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Journal Articles

Comprehensive Genetic Analysis Revealed Myeloid/Natural Killer (NK) Cell Precursor Acute Leukemia As a Novel Distinctive Leukemia Entity

Akira Nishimura, MD, Kazuaki Yokoyama, MD PhD, Chika Yamagishi, MD, Toshihiko Imamura, MD PhD, Takuya Naruto, MD PhD, Tomohiro Morio, MD PhD, Yukie Tanaka, PhD, Akinori Kanai, PhD, Hirotaka Matsui, MD PhD, Naoko Higuchi, MD, Akiko Takada, MD, Haruna Okuno, MD, Shoji Saito, MD PhD, Shuhei Karakawa, MD PhD, Shogo Kobayashi, MD, Daisuke Hasegawa, MD PhD, Hiroyuki Fujisaki, MD PhD, Daiichiro Hasegawa, MD PhD, Kazutoshi Koike, MD PhD, Takashi Koike, MD, Shinya Rai, MD PhD, Katsutsugu Umeda, MD PhD, Hideki Sano, MD, Yujin Sekinaka, MD PhD, Atsushi Ogawa, MD PhD, Akitoshi Kinoshita, MD PhD, Norio Shiba, MD PhD, Mizuka Miki, MD, Fumihiko Kimura, MD PhD, Hideki Nakayama, MD, Yozo Nakazawa, MD PhD, Takashi Taga, MD PhD, Tomohiko Taki, MD PhD, Souichi Adachi, MD PhD, Atsushi Manabe, MD PhD, Katsuyoshi Koh, MD, Yasushi Ishida, MD PhD, Arinobu Tojo, MD PhD, Masatoshi Takagi, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 14–15.
https://doi.org/10.1182/blood-2020-139312
Published: 2020
Journal Articles

NUDT15 Variants Confer High Incidence of Secondary Malignancies of ALL in Children

Masanori Yoshida, MD, Kazuhiko Nakabayashi, PhD, Aiko Sato-Otsubo, PhD, Shinichi Tsujimoto, MD PhD, Kaoru Yoshida, MD, Ryota Shirai, MD, Tomoo Osumi, MD, Yuki Yuza, MD PhD, Masatoshi Takagi, MD PhD, Hiroyuki Takahashi, MD PhD, Katsuyoshi Koh, MD, Akitoshi Kinoshita, MD PhD, Moeko Hino, MD, Toshihiko Imamura, MD PhD, Yozo Nakazawa, MD PhD, Okuya Mayuko, MD PhD, Harumi Kakuda, MD PhD, Masashi Sanada, MD, Kimikazu Matsumoto, MD, PhD, Daisuke Tomizawa, MD PhD, Nobutaka Kiyokawa, MD PhD, Akira Ohara, MD PhD, Atsushi Manabe, MD PhD, Kenichiro Hata, MD PhD, Jun J. Yang, PhD, Motohiro Kato, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2751.
https://doi.org/10.1182/blood-2019-125713
Published: 2019
Journal Articles

Clinical Feature and Genetic Alterations in Myeloid/Natural Killer (NK) Cell Precursor Acute Leukemia and Myeloid/NK Cell Acute Leukemia

Akira Nishimura, MD, Kazuaki Yokoyama, MD PhD, Chika Yamagishi, MD, Takuya Naruto, MD PhD, Tomohiro Morio, MD PhD, Akinori Kanai, PhD, Hirotaka Matsui, MD PhD, Naoko Higuchi, MD, Akiko Takada, MD, Haruna Okuno, MD, Shoji Saito, MD, Shuhei Karakawa, MD, Shogo Kobayashi, MD, Hideki Sano, MD, Takashi Koike, MD, Daisuke Hasegawa, MD PhD, Hiroyuki Fujisaki, MD, PhD, Daiichiro Hasegawa, MD PhD, Kazutoshi Koike, MD, Atsushi Ogawa, MD PhD, Akitoshi Kinoshita, MD PhD, Norio Shiba, MD PhD, Mizuka Miki, MD, Hideki Nakayama, MD, Yozo Nakazawa, MD, PhD, Toshihiko Imamura, MD PhD, Takashi Taga, MD PhD, Souichi Adachi, MD PhD, Katsuyoshi Koh, MD, Atsushi Manabe, MD PhD, Tomohiko Taki, MD PhD, Yasushi Ishida, MD PhD, Arinobu Tojo, MD PhD, Masatoshi Takagi, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2824.
https://doi.org/10.1182/blood-2018-99-118627
Published: 2018
Journal Articles

