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Journal Articles

BCL10 Gain-of-Function Mutations Aberrantly Induce Canonical and Non-Canonical NF-Kb Activation and Resistance to Ibrutinib in ABC-DLBCL

Min Xia, Liron David, PhD, Matthew Teater, PhD, Ozlem Onder, PhD MSc, Kojo S. J. Elenitoba-Johnson, MD, Lorena Fontan, PhD, Hao Wu, PhD, Ari Melnick, MD

Blood (2020) 136 (Supplement 1): 2–3.

https://doi.org/10.1182/blood-2020-141363

Published: 2020

Journal Articles

Multi-Center Phase II Study of Oral Azacitidine (CC-486) Plus CHOP As Initial Treatment for Peripheral T-Cell Lymphoma (PTCL)

Jia Ruan, MD PhD, Alison J. Moskowitz, MD, Neha Mehta-Shah, MD, Lubomir Sokol, MD PhD, Zhengming Chen, PhD MPH, MS, Riyaad Rahim, Wei Song, Koen Van Besien, MD PhD, Steven M. Horwitz, MD, Sarah C. Rutherford, MD, Morton Coleman, MD FACP, Ari Melnick, MD, Giorgio Inghirami, MD, Leandro Cerchietti, MD, John P. Leonard, MD, Peter Martin, FRCPC, MD MS

Blood (2020) 136 (Supplement 1): 33–34.

https://doi.org/10.1182/blood-2020-136023

Published: 2020

Journal Articles

The Tumor Associated Antigen PRAME Exhibits Dualistic Functions That Are Targetable in Diffuse Large B-Cell Lymphoma

Blood (2020) 136 (Supplement 1): 34.

https://doi.org/10.1182/blood-2020-141168

Published: 2020

Journal Articles

Rationale for Targeting BCL6 in MLL-Rearranged B-ALL

Lai N Chan, PhD, Christian Hurtz, PhD, Huimin Geng, PhD, Erica Ballabio, Gang Xiao, PhD, Gauri Deb, MS, PhD, Haytham Khoury, MD PhD, Scott A. Armstrong, MD PhD, Patricia Ernst, PhD, Ari Melnick, MD, Tom Arthur Milne, PhD, Markus Müschen, MD PhD

Blood (2019) 134 (Supplement_1): 1239.

https://doi.org/10.1182/blood-2019-131565

Published: 2019

Journal Articles

Histone 1 Mutations Drive Lymphomagenesis By Inducing Primitive Stem Cell Functions and Epigenetic Instructions through Profound 3D Re-Organization of the B-Cell Genome

Nevin Yusufova, Matthew R Teater, PhD, Alexey Soshnev, Andreas Kloetgen, Adewola Osunsade, Joseph Conway, Ashley Doane, Arthur Skoultchi, Aristotelis Tsirigos, PhD, Yael David, C. David Allis, PhD, Ethel Cesarman, MD PhD, Ari Melnick, MD

Blood (2019) 134 (Supplement_1): 23.

https://doi.org/10.1182/blood-2019-127774

Published: 2019

Journal Articles

An OCT2 / OCA-B / MEF2B Ternary Complex Controls the Activity and Architecture of an Essential Locus Control Region for Normal and Malignant Germinal Center B-Cells

Johannes C Hellmuth, MD, Chi-Shuen Chu, PhD, Rajat Singh, PhD, Lucy A Skrabanek, PhD, Ashley Doane, Olivier Elemento, PhD, Robert G. Roeder, PhD, Ari Melnick, MD

Blood (2019) 134 (Supplement_1): 24.

https://doi.org/10.1182/blood-2019-130692

Published: 2019

Journal Articles

Chemically Induced Degradation of MALT1 to Treat B-Cell Lymphomas

Lorena Fontan, PhD, John Hatcher, PhD, David Scott, Qi Qiao, Ilkay Us, Guangyan Du, Matthew Durant, Jimmy Wilson, Hao Wu, PhD, Nathanael Gray, Ari Melnick, MD

Blood (2019) 134 (Supplement_1): 2073.

https://doi.org/10.1182/blood-2019-130666

Published: 2019

Journal Articles

Mapping MALT1 Signaling Connectivity Unveils Novel B-Cell Feedback Mechanisms Directing Assembly of Potent Anti-Lymphoma Regimens

Lorena Fontan, PhD, Matthew Durant, Rebecca Goldstein, PhD, Matthew R Teater, PhD, Gabriella Casalena, PhD, Min Xia, PhD, Jimmy Wilson, Ilkay Us, Giorgio Inghirami, MD, Ari Melnick, MD

Blood (2019) 134 (Supplement_1): 173.

https://doi.org/10.1182/blood-2019-130516

Published: 2019

Journal Articles

Dynamic Assembly of a Feedback Complex to Regulate Oncogenic B-Cell Receptor-Signaling

