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Alexander Astrakhan, PhD
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Journal Articles

Knockout of CBLB Greatly Enhances Anti-Tumor Activity of CAR T Cells

Kathryn Hooper, PhD, Kyle Havens, PhD, Anne-Rachel Krostag, BS, Michael S Magee, PhD, Unja Martin, Ankit Gupta, PhD, Yegor Smurnyy, PhD, Lisa Pechilis, Amanda Rode, Andrew Chavkin, MS, Shannon Grande, PhD, Richard A. Morgan, PhD, Jordan Jarjour, PhD, Alexander Astrakhan, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 338.
https://doi.org/10.1182/blood-2018-99-119247
Published: 2018
Journal Articles

Gene Editing of TRAC Locus Utilizing Megatal Nucleases Increases Expression of Transgenic TCRs Delivered Via Lentiviral Vector-Mediated Gene Transfer

Michael S Magee, PhD, Iulia Diaconu, PhD, Mark Pogson, PhD, Ankit Gupta, PhD, Amy Jensen-Smith, PhD, Brian Collette, BS, Andrew Chavkin, MS, Eli Pasackow, BS, Aaron Edwards, MS, Kevin M. Friedman, Alexander Astrakhan, PhD, Michael T Certo, PhD, Jordan Jarjour, PhD, Richard A. Morgan, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1906.
https://doi.org/10.1182/blood.V130.Suppl_1.1906.1906
Published: 2017
Journal Articles

A Drug-Regulated CAR Platform (DARIC) Induces Effective and Reversible Tumor Control In Vivo Using Non-Immunosuppressive Rapamycin Dosing

Wai-Hang Leung, PhD, Michael T Certo, PhD, Holly M. Horton, PhD, Joel Gay, Tracy VandenBerg, Jordan Jarjour, PhD, Alexander Astrakhan, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1910.
https://doi.org/10.1182/blood.V130.Suppl_1.1910.1910
Published: 2017
Journal Articles

Megatal, Crispr/Cas9, and Talen T-Cell Receptor Gene Editing

Mark J. Osborn, PhD, Beau R Webber, PhD, Friederike Knipping, Cara-lin Lonetree, Anthony DeFeo, Amber McElroy, Colby Starker, PhD, Richard Gabriel, Sarah Merkel, Keli L. Hippen, PhD, Daniel Voytas, PhD, Christof von Kalle, MD, Manfred Schmidt, PhD, Jeffrey S. Miller, MD, Jordan Jarjour, PhD, Alexander Astrakhan, PhD, Andrew M Scharenberg, MD, Jakub Tolar, MD, PhD, Bruce R. Blazar, MD
Journal: Blood
Blood (2015) 126 (23): 2045.
https://doi.org/10.1182/blood.V126.23.2045.2045
Published: 2015