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Alexander Murison, PhD
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Journal Articles

Histone Demethylase Inhibition As a Novel Therapeutic Strategy in Myeloma

Charlotte Pawlyn, MBBChir, Edward Hookway, MBBChir, Peter Cain, PhD, Laurynas Pliuskys, BSc, Martin F Kaiser, MD, Michael Bright, PhD, Lauren I Aronson, BSc(Hons), Alexander Murison, PhD, Morten Lindow, PhD, Susanna Obad, PhD, Henrik Oerum, PhD, Udo Opperman, PhD, Gareth J. Morgan, MD PhD, Faith E Davies, MD
Journal: Blood
Blood (2014) 124 (21): 2087.
https://doi.org/10.1182/blood.V124.21.2087.2087
Published: 2014
Journal Articles

High Resolution Genome Wide DNA Methylation Analysis in a Large Trial Group Reveals a Novel Epigenetically Defined Subgroup of Myeloma Patients Characterized By Developmental Gene Hypermethylation

Martin F Kaiser, MD, Alexander Murison, PhD, Charlotte Pawlyn, MBBChir, Eileen M Boyle, MD, David C Johnson, PhD, Brian A Walker, PhD, Ping Wu, MBBS, MSc, Dil Begum, BSc, Nasrin Dahir, BSc, Christopher P Wardell, PhD, Paula Proszek, MSc, David A Cairns, PhD, Walter Gregory, PhD, Graham Jackson, MD, Roger G Owen, MD, Gordon Cook, MD PhD, Mark T Drayson, MDPhD, Faith E Davies, MD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2014) 124 (21): 2189.
https://doi.org/10.1182/blood.V124.21.2189.2189
Published: 2014
Journal Articles

The Spectrum of Epigenetic Mutations in Myeloma and Their Clinical Impact

Charlotte Pawlyn, MBBChir, Martin F Kaiser, MD, Brian A Walker, PhD, Christopher P Wardell, PhD, Alexander Murison, PhD, David C Johnson, PhD, Lorenzo Melchor, PhD, Eileen M Boyle, MD, John Jones, MD, Dil Begum, BSc, Nasrin Dahir, BSc, Paula Proszek, MSc, David A Cairns, PhD, Walter Gregory, PhD, Gordon Cook, MD, Roger G Owen, MD, Mark T Drayson, MDPhD, Graham Jackson, MD, Faith E Davies, MD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2014) 124 (21): 2194.
https://doi.org/10.1182/blood.V124.21.2194.2194
Published: 2014
Journal Articles

Somatic Mutation Spectrum in Monoclonal Gammopathy of Undetermined Significance Compared to Multiple Myeloma

Aneta Mikulasova, MSc, Brian A Walker, PhD, Christopher P Wardell, PhD, Eileen M Boyle, MD, Alexander Murison, PhD, Zuzana Kufova, MSc, Ludek Pour, Doc, MD PhD, Petr Kuglik, AssocProf, CSc, Roman Hajek, Prof, MD PhD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3346.
https://doi.org/10.1182/blood.V124.21.3346.3346
Published: 2014
Journal Articles

Apobec Family Mutational Signatures Are Associated with Poor Prognosis Translocations in Multiple Myeloma

Brian A Walker, PhD, Christopher P Wardell, PhD, Alexander Murison, PhD, Eileen M Boyle, MD, Lorenzo Melchor, PhD, Charlotte Pawlyn, MD, Martin F Kaiser, MD, Dil Begum, BSc, Nasrin Dahir, BSc, Paula Proszek, MSc, David C Johnson, PhD, Ya-Wei Qiang, MD PhD, John Jones, MD, David A Cairns, PhD, Walter Gregory, PhD, Roger G Owen, MD, Gordon Cook, MD, Mark T Drayson, MDPhD, Graham Jackson, MD, Faith E Davies, MD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2014) 124 (21): 723.
https://doi.org/10.1182/blood.V124.21.723.723
Published: 2014
Journal Articles

Exome Sequencing to Define a Genetic Signature of Plasma Cells in Systemic AL Amyloidosis

Eileen M Boyle, MD, Brian A Walker, PhD, Dorota Rowczienio, MSc, Christopher P Wardell, PhD, Alexander Murison, PhD, Aneta Mikulasova, M.Sc., Sajitha Sachchithanantham, BSc,MBBS,MRCP,FRCPath,, Anna Baginska, Shameem Mahmood, MRCP. FRCPath, Julian D Gillmore, Helen J Lachmann, MD FRCP, Philip N Hawkins, MD FRCP, FMedSci, Xavier Leleu, MD PhD, Faith E Davies, MD, Gareth J. Morgan, MD PhD, Ashutosh Wechalekar, MDFRCPath
Journal: Blood
Blood (2014) 124 (21): 726.
https://doi.org/10.1182/blood.V124.21.726.726
Published: 2014
Journal Articles

