Hagn, MD, Thomas Simmet, MD, Bernd Jahrsdoerfer, MD

Blood (2008) 112 (11): 2555.

https://doi.org/10.1182/blood.V112.11.2555.2555

Published: 2008

Journal Articles

Human B Cell Lines and Primary B Cells Actively Secrete Granzyme B in Response to IL-2 Family Cytokines.

Bernd Jahrsdoerfer, MD, Sue E. Blackwell, Thomas Simmet, MD, George J. Weiner, MD

Blood (2007) 110 (11): 1340.

https://doi.org/10.1182/blood.V110.11.1340.1340

Published: 2007

Journal Articles

Interleukin 21-Based Therapy Can Induce Human B Cells To Produce Granzyme B and Express Other Features of Cytotoxic Lymphocytes.

Bernd Jahrsdoerfer, MD, Sue M. Blackwell, George J. Weiner, MD

Blood (2006) 108 (11): 3886.

https://doi.org/10.1182/blood.V108.11.3886.3886

Published: 2006

Journal Articles

IL-21 Plus CpG ODN Induces Granzyme B-Dependent Induction of Apoptosis in CD5-Positive B Cells Including B-CLL Cells.

Sue E. Blackwell, Bernd Jahrsdoerfer, MD, James E. Wooldridge, MD, Jian Huang, Melinda W. Andreski, Laura S. Jacobus, Christiana M. Taylor, George J. Weiner, MD

Blood (2006) 108 (11): 2823.

https://doi.org/10.1182/blood.V108.11.2823.2823

Published: 2006

Journal Articles

IL-21 and CpG ODN Are Synergistic in Their Ability To Induce Apoptosis of Chronic Lymphocytic Leukemia (CLL) Cells and Benign B1 Cells.

Bernd Jahrsdoerfer, MD, Sue E. Blackwell, James E. Wooldridge, MD, Melinda W. Andreski, Laura S. Jacobus, Christiana M. Taylor, George J. Weiner, MD

Blood (2005) 106 (11): 5022.

https://doi.org/10.1182/blood.V106.11.5022.5022

Published: 2005

NARROW

Incompletely Activated CD4+ T Cells Induce Granzyme B+ Regulatory B Cells In An Interleukin 21-Dependent Manner

Induction of a CTL-Like Phenotype In B-CLL Cells Stimulated with Interleukin 21 and CpG Oligodeoxynucleotides

Activation of Acute Lymphocytic Leukemia Blasts with CpG ODN, IL-4 and CD40 Ligand Facilitates Enhanced Anti-Leukemic CTL Responses

Granzyme B Produced by Human Plasmacytoid Dendritic Cells Suppresses T Cell Expansion.

CD40 Ligand Determines Whether Interleukin 21 Induces Differentiation of Human B Cells Into Plasma Cells or Into Granzyme B-Secreting Cytotoxic Cells.

Viral Antigens Trigger Granzyme B Secretion by Human CD5+ B1 Cells in the Presence of Interleukin 21.

Stimulation of B-CLL Cells with Interleukin 21 and Toll Like Receptor Agonists Induces a CTL-Like Transcriptional Profile.

Specific Induction of Granzyme B in Human B Cells by Viral Antigens.

Naïve B Cells Differentiate into Highly Activated Granzyme B-Secreting B Cells in Response to Interleukin 21 and B Cell Receptor Stimulation

Human B Cell Lines and Primary B Cells Actively Secrete Granzyme B in Response to IL-2 Family Cytokines.

Interleukin 21-Based Therapy Can Induce Human B Cells To Produce Granzyme B and Express Other Features of Cytotoxic Lymphocytes.

IL-21 Plus CpG ODN Induces Granzyme B-Dependent Induction of Apoptosis in CD5-Positive B Cells Including B-CLL Cells.

IL-21 and CpG ODN Are Synergistic in Their Ability To Induce Apoptosis of Chronic Lymphocytic Leukemia (CLL) Cells and Benign B1 Cells.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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