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Journal Articles

The Mechanisms By Which Mutant-NPM1 Uncouples Differentiation from Proliferation Are Reversed By Several Drugs, Enabling Rational Multi-Component Non-Cytotoxic Differentiation Therapy

Xiaorong Gu, PhD, Quteba Ebrahem, MD, Reda Z. Mahfouz, MD PhD, Metis Hasipek, PhD, Francis Enane, PhD, Tomas Radivoyevitch, Nicolas Rapin, PhDMSc, Bartlomiej P. Przychodzen, MSc, Ramesh Balusu, PhD, Claudiu V Cotta, David Wald, MD PhD, Zhenbo Hu, MD PhD, Yosef Landesman, PhD, Maria Paola Martelli, MD PhD, Brunangelo Falini, MD, Hetty E. Carraway, MD MBA, Jaroslaw P. Maciejewski, PhD MD FACP, Babal K Jha, PhD, Yogenthiran Saunthararajah, MD

Blood (2017) 130 (Supplement 1): 878.

https://doi.org/10.1182/blood.V130.Suppl_1.878.878

Published: 2017

Journal Articles

Distinct Clinical Phenotypes of Patients with Myeloid Neoplasms Carrying SF3B1 Hotspot Mutations

Blood (2017) 130 (Supplement 1): 2961.

https://doi.org/10.1182/blood.V130.Suppl_1.2961.2961

Published: 2017

Journal Articles

Model Heterogeneity in Predicting Outcomes of Patients with Myelodysplastic Syndromes (MDS)

Karam Al-Issa, MD, Yazan F. Madanat, MD, Sudipto Mukherjee, MD PhD MPH, Cassandra M. Hirsch, BS, Aaron T. Gerds, MDMS, Nour Abuhadra, MD, Ahed Makhoul, MD, Hassan Awada, MD, Mohammad Fahad B Asad, MD MBBS, Abhinav Goyal, MD, Anjali S. Advani, MD, Teodora Kuzmanovic, BA, Bartlomiej P. Przychodzen, MSc, Hetty E. Carraway, MD MBA, Jaroslaw P. Maciejewski, PhD MD FACP, Mikkael A. Sekeres, MD MS, Aziz Nazha, MD

Blood (2017) 130 (Supplement 1): 2972.

https://doi.org/10.1182/blood.V130.Suppl_1.2972.2972

Published: 2017

Journal Articles

Distinct Genomic Associations to Predict Acute Myeloid Leukemia (AML) Progression from Myelodysplastic Syndromes (MDS)

Yazan F. Madanat, MD, Mikkael A. Sekeres, MD MS, Karam Al-Issa, MD, Cassandra M. Hirsch, BS, Sudipto Mukherjee, MD PhD MPH, Aaron T. Gerds, MDMS, Nour Abuhadra, MD, Babal K Jha, PhD, Vera Adema, PhD, Anjali S. Advani, MD, Yasunobu Nagata, MD PhD, Teodora Kuzmanovic, BA, Bartlomiej P. Przychodzen, MSc, Hetty E. Carraway, MD MBA, Jaroslaw P. Maciejewski, PhD MD FACP, Aziz Nazha, MD

Blood (2017) 130 (Supplement 1): 4245.

https://doi.org/10.1182/blood.V130.Suppl_1.4245.4245

Published: 2017

Journal Articles

How Somatic Mutations Carve Morphologic Imprint in MDS?

Abhinav Goyal, MD, Mohammad Fahad B Asad, MD MBBS, Hassan Awada, MD, Mai Aly, MD, Cassandra M. Hirsch, BS, Bartlomiej P. Przychodzen, MSc, Tomas Radivoyevitch, PhD, Aziz Nazha, MD, Sudipto Mukherjee, MD PhD MPH, Mikkael A. Sekeres, MD MS, Jaroslaw P. Maciejewski, PhD MD FACP, Yasunobu Nagata, MD PhD

Blood (2017) 130 (Supplement 1): 2949.

https://doi.org/10.1182/blood.V130.Suppl_1.2949.2949

Published: 2017

Journal Articles

Genomic Biomarkers to Predict Response to Hypomethylating Agents in Patients with Myelodysplastic Syndromes (MDS)

Aziz Nazha, MD, Mikkael A. Sekeres, MD MS, Rafael Bejar, MD PhD, Rami S. Komrokji, MD, John Barnard, PhD, Karam Al-Issa, MD, Bartlomiej P. Przychodzen, MSc, Cassandra M. Hirsch, BS, David P. Steensma, MD, Amy E. DeZern, MD, Gail J. Roboz, MD, Guillermo Garcia-Manero, MD, Benjamin L. Ebert, MD PhD, Jaroslaw P. Maciejewski, PhD MD FACP