Mutational Patterns and Copy Number Changes at Diagnosis Are a Powerful Tool to Predict Outcome: Result of the Sequencing Study of 463 Newly Diagnosed Myeloma Trial Patients

Eileen M Boyle, MD, Brian A Walker, PhD, Christopher P Wardell, PhD, Alexander Murison, PhD, Lorenzo Melchor, PhD, Martin F Kaiser, MD, Dil Begum, BSc, Paula Proszek, MSc, Nasrin Dahir, BSc, David C Johnson, PhD, Charlotte Pawlyn, MBBChir, John Jones, MD, Fabio Mirabella, PhD, Annamaria Brioli, Aneta Mikulasova, M.Sc., David A Cairns, PhD, Walter Gregory, PhD, Ana Quartilho, PhD, Mark T Drayson, MDPhD, Nigel Russell, Gordon Cook, MD PhD, Graham H Jackson, MD PhD, Faith E Davies, MD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2014) 124 (21): 637.
https://doi.org/10.1182/blood.V124.21.637.637
Published: 2014
Journal Articles

The Extent of Intra-Clonal Genetic Diversity within the Myeloma Clone Is a Predictive Biomarker of Progression and Outcome after Treatment

Lorenzo Melchor, PhD, Alexander Murison, PhD, Eileen M Boyle, MD, Christopher P Wardell, PhD, John Jones, MD, Martin F Kaiser, MD, Charlotte Pawlyn, MBBChir, David C Johnson, PhD, Dil Begum, BSc, Paula Proszek, MSc, Nasrin Dahir, BSc, David A Cairns, PhD, Walter Gregory, PhD, Roger G Owen, MD, Gordon Cook, MD PhD, Mark T Drayson, MDPhD, Graham H Jackson, MD PhD, Faith E Davies, MD, Brian A Walker, PhD, Gareth J. Morgan, MD PhD
Journal: Blood
Blood (2014) 124 (21): 640.
https://doi.org/10.1182/blood.V124.21.640.640
Published: 2014
Journal Articles

Expression Quantitative Trait Loci Reveal Regulatory Regions Important In The Pathogenesis of Multiple Myeloma

David C Johnson, PhD, Niels Weinhold, PhD, Tobias Meissner, Dipl.-bioinf. (FH), Brian A Walker, PhD, Peter Broderick, PhD, Bowang Chen, PhD, Daniel Chubb, PhD, Per Hoffmann, PhD, Christopher P Wardell, PhD, Alexander Murison, PhD, Ni L Li, BSc, Fiona M Ross, DPhil, Jérôme Moreaux, PhD, Asta Försti, PhD, Walter Gregory, PhD, Faith E Davies, MD, Richard S Houlston, MD, PhD, Kari Hemminki, PhD, Bernard Klein, PhD, Dirk Hose, Dr. med. dipl.-phys., Hartmut Goldschmidt, MD, Gareth J Morgan, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1847.
https://doi.org/10.1182/blood.V122.21.1847.1847
Published: 2013
Journal Articles

Discovery Of Genome Wide Epigenetic Programming In t(4;14) Multiple Myeloma and In The Progression From Myeloma To Plasma Cell Leukemia Via Methyl Binding Domain Protein Capture and Sequencing

Martin F Kaiser, MD, Alexander Murison, PhD, Christopher P Wardell, PhD, David C Johnson, PhD, Charlotte Pawlyn, MD, Fabio Mirabella, PhD, Lorenzo Melchor, PhD, Kerry Fenwick, Iwanka Kozarewa, PhD, Faith E Davies, MD, Brian A Walker, PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2013) 122 (21): 599.
https://doi.org/10.1182/blood.V122.21.599.599
Published: 2013
Journal Articles

Single-Cell Genetic Analysis Reveals The Genetic Composition Of Founder Clones, Phylogenetic Patterns Of Branching and Parallel Evolution, and Clonal Fluctuations Following Patient Treatment In Multiple Myeloma

Lorenzo Melchor, PhD, Annamaria Brioli, MD, Christopher P Wardell, PhD, Alexander Murison, PhD, Nicola E Potter, PhD, Martin F Kaiser, MD, Rosemary A Fryer, PhD, David C Johnson, PhD, Dil Begum, BSc, Sanna Hulkki, Gowri Vijayaraghavan, Ian Titley, PhD, Michele Cavo, MD, Faith E Davies, MD, Brian A Walker, PhD, Gareth J Morgan, MD PhD
Journal: Blood
Blood (2013) 122 (21): 398.
https://doi.org/10.1182/blood.V122.21.398.398
Published: 2013