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Andrea van Elsas, PhD
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Journal Articles

Bion-1301 Blocks APRIL-Induced Anti-Apoptotic Signaling, Immune Suppressive Phenotype, and Chemokine Production Associated with Multiple Myeloma

Jeroen Bakker, Maurice Habraken, John Dulos, PhD, Yu-Tzu Tai, PhD, Andrea Van Elsas, PhD, Paul Vink, Hans Eenennaam, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1908.
https://doi.org/10.1182/blood-2018-99-117726
Published: 2018
Journal Articles

APRIL Is Significantly Elevated at All Stages of Multiple Myeloma (MM) and Interferes with Anti-Bcma Monoclonal Antibody-Mediated Cytolysis, Supporting the Clinical Evaluation of Bion-1301 As a Novel Therapeutic Approach in MM

Yu-Tzu Tai, PhD, John Dulos, PhD, Lars Guelen, Liang Lin, PhD, Lijie Xing, MD, Shih-Feng Cho, MD PhD, Kenneth Wen, BS, Tengteng Yu, MD, Phillip A Hsieh, Peter van Zandvoort, Bsc, Guido van de Wiel, Jos van de Crommert, Bsc, Bonny Lejeune, Hamid Namini, Hans Eenennaam, PhD, Andrea van Elsas, PhD, Paul Richardson, Nikhil Munshi, MD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3209.
https://doi.org/10.1182/blood-2018-99-117296
Published: 2018
Journal Articles

A First in Class APRIL Fully Blocking Antibody Targets Novel Immune Regulation of APRIL in Multiple Myeloma: Further Therapeutic Implication

Liang Lin, PhD, Lijie Xing, MD, Chirag M Acharya, MBBS, Kenneth Wen, BS, Phillip Hsieh, John Dulos, PhD, Andrea Van Elsas, PhD, Nikhil Munshi, MD, Paul G Richardson, MD, Kenneth C Anderson, MD, Yu-Tzu Tai, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 499.
https://doi.org/10.1182/blood.V130.Suppl_1.499.499
Published: 2017
Journal Articles

Bion-1301, a First-in-Class APRIL Neutralizing Antibody for the Treatment of Multiple Myeloma: Preclinical Safety, and Analysis of Pharmacokinetics — Pharmacodynamics Relationship

John Dulos, PhD, Lilian Driessen, Bsc, Peter van Zandvoort, Bsc, Jos van de Crommert, Bsc, Justin Skoble, PhD, Nitya Nair, Msc, Britta Randlev, Bsc, Eduard de Cock, Msc, Jeroen Elassaiss Schaap, PhD, Hans Eenennaam, PhD, Andrea van Elsas, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1827.
https://doi.org/10.1182/blood.V130.Suppl_1.1827.1827
Published: 2017
Journal Articles

APRIL/B Cell Maturation Antigen (BCMA) Signaling Cascades Promote Human Multiple Myeloma Growth and Mediate Immunosuppression in the Bone Marrow Microenvironment Via IL-10, TGF-b, and PD-L1

Yu-Tzu Tai, PhD, Chirag Acharya, MD, Gang An, MDPhD, Michele Moschetta, MD, Mike Zhong, BS, Xiaoyan Feng, MD, Hans van Eenennaam, PhD, Andrea van Elsas, PhD, Lugui Qiu, MD PhD, Nikhil C. Munshi, MD, Kenneth C Anderson, MD
Journal: Blood
Blood (2015) 126 (23): 1810.
https://doi.org/10.1182/blood.V126.23.1810.1810
Published: 2015
Journal Articles

A Novel Anti-a Proliferation-Inducing Ligand Hapril.01A Monoclonal Antibody Targets Multiple Myeloma Cells in the Bone Marrow Microenvironment

Yu-Tzu Tai, PhD, Chirag Acharya, MD, Gang An, MD PhD, Mike Y Zhong, Michele Cea, MD, Antonia Cagnetta, MD, Hua Jiang, MDPhD, Hans van Eenennaam, PhD, Andrea van Elsas, PhD, Nikhil C. Munshi, MD, Kenneth C. Anderson
Journal: Blood
Blood (2014) 124 (21): 2098.
https://doi.org/10.1182/blood.V124.21.2098.2098
Published: 2014