Blood (2019) 134 (Supplement_1): 393.

https://doi.org/10.1182/blood-2019-131270

Published: 2019

Journal Articles

Combined EZH2 and BCL2 Inhibitors As Precision Therapy for Genetically Defined DLBCL Subtypes

Destini Gibbs, Herman Van Besien, BA, Stephenson Regan, Ankur Singh, PhD, Matthew Teater, Ethel Cesarman, MD PhD, Ari Melnick, MD, Lisa Giulino Roth, MD

Blood (2019) 134 (Supplement_1): 304.

https://doi.org/10.1182/blood-2019-126790

Published: 2019

Journal Articles

The Paracaspase MALT1 Acts Independently of Pre-B-Cell Receptor Signaling As a Key Factor in Leukemic Cell Survival in Precursor B-Cell Acute Lymphoblastic Leukemia

Nakhle S. Saba, MD, Jade Meyers, Lorena Fontan, PhD, Ari Melnick, MD, Adrian Wiestner, MD PhD, Patricia Lobelle-Rich, Ekaterina Kim, MS, Jan A. Burger, MD PhD, Yara Mouawad, MD, Prescott L. Deininger, PhD, Francisco Socola, MD, Hana Safah, MD, Erik K Flemington, PhD

Blood (2019) 134 (Supplement_1): 1288.

https://doi.org/10.1182/blood-2019-131376

Published: 2019

Journal Articles

EZH2 Gain-of-Function Mutations Generate a Lymphoma-Permissive Immune Niche

Wendy Béguelin, PhD, Matthew R Teater, PhD, Cem Meydan, PhD, Jude M Phillip, PhD, Ari Melnick, MD

Blood (2019) 134 (Supplement_1): 2768.

https://doi.org/10.1182/blood-2019-132263

Published: 2019

Journal Articles

Wt1 Haploinsufficiency Induces an Age-Dependent Enhancement in Stem Cell Self-Renewal and Cooperates with FLT3-ITD to Drives Leukemogenesis

Elodie Pronier, PhD, Justin T Whitfield, Tiffany Merlinsky, Jihae Ahn, Raajit K. Rampal, MD PhD, Benjamin H Durham, MD BS, Ari Melnick, MD, Ross L. Levine, MD

Blood (2017) 130 (Supplement 1): 1214.

https://doi.org/10.1182/blood.V130.Suppl_1.1214.1214

Published: 2017

Journal Articles

Genetically-Defined AML Subgroups Represent Diverse Epigenetic Heterogeneity Landscape

Sheng Li, PhD, Xiaowen Chen, PhD, Jihui Wang, MS, Cem Meydan, PhD, Jacob L Glass, MDPhD, Alan H. Shih, MD PhD, Peter J.M. Valk, PhD, Ruud Delwel, PhD, Ross L. Levine, MD, Christopher Mason, PhD, Ari Melnick, MD

Blood (2017) 130 (Supplement 1): 243.

https://doi.org/10.1182/blood.V130.Suppl_1.243.243

Published: 2017

Journal Articles

CD25 Enables Oncogenic BCR-Signaling and Represents a Therapeutic Target in B Cell Malignancies

Jaewoong Lee, PhD, Huimin Geng, PhD, Zhengshan Chen, MDPhD, Gang Xiao, PhD, Kadriye Nehir Nehir Cosgun, PhD, Francesca Zammarchi, PhD, Patrick Van Berkel, PhD, Ari Melnick, MD, Elisabeth Paietta, PhD, Markus Muschen, MDPhD

Blood (2017) 130 (Supplement 1): 3834.

https://doi.org/10.1182/blood.V130.Suppl_1.3834.3834

Published: 2017

Journal Articles

Lineage Deconvolution Using Chromatin Accessibility and DNA Methylation Shows a Spectrum of Lineage Characteristics and Differentiation States across Acute Leukemias

Jacob L Glass, MDPhD, Alyson J Palia, Francine E. Garrett-Bakelman, MDPhD, Richard Koche, PhD, Ross L. Levine, MD, Martin S. Tallman, MD, Richard James Dillon, MA, PhD MRCP, FRCPath, David Grimwade, Adolfo A. Ferrando, MD PhD, Peter J.M. Valk, PhD, Ruud Delwel, PhD, Maria E. Figueroa, MD, Ari Melnick, MD, Olivier Elemento, PhD

Blood (2017) 130 (Supplement 1): 1208.

https://doi.org/10.1182/blood.V130.Suppl_1.1208.1208

Published: 2017

Journal Articles

SIRT3 Is a Novel Metabolic Driver of and Therapeutic Target for Chemotherapy Resistant Dlbcls

