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Antonia Lopez-Girona, PhD
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Journal Articles

Degradation of Aiolos and Ikaros Followed By Downregulation of c-Myc and then IRF4 Leads to Programmed Cell Death in Myeloma Cells Sensitive to IMiDs ® Immunomodulatory Compounds

Chad C Bjorklund, PhD, Courtney G. Havens, PhD, Patrick R Hagner, PhD, Anita K. Gandhi, PhD, Maria Wang, PhD, Michael D Amatangelo, PhD, Ling Lu, BS, Huisheng Wang, MS, Mike Breider, DVM, PhD DACVP, Yan Ren, MS, Antonia Lopez-Girona, PhD, Anjan Thakurta, PhD, Anke Klippel, PhD, Rajesh Chopra, MD PhD
Journal: Blood
Blood (2014) 124 (21): 4700.
https://doi.org/10.1182/blood.V124.21.4700.4700
Published: 2014
Journal Articles

IMiDs® Immunomodulatory Agents Regulate Interferon-Stimulated Genes through Cereblon-Mediated Aiolos Destruction in Multiple Myeloma (MM) Cells: Identification of a Novel Mechanism of Action and Pathway for Resistance

Courtney G. Havens, PhD, Chad Bjorklund, PhD, Jian Kang, BS, Maria Ortiz, PhD, Celia Fontanillo, PhD, Michael Amatangelo, PhD, Ling Lu, BS, Paola E. Neri, MD PhD, Antonia Lopez-Girona, PhD, Nizar J. Bahlis, MD, Anjan Thakurta, PhD, Mathew Trotter, MD, Anita K. Gandhi, PhD, Anke Klippel, PhD, Rajesh Chopra, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3432.
https://doi.org/10.1182/blood.V124.21.3432.3432
Published: 2014
Journal Articles

Dual-Color CRBN/CD138 Immunohistochemistry Assay for Measuring Cereblon Protein in Samples from Patients with Multiple Myeloma

Yan Ren, MS, Maria Wang, PhD, Suzanne Couta, DVM, PhD DACVP, Donna Hansel, MD, Karen Miller, BS, Antonia Lopez-Girona, PhD, Chad C Bjorklund, PhD, Anita K. Gandhi, PhD, Anjan Thakurta, PhD, Rajesh Chopra, MD PhD, Michael Breider, DVM, PhD DACVP
Journal: Blood
Blood (2014) 124 (21): 6021.
https://doi.org/10.1182/blood.V124.21.6021.6021
Published: 2014
Journal Articles

Absence Of Mutation In Cereblon (CRBN) and DNA Damage Binding Protein 1 (DDB1) Genes In Myeloma Cells and Patients and Its Clinical Significance

Anjan Thakurta, PhD, Anita K Gandhi, PhD, Michelle Waldman, MS, Chad C. Bjorklund, Ph.D., Suzanne Lentzsch, MD, PhD, Stephen A Schey, MD, Yolanda Calle, PhD, Rajani Chelliah, BSc, MSc, Robert Z. Orlowski, M.D., Ph.D, Anup Madan, PhD, Yuhong Ning, Derek Mendy, B.S., Antonia Lopez-Girona, PhD, Peter H Schafer, PhD, Herve Avet-Loiseau, MD, Rajesh Chopra, MD
Journal: Blood
Blood (2013) 122 (21): 3139.
https://doi.org/10.1182/blood.V122.21.3139.3139
Published: 2013
Journal Articles

CC-122 Is a Novel Pleiotropic Pathway Modifier with Potent in Vitro Immunomodulatory and Anti-Angiogenic Properties and in Vivo Anti-Tumor Activity in Hematological Cancers.

Anita K Gandhi, PhD, Derek Mendy, BS, Anastasia Parton, BA, Lei Wu, MS, ECFMG, Jolanta Kosek, BA, Ling-Hua Zhang, PhD, Lori Capone, BS, Antonia Lopez-Girona, PhD, Peter H Schafer, PhD, Rajesh Chopra, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2963.
https://doi.org/10.1182/blood.V120.21.2963.2963
Published: 2012
Journal Articles

GSK-3 Spatial Regulation Has an Essential Role in Lenalidomide Activity and Represents a Biomarker of Clinical Response in CLL

Suzanne Trudel, MD, Sam Scanga, PhD, Fabrizio G Mastronardi, PhD, Ellen Nong Wei, MSc, Frank Mercurio, PhD, Antonia Lopez-Girona, PhD, Svetlana Gaidarova, MS, David R. Webb, PhD, Christine Chen, MD, Keith Stewart, MBA, MB, CHB, Armen S Manoukian, PhD
Journal: Blood
Blood (2012) 120 (21): 1793.
https://doi.org/10.1182/blood.V120.21.1793.1793
Published: 2012
Journal Articles

Targeting Cereblon with the High Affinity Immunomodulatory Compound CC-220: A Novel Therapeutic Agent for B Cell Dyscrasias

Peter H Schafer, PhD, Emily Rychak, PhD, Derek Mendy, BS, Anastasia Parton, BA, Lori Capone, BS, Antonia Lopez-Girona, PhD, Jilly F Evans, PhD, Tom O Daniel, MD, PhD, Rajesh Chopra, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 1055.
https://doi.org/10.1182/blood.V120.21.1055.1055
Published: 2012
Journal Articles

Detection and Quantification of Cereblon Protein and mRNA in Multiple Myeloma Cell Lines and Primary CD138 + multiple Myeloma Cells

Anita K Gandhi, PhD, Herve Avet-Loiseau, MD, Michelle Waldman, MS, Anjan Thakurta, PhD, Sharon L Aukerman, PhD, Gengxin Chen, PhD, Derek Mendy, BS, Emily Rychak, PhD, Karen Miller, Svetlana Gaidarova, MS, Michael Gonzales, Brian Cathers, PhD, Peter H Schafer, PhD, Tom O Daniel, MD, PhD, Antonia Lopez-Girona, PhD, Rajesh Chopra, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 4043.
https://doi.org/10.1182/blood.V120.21.4043.4043
Published: 2012
Journal Articles

Targeting the p27 Kip1 E3 Ubiquitin Ligase for the Treatment of Multiple Myeloma and Other Hematological Malignancies.

Qing Chen, PhD, Weilin Xie, PhD, Deborah J. Kuhn, PhD, Peter M. Voorhees, MD, Derek Mendy, MD, Antonia Lopez-Girona, PhD, Veronique Plantevin, PhD, Weiming Xu, PhD, Laura De Parseval, PhD, Laura G. Corral, PhD, Emilia Glezer, PhD, Kyle Chan, PhD, Frank Mercurio, PhD, Robert Z. Orlowski, MD, PhD
Journal: Blood
Blood (2006) 108 (11): 372.
https://doi.org/10.1182/blood.V108.11.372.372
Published: 2006