Blood (2017) 130 (Supplement 1): 157.

https://doi.org/10.1182/blood.V130.Suppl_1.157.157

Published: 2017

Journal Articles

TET2 and MSH6: A Novel Role for MMR in the Pathogenesis of Myeloid Malignancies

Edward F Greenberg, MD, Cassandra M. Hirsch, BS, Feng Pan, PhD, Babal K Jha, PhD, Yihong Guan, PhD, Valeria Visconte, PhD, Dewen You, PhD, Guangbo Qu, PhD, Amy Graham, Bartlomiej P. Przychodzen, MSc, Thomas Laframboise, PhD, Hideki Makishima, MD PhD, Daniel Gackowski, PhD, Ryszard Ólinski, Professor, Yu-Wei Cheng, PhD, Mikkael A. Sekeres, MD MS, Mingjiang Xu, MDPhD, Jaroslaw P. Maciejewski, PhD MD FACP

Blood (2017) 130 (Supplement 1): 1668.

https://doi.org/10.1182/blood.V130.Suppl_1.1668.1668

Published: 2017

Journal Articles

Germline SAMD9 and SAMD9L Alterations in Adult Myelodysplastic Syndromes

Yasunobu Nagata, MD PhD, Bartlomiej P. Przychodzen, MSc, Cassandra M. Hirsch, BS, Hideki Makishima, MD PhD, Victor Pastor Loyola, MSc, Babal K Jha, PhD, Teodora Kuzmanovic, BA, Tomas Radivoyevitch, PhD, Vera Adema, PhD, Kenichi Yoshida, MD PhD, Samuel Li, BA, Francesc Sole, PhD, Thomas Laframboise, PhD, Rabi Hanna, MD, Mikkael A. Sekeres, MD MS, Seishi Ogawa, MD PhD, Marcin W. Wlodarski, MD PhD, Jorg Cammenga, MD, Jaroslaw P. Maciejewski, PhD MD FACP

Blood (2017) 130 (Supplement 1): 1670.

https://doi.org/10.1182/blood.V130.Suppl_1.1670.1670

Published: 2017

Journal Articles

Chemotherapy and Radiation Results in Distinct Patterns of Somatic Mutations in Subsequent Myeloid Disease

Teodora Kuzmanovic, BA, Tomas Radivoyevitch, PhD, Srinivasa Reddy Sanikommu, MD, Bhumika J. Patel, MD, Yasunobu Nagata, MD PhD, Cassandra M. Hirsch, BS, Bartlomiej P. Przychodzen, MSc, Sudipto Mukherjee, MD PhD MPH, Anjali S. Advani, MD, Aziz Nazha, MD, Aaron T. Gerds, MDMS, Hetty E. Carraway, MD MBA, Mikkael A. Sekeres, MD MS, Jaroslaw P. Maciejewski, PhD MD FACP

Blood (2017) 130 (Supplement 1): 1673.

https://doi.org/10.1182/blood.V130.Suppl_1.1673.1673

Published: 2017

Journal Articles

Evolution in Myeloid Neoplasms Clonal Architecture Post Allogeneic Hematopoietic Cell Transplantation

Blood (2017) 130 (Supplement 1): 1682.

https://doi.org/10.1182/blood.V130.Suppl_1.1682.1682

Published: 2017

Journal Articles

Therapeutic Targeting of GLI1 in Acute Myeloid Leukemia

Metis Hasipek, PhD, Sayer Al-Harbi, PhD, James G Phillips, PhD, Bartlomiej P. Przychodzen, MSc, Alek Nielsen, BS, Yihong Guan, PhD, Dale Grabowski, BS, Phillip J Maciejewski, Aziz Nazha, MD, Hetty E. Carraway, MD MBA, Jaroslaw P. Maciejewski, PhD MD FACP, Babal K Jha, PhD

Blood (2017) 130 (Supplement 1): 2654.

https://doi.org/10.1182/blood.V130.Suppl_1.2654.2654

Published: 2017

Journal Articles

Surveillance of the Immune Repertoire of Aplastic Anemia Patients Using Deep Sequencing

