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Journal Articles

Cathecholamines Differently Regulate Human AML and Normal Hematopoietic Progenitor Cell Motility Via miR126 and RGS16

Abraham Avigdor, MD, Chiara Medaglia, PhD, Alexander Kalinkovich, MD, PhD, Tomer Itkin, PhD, Menachem Bitan, MD, PhD, Arnon Nagler, MD, MHA, Tsvee Lapidot, PhD

Blood (2013) 122 (21): 1413.

https://doi.org/10.1182/blood.V122.21.1413.1413

Published: 2013

Journal Articles

EPCR Limits Nitric Oxide Levels, Mediating Human and Murine Stem Cell Adhesion and Retention In The Bone Marrow, By Conjugating PAR1 and CXCR4 Signaling

Shiri Gur Cohen, MSc, Tomer Itkin, PhD, Aya Ludin, DMD, PhD, Sagarika Chakrabarty, PhD, Orit Kollet, PhD, Karin Golan, MSc, Alexander Kalinkovich, MD, PhD, Eitan Wong, PhD, Ayelet Erez, MD PhD, Irit Sagi, PhD, Charles T Esmon, PhD, Wolfram Ruf, MD, Tsvee Lapidot, PhD

Blood (2013) 122 (21): 795.

https://doi.org/10.1182/blood.V122.21.795.795

Published: 2013

Journal Articles

Human and Murine β-Defensin-Derived Peptides Induce Rapid Mobilization Of Murine Hematopoietic Stem and Progenitor Cells Via Activation Of CXCR4 Signaling and CXCL12 Release

Amir Schajnovitz, PhD, Alexander Kalinkovich, MD, PhD, Kfir Lapid, PhD, Alexander Berchanski, PhD, Tomer Itkin, PhD, Aya Ludin, DMD, PhD, Shiri Gur-Cohen, MSc, Karin Golan, MSc, Borja Saez, PhD, Orit Kollet, PhD, Kerstin Ahrens, PhD, Ehrahrdt Proksch, MD, PhD, Aviva Lapidot, PhD, Matityahu Fridkin, PhD, David T. Scadden, MD, Tsvee Lapidot, PhD

Blood (2013) 122 (21): 890.

https://doi.org/10.1182/blood.V122.21.890.890

Published: 2013

Journal Articles

Regulation Of Hematopoietic Stem Cell Trafficking By The Coagulation Pathway

Shiri Gur Cohen, MSc, Tomer Itkin, PhD, Orit Kollet, PhD, Sagarika Chakrabarty, PhD, Aya Ludin, DMD, PhD, Karin Golan, MSc, Alexander Kalinkovich, MD, PhD, Xin-Jiang Lu, PhD, Jeff R. Crosby, PhD, Brett P. Monia, PhD, Charles T Esmon, PhD, Wolfram Ruf, MD, Tsvee Lapidot, PhD

Blood (2013) 122 (21): 456.

https://doi.org/10.1182/blood.V122.21.456.456

Published: 2013

Journal Articles

Hematopoietic Stem Cells and Their BM Stromal Microenvironment Share a Dynamic Inverse Metabolic State During Quiescence and Proliferation Via ROS Transfer Between The Two Populations

Karin Golan, MSc, Aya Ludin, DMD, PhD, Tomer Itkin, PhD, Shiri Cohen-Gur, MSc, Orit Kollet, PhD, Xin-Jiang Lu, PhD, Alexander Kalinkovich, MD, PhD, Maria Maryanovich, PhD, Atan Gross, PhD, Tsvee Lapidot, PhD

Blood (2013) 122 (21): 587.

https://doi.org/10.1182/blood.V122.21.587.587

Published: 2013

Journal Articles

Blood Cell Replenishment and Bone Marrow Stem Cell Pool Renewal Are Regulated By Different Circadian Peaks Via Norepinephrine and TNFα/S1P Signaling

Karin Golan, MSc, Aya Ludin, DMD, PhD, Tomer Itkin, PhD, Shiri Cohen-Gur, MSc, Orit Kollet, PhD, Xin-Jiang Lu, PhD, Alexander Kalinkovich, MD, PhD, Tsvee Lapidot, PhD

Blood (2013) 122 (21): 217.

https://doi.org/10.1182/blood.V122.21.217.217

Published: 2013

Journal Articles

Endothelial Blood-Bone Marrow-Barrier Dynamically Regulates Balanced Stem and Progenitor Cell Trafficking and Maintenance

Tomer Itkin, MSc, Shiri Gur-Cohen, MSc, Aya Ludin, DMD, PhD, Alexander Kalinkovich, MD, PhD, Karin Golan, MSc, Giulia Caglio, MSc, David M. Ornitz, MD, PhD, Ralf H. Adams, PhD, Orit Kollet, PhD, Tsvee Lapidot, PhD