Meng Li, PhD, Ying-Ling Chiang, PhD, Costas Lyssiotis, PhD, Matthew Teater, PhD, Hao Shen, MD, Ling Wang, MS, Jun Young Hong, BS, Hui Jin, PhD, Cihangir Duy, PhD, Sucharita Mistry, PhD, Leandro Cerchietti, MD, Justin Cross, PhD, Lewis Cantley, MD, Hening Lin, PhD, Ari Melnick, MD

Blood (2017) 130 (Supplement 1): 643.

https://doi.org/10.1182/blood.V130.Suppl_1.643.643

Published: 2017

Journal Articles

HSP90 Facilitates Oncogene-Induced Metabolic Reprogramming in B-Cell Lymphomas

Maria Nieves Calvo Vidal, PhD, Jan Krumsiek, PhD, Jayeshkumar Patel, MS, Shao Ning Yang, Jude M Phillip, DPhil, Rossella Marullo, MD PhD, Tony Taldone, PhD, Giorgio Inghirami, MD, Ari Melnick, MD, Gabriela Chiosis, PhD, Leandro Cerchietti, MD

Blood (2017) 130 (Supplement 1): 645.

https://doi.org/10.1182/blood.V130.Suppl_1.645.645

Published: 2017

Journal Articles

m 6 a Regulates Differentiation State and mRNA Translation in Myeloid Leukemia

Ly P Vu, PhD, Brian F Pickering, PhD, Yuanming Cheng, PhD, Zaccara Sara, PhD, Diu Nguyen, PhD, Gerard Minuesa, PhD, Timothy Chou, BS, Arthur Chow, BS, Matthew MacKay, Christopher Famulare, MS, Minal Patel, BA, Francine Garret-Bakelman, MD PhD, Ari Melnick, MD, Martin Carroll, MD, Christopher Mason, PhD, Samie R. Jaffrey, MD PhD, Michael G. Kharas, PhD

Blood (2017) 130 (Supplement 1): 791.

https://doi.org/10.1182/blood.V130.Suppl_1.791.791

Published: 2017

Journal Articles

Genomic Landscapes in Elderly AML

Blood (2017) 130 (Supplement 1): 404.

https://doi.org/10.1182/blood.V130.Suppl_1.404.404

Published: 2017

NARROW

BCL10 Gain-of-Function Mutations Aberrantly Induce Canonical and Non-Canonical NF-Kb Activation and Resistance to Ibrutinib in ABC-DLBCL

Multi-Center Phase II Study of Oral Azacitidine (CC-486) Plus CHOP As Initial Treatment for Peripheral T-Cell Lymphoma (PTCL)

The Tumor Associated Antigen PRAME Exhibits Dualistic Functions That Are Targetable in Diffuse Large B-Cell Lymphoma

Rationale for Targeting BCL6 in MLL-Rearranged B-ALL

Histone 1 Mutations Drive Lymphomagenesis By Inducing Primitive Stem Cell Functions and Epigenetic Instructions through Profound 3D Re-Organization of the B-Cell Genome

An OCT2 / OCA-B / MEF2B Ternary Complex Controls the Activity and Architecture of an Essential Locus Control Region for Normal and Malignant Germinal Center B-Cells

Chemically Induced Degradation of MALT1 to Treat B-Cell Lymphomas

Mapping MALT1 Signaling Connectivity Unveils Novel B-Cell Feedback Mechanisms Directing Assembly of Potent Anti-Lymphoma Regimens

Dynamic Assembly of a Feedback Complex to Regulate Oncogenic B-Cell Receptor-Signaling

Combined EZH2 and BCL2 Inhibitors As Precision Therapy for Genetically Defined DLBCL Subtypes

The Paracaspase MALT1 Acts Independently of Pre-B-Cell Receptor Signaling As a Key Factor in Leukemic Cell Survival in Precursor B-Cell Acute Lymphoblastic Leukemia

EZH2 Gain-of-Function Mutations Generate a Lymphoma-Permissive Immune Niche

Wt1 Haploinsufficiency Induces an Age-Dependent Enhancement in Stem Cell Self-Renewal and Cooperates with FLT3-ITD to Drives Leukemogenesis

Genetically-Defined AML Subgroups Represent Diverse Epigenetic Heterogeneity Landscape

CD25 Enables Oncogenic BCR-Signaling and Represents a Therapeutic Target in B Cell Malignancies

Lineage Deconvolution Using Chromatin Accessibility and DNA Methylation Shows a Spectrum of Lineage Characteristics and Differentiation States across Acute Leukemias

SIRT3 Is a Novel Metabolic Driver of and Therapeutic Target for Chemotherapy Resistant Dlbcls

HSP90 Facilitates Oncogene-Induced Metabolic Reprogramming in B-Cell Lymphomas

m 6 a Regulates Differentiation State and mRNA Translation in Myeloid Leukemia

Genomic Landscapes in Elderly AML

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American Society of Hematology

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ASH Publications

American Society of Hematology

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