Cassandra M. Hirsch, BS, Michael J. Clemente, Valeria Visconte, PhD, Taha Bat, Bartlomiej P. Przychodzen, MSc, Tomas Radivoyevitch, PhD, Vera Adema, PhD, Yasunobu Nagata, MD PhD, Hetty E. Carraway, MD MBA, Mikkael A. Sekeres, MD MS, Babal K Jha, PhD, Sudipto Mukherjee, MD PhD MPH, Thomas Laframboise, PhD, Jaroslaw P. Maciejewski, PhD MD FACP

Blood (2017) 130 (Supplement 1): 2454.

https://doi.org/10.1182/blood.V130.Suppl_1.2454.2454

Published: 2017

Journal Articles

Clonal Architecture of TET2 Mutations Influences the Clinical Phenotype of Patients with Myeloid Neoplasms

Cassandra M. Hirsch, BS, Aziz Nazha, MD, Kneen Kassy, Manja Meggendorfer, PhD, Bartlomiej P. Przychodzen, MSc, Niroshan Nadarajah, Vera Adema, PhD, Yasunobu Nagata, MD PhD, Valeria Visconte, PhD, Hetty E. Carraway, MD MBA, Mikkael A. Sekeres, MD MS, Ryszard Ólinski, Professor, Sudipto Mukherjee, MD PhD MPH, Babal K Jha, PhD, Thomas Laframboise, PhD, Tomas Radivoyevitch, PhD, Torsten Haferlach, MD, Jaroslaw P. Maciejewski, PhD MD FACP

Blood (2017) 130 (Supplement 1): 4228.

https://doi.org/10.1182/blood.V130.Suppl_1.4228.4228

Published: 2017

Journal Articles

Activation of Autophagy in Models of SF3B1 Mutant MDS

Blood (2017) 130 (Supplement 1): 4230.

https://doi.org/10.1182/blood.V130.Suppl_1.4230.4230

Published: 2017

Journal Articles

PPM1D Mutations and up Modulation Phenocopy TP53 Lesions in Myeloid Neoplasms

Reem Elagooz, MS, MD, Mai Aly, MD MS, Cassandra M. Hirsch, BS, Bartlomiej P. Przychodzen, MSc, Teodora Kuzmanovic, BA, Tomas Radivoyevitch, Valeria Visconte, PhD, Sudipto Mukherjee, MD PhD MPH, Hetty E. Carraway, MD MBA, Mikkael A. Sekeres, MD MS, Aziz Nazha, MD, Jaroslaw P. Maciejewski, PhD MD FACP, Yasunobu Nagata, MD PhD

Blood (2017) 130 (Supplement 1): 4233.

https://doi.org/10.1182/blood.V130.Suppl_1.4233.4233

Published: 2017

Journal Articles

Mutational Burden before and after Allogeneic Hematopoietic Cell Transplantation (HCT) in Patients with Acute Myeloid Leukemia (AML)

Aziz Nazha, MD, Betty K. Hamilton, MD, Mikkael A. Sekeres, MD MS, Sudipto Mukherjee, MD PhD MPH, Aaron T. Gerds, MDMS, Rabi Hanna, MD, Cassandra M. Hirsch, BS, Teodora Kuzmanovic, BA, Karam Al-Issa, MD, Bartlomiej P. Przychodzen, MSc, Ronald Sobecks, MD, Matt Kalaycio, MD, Navneet S. Majhail, MD MS, Jaroslaw P. Maciejewski, PhD MD FACP

Blood (2017) 130 (Supplement 1): 3272.

https://doi.org/10.1182/blood.V130.Suppl_1.3272.3272

Published: 2017

Journal Articles

IDH1/2 -Mutated Acute Myeloid Leukemia Has Impaired DNA Damage Response and Is Sensitive to Monotherapy with the PARP Inhibitior Olaparib

Remco J Molenaar, Tomas Radivoyevitch, PhD, Yasunobu Nagata, MD PhD, Bartlomiej P. Przychodzen, MSc, Hideki Makishima, MD PhD, Hetty E. Carraway, MD MBA, Sudipto Mukherjee, MD PhD MPH, Mikkael A. Sekeres, MD MS, Cornelis van Noorden, PhD, Jaroslaw P. Maciejewski, PhD MD FACP

Blood (2017) 130 (Supplement 1): 568.

https://doi.org/10.1182/blood.V130.Suppl_1.568.568

Published: 2017

Journal Articles

High Frequency of Subclonal Myeloid Mutations Can be Found in Large Granular Lymphocyte Leukemia