Blood (2012) 120 (21): 507.

https://doi.org/10.1182/blood.V120.21.507.507

Published: 2012

Journal Articles

Coagulation Factor Thrombin Regulates Hematopoietic Stem and Progenitor Cell Egress and Mobilization Via PAR-1 & CXCR4 Upregulation, SDF-1 Secretion and EPCR Shedding

Shiri Gur-Cohen, M.Sc, Tomer Itkin, PhD, Aya Ludin, DMD, Ph.D, Orit Kollet, PhD, Karin Golan, MSc, Alexander Kalinkovich, MD, PhD, Elias Shezen, PhD, Tsvee Lapidot, PhD

Blood (2011) 118 (21): 2341.

https://doi.org/10.1182/blood.V118.21.2341.2341

Published: 2011

Journal Articles

GSK3β Signaling Regulates the Motility of Hematopoietic Progenitors Via Prune.

Kfir Lapid, MSc, Gabriele D‘Uva, MSc, Alexander Kalinkovich, MD, PhD, Aya Ludin, DMD, MSc, Karin Golan, MSc, Tomer Itkin, MSc, Massimo Zollo, PhD, Tsvee Lapidot, PhD

Blood (2010) 116 (21): 1553.

https://doi.org/10.1182/blood.V116.21.1553.1553

Published: 2010

Journal Articles

The Chemotactic Lipid S1P Regulates Hematopoietic Progenitor Cell Egress and Mobilization Via Its Major Receptor S1P 1 and by SDF-1 Inhibition In a p38/Akt/mTOR Dependent Manner

Karin Golan, MSc, Yaron Vagima, PhD, Aya Ludin, DMD, MSc, Tomer Itkin, PhD, Alexander Kalinkovich, MD, PhD, Shiri Cohen-Gur, MSc, Orit Kollet, PhD, Amir Schajnovitz, MSc, Shoham Shivtiel, PhD, Tsvee Lapidot, PhD

Blood (2010) 116 (21): 553.

https://doi.org/10.1182/blood.V116.21.553.553

Published: 2010

Journal Articles

Circadian Corticosterone Levels Regulate and Integrate Hematopoietic Stem and Progenitor Cell Function and Bone Remodeling Via Notch1 Signaling

Orit Kollet, PhD, Yaron Vagima, PhD, Karin Golan, MSc, Jonathan Canaani, MD, Gabriele D'Uva, MSc, Tomer Itkin, MSc, Alexander Kalinkovich, MD, PhD, Elias Shezen, PhD, Adi Neufeld-Cohen, MSc, Diana Rashkovan, MSc, Alon Chen, PhD, Tsvee Lapidot, PhD

Blood (2010) 116 (21): 840.

https://doi.org/10.1182/blood.V116.21.840.840

Published: 2010

Journal Articles

Expansion of Normal and Leukemic Hematopoietic Progenitor Cells by PTH Requires bFGF Activation of c-Kit and Its Downstream JAK2/STAT5 Signaling.

Tomer Itkin, MSc, Aya Ludin, DMD, MSc, Amir Schajnovitz, MSc, Alexander Kalinkovich, MD, PhD, Orit Kollet, PhD, Douglas J Coffin, PhD, Thorsten Berg, PhD, Wanda Piacibello, MD, Tsvee Lapidot, PhD

Blood (2009) 114 (22): 2511.

https://doi.org/10.1182/blood.V114.22.2511.2511

Published: 2009

Journal Articles

Functional SDF-1 Secretion from BM Stromal Cells Is a Cell Contact-Dependent Event Mediated by Cx43 and Cx45 Gap-Junctions

Amir Schajnovitz, MSc, Tomer Itkin, MSc, Aya Ludin, DMD, MSc, Alexander Kalinkovich, MD, PhD, Kfir Lapid, MSc, Rony Seger, PhD, Tsvee Lapidot, PhD

Blood (2008) 112 (11): 319.

https://doi.org/10.1182/blood.V112.11.319.319

Published: 2008

Journal Articles

In Vivo Mobilization of Leukemic Human Precursor-B-ALL Cells by the CXCR4-Antagonist AMD3100 Is Via Secretion of SDF-1 and Synergistically by Catecholamine Action.

Eike C. Buss, MD, Alexander Kalinkovich, MD, PhD, Amir Schajnovitz, MSc, Orit Kollet, PhD, Ayelet Dar, PhD, Melania Tesio, PhD, Stefan Fruehauf, MD, Marc Hotfilder, PhD, Anthony D. Ho, MD, Leonard D. Shultz, Tsvee Lapidot, PhD

Blood (2008) 112 (11): 1920.

https://doi.org/10.1182/blood.V112.11.1920.1920

Published: 2008

Journal Articles

The Tyrosine Kinase c-Met Is Selectively Expressed on Motile Hematopoietic Progenitors Following G-CSF Administration and Promotes Mobilization by Regulating Stem Cell Niche Components.

Melania Tesio, MSc, Alexander Kalinkovich, MD, PhD, Amir Schajnovitz, Msc, Ayelet Dar, PhD, Orit Kollet, PhD, Polinna Goichberg, PhD, Isabelle Petit, PhD, Silvia Giordano, MD,PhD, Massimo Aglietta, MD, Wanda Piacibello, MD, Tsvee Lapidot, PhD

Blood (2006) 108 (11): 3376.

https://doi.org/10.1182/blood.V108.11.3376.3376

Published: 2006

Journal Articles

Functional CXCR4 Expressing Microparticles and SDF-1 Correlate with Circulating AML Cell Counts.

Alexander Kalinkovich, MD, PhD, Sigal Tavor, MD, Abraham Avigdor, MD, Joy Kahn, PhD, Alexander Brill, PhD, Isabelle Petit, PhD, Polina Goichberg, PhD, Melania Tesio, M.Sc, Neta Netzer, Ms, Elizabeth Naparstek, Izhar Hardan, MD, Arnon Nagler, Igor Resnick, MD, Alexander Tsimanis, PhD, Tsvee Lapidot

Blood (2006) 108 (11): 4375.

https://doi.org/10.1182/blood.V108.11.4375.4375

Published: 2006

Journal Articles

CD45 Phosphatase Is Involved in Motility and Development of Hematopoietic Stem and Maturing Cells by the Regulation of Cell Adhesion and Cytokine Signaling.

Shoham Shivtiel, PhD, Isabelle Petit, PhD, Abraham Avigdor, MD, Polina Goichberg, PhD, Sarit Samira, PhD, Alexander Kalinkovich, MD, Orit Kollet, PhD, Arnon Nagler, MD, Tsvee Lapidot, PhD

Blood (2004) 104 (11): 119.

https://doi.org/10.1182/blood.V104.11.119.119

Published: 2004

NARROW

Cathecholamines Differently Regulate Human AML and Normal Hematopoietic Progenitor Cell Motility Via miR126 and RGS16

EPCR Limits Nitric Oxide Levels, Mediating Human and Murine Stem Cell Adhesion and Retention In The Bone Marrow, By Conjugating PAR1 and CXCR4 Signaling

Human and Murine β-Defensin-Derived Peptides Induce Rapid Mobilization Of Murine Hematopoietic Stem and Progenitor Cells Via Activation Of CXCR4 Signaling and CXCL12 Release

Regulation Of Hematopoietic Stem Cell Trafficking By The Coagulation Pathway

Hematopoietic Stem Cells and Their BM Stromal Microenvironment Share a Dynamic Inverse Metabolic State During Quiescence and Proliferation Via ROS Transfer Between The Two Populations

Blood Cell Replenishment and Bone Marrow Stem Cell Pool Renewal Are Regulated By Different Circadian Peaks Via Norepinephrine and TNFα/S1P Signaling

Endothelial Blood-Bone Marrow-Barrier Dynamically Regulates Balanced Stem and Progenitor Cell Trafficking and Maintenance

Coagulation Factor Thrombin Regulates Hematopoietic Stem and Progenitor Cell Egress and Mobilization Via PAR-1 & CXCR4 Upregulation, SDF-1 Secretion and EPCR Shedding

GSK3β Signaling Regulates the Motility of Hematopoietic Progenitors Via Prune.

The Chemotactic Lipid S1P Regulates Hematopoietic Progenitor Cell Egress and Mobilization Via Its Major Receptor S1P 1 and by SDF-1 Inhibition In a p38/Akt/mTOR Dependent Manner

Circadian Corticosterone Levels Regulate and Integrate Hematopoietic Stem and Progenitor Cell Function and Bone Remodeling Via Notch1 Signaling

Expansion of Normal and Leukemic Hematopoietic Progenitor Cells by PTH Requires bFGF Activation of c-Kit and Its Downstream JAK2/STAT5 Signaling.

Functional SDF-1 Secretion from BM Stromal Cells Is a Cell Contact-Dependent Event Mediated by Cx43 and Cx45 Gap-Junctions

In Vivo Mobilization of Leukemic Human Precursor-B-ALL Cells by the CXCR4-Antagonist AMD3100 Is Via Secretion of SDF-1 and Synergistically by Catecholamine Action.

The Tyrosine Kinase c-Met Is Selectively Expressed on Motile Hematopoietic Progenitors Following G-CSF Administration and Promotes Mobilization by Regulating Stem Cell Niche Components.

Functional CXCR4 Expressing Microparticles and SDF-1 Correlate with Circulating AML Cell Counts.

CD45 Phosphatase Is Involved in Motility and Development of Hematopoietic Stem and Maturing Cells by the Regulation of Cell Adhesion and Cytokine Signaling.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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