Elise LeMelle, Cassandra M. Hirsch, BS, Michael Clemente, MS, Srinivasa Reddy Sanikommu, MD, Vera Adema, PhD, Hassan Awada, MD, Bartlomiej P. Przychodzen, MSc, Hetty E. Carraway, MD MBA, Alan Lichtin, MD, Mikkael A. Sekeres, MD MS, Sudipto Mukherjee, MD PhD MPH, Valeria Visconte, PhD, Jaroslaw P. Maciejewski, PhD MD FACP

Blood (2017) 130 (Supplement 1): 1171.

https://doi.org/10.1182/blood.V130.Suppl_1.1171.1171

Published: 2017

Journal Articles

Novel Therapeutic Targets for DNMT3A Mutant Myeloid Neoplasms

Vera Adema, PhD, Suresh K. Balasubramanian, MD, Cassandra M. Hirsch, BS, Bartlomiej P. Przychodzen, MSc, James G Phillips, PhD, Daniel Lindner, MD PhD, Tomas Radivoyevitch, PhD, Sudipto Mukherjee, MD PhD MPH, Aziz Nazha, MD, Hetty E. Carraway, MD MBA, Francesc Sole, PhD, Mikkael A. Sekeres, MD MS, Valeria Visconte, PhD, Jaroslaw P. Maciejewski, PhD MD FACP

Blood (2017) 130 (Supplement 1): 106.

https://doi.org/10.1182/blood.V130.Suppl_1.106.106

Published: 2017

Journal Articles

Patterns of Genomic Associations Can Define Acute Myeloid Leukemia (AML) Phenotype

Aziz Nazha, MD, Mikkael A. Sekeres, MD MS, Karam Al-Issa, MD, Ahed Makhoul, MD, Vera Adema, PhD, Cassandra M. Hirsch, BS, Anjali S. Advani, MD, Bartlomiej P. Przychodzen, MSc, Teodora Kuzmanovic, BA, Babal K Jha, PhD, Aaron T. Gerds, MDMS, Hetty E. Carraway, MD MBA, Sudipto Mukherjee, MD PhD MPH, Matt Kalaycio, MD, Jaroslaw P. Maciejewski, PhD MD FACP

Blood (2017) 130 (Supplement 1): 1409.

https://doi.org/10.1182/blood.V130.Suppl_1.1409.1409

Published: 2017

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The Mechanisms By Which Mutant-NPM1 Uncouples Differentiation from Proliferation Are Reversed By Several Drugs, Enabling Rational Multi-Component Non-Cytotoxic Differentiation Therapy

Distinct Clinical Phenotypes of Patients with Myeloid Neoplasms Carrying SF3B1 Hotspot Mutations

Model Heterogeneity in Predicting Outcomes of Patients with Myelodysplastic Syndromes (MDS)

Distinct Genomic Associations to Predict Acute Myeloid Leukemia (AML) Progression from Myelodysplastic Syndromes (MDS)

How Somatic Mutations Carve Morphologic Imprint in MDS?

Genomic Biomarkers to Predict Response to Hypomethylating Agents in Patients with Myelodysplastic Syndromes (MDS)

TET2 and MSH6: A Novel Role for MMR in the Pathogenesis of Myeloid Malignancies

Germline SAMD9 and SAMD9L Alterations in Adult Myelodysplastic Syndromes

Chemotherapy and Radiation Results in Distinct Patterns of Somatic Mutations in Subsequent Myeloid Disease

Evolution in Myeloid Neoplasms Clonal Architecture Post Allogeneic Hematopoietic Cell Transplantation

Therapeutic Targeting of GLI1 in Acute Myeloid Leukemia

Surveillance of the Immune Repertoire of Aplastic Anemia Patients Using Deep Sequencing

Clonal Architecture of TET2 Mutations Influences the Clinical Phenotype of Patients with Myeloid Neoplasms

Activation of Autophagy in Models of SF3B1 Mutant MDS

PPM1D Mutations and up Modulation Phenocopy TP53 Lesions in Myeloid Neoplasms

Mutational Burden before and after Allogeneic Hematopoietic Cell Transplantation (HCT) in Patients with Acute Myeloid Leukemia (AML)

IDH1/2 -Mutated Acute Myeloid Leukemia Has Impaired DNA Damage Response and Is Sensitive to Monotherapy with the PARP Inhibitior Olaparib

High Frequency of Subclonal Myeloid Mutations Can be Found in Large Granular Lymphocyte Leukemia

Novel Therapeutic Targets for DNMT3A Mutant Myeloid Neoplasms

Patterns of Genomic Associations Can Define Acute Myeloid Leukemia (AML) Phenotype

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