Effect of Age on the Prognosis of Molecular Abnormalities in Pediatric Acute Myeloid Leukemia

Yusuke Hara, MD PhD, Norio Shiba, MD PhD, Genki Yamato, MD PhD, Kentaro Ohki, MD PhD, Manabu Sotomatsu, MD PhD, Ken Tabuchi, MD, Daisuke Tomizawa, MD PhD, Tomohiko Taki, MD PhD, Akitoshi Kinoshita, MD PhD, Nobutaka Kiyokawa, MD PhD, Hirokazu Arakawa, MD PhD, Masabumi Shibuya, MD PhD, Takashi Taga, MD PhD, Akio Tawa, MD PhD, Keizo Horibe, MD PhD, Souichi Adachi, MD PhD, Yasuhide Hayashi, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1506.
https://doi.org/10.1182/blood-2018-99-118097
Published: 2018
Journal Articles

Biology and Prognostic Markers in Young Children with Acute Myeloid Leukemia -the Jccg Study, JPLSG AML-05-

Yusuke Hara, Norio Shiba, MD, Genki Yamato, MD, Jun Okubo, MD PhD, Kentaro Ohki, MD PhD, Myoung-Ja Park, MD PhD, Manabu Sotomatsu, MD PhD, Daisuke Tomizawa, MD PhD, Tomohiko Taki, MD PhD, Akitoshi Kinoshita, MD PhD, Nobutaka Kiyokawa, MD PhD, Takashi Taga, MD PhD, Hirokazu Arakawa, MD PhD, Akio Tawa, MD PhD, Keizo Horibe, Souichi Adachi, MD PhD, Yasuhide Hayashi, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1392.
https://doi.org/10.1182/blood.V130.Suppl_1.1392.1392
Published: 2017
Journal Articles

Effectiveness of Supportive Care Measurements to Reduce Infections during Induction for Children with Acute Myeloid Leukemia: A Report from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG)

Daiichiro Hasegawa, MD PhD, Takako Miyamura, MD PhD, Kozo Nagai, MD, Kazuko Kudo, MD PhD, Tawa Akio, MD PhD, Hirozumi Sano, MD, Keitaro Fukushima, MD, Shotaro Iwamoto, MD, Akitoshi Kinoshita, MD PhD, Hiroyuki Takahashi, Kiminori Terui, MD PhD, Hideki Nakayama, MD, Yuki Arakawa, MD, Kentaro Nakashima, MD, Shohei Yamamoto, MD PhD, Akiko Moriya Saito, MD PhD, Keizo Horibe, Daisuke Tomizawa, MD PhD, Takashi Taga, MD PhD, Souichi Adachi, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2588.
https://doi.org/10.1182/blood.V130.Suppl_1.2588.2588
Published: 2017
Journal Articles

Identification of Two Distinct Poor Prognostic Subgroups Related to High Expression of BMP2 or PRDM16 in Pediatric AML

Yusuke Hara, MD, Norio Shiba, MD PhD, Genki Yamato, MD, Jun Okubo, MD PhD, Kentaro Ohki, MD PhD, Myoung-Ja Park, MD PhD, Manabu Sotomatsu, MD, Daisuke Tomizawa, MD, PhD, Tomohiko Taki, MD PhD, Akitoshi Kinoshita, MD PhD, Nobutaka Kiyokawa, MD PhD, Takashi Taga, MD PhD, Hirokazu Arakawa, MD PhD, Akio Tawa, MD PhD, Keizo Horibe, MD PhD, Souichi Adachi, MD, PhD, Yasuhide Hayashi, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2854.
https://doi.org/10.1182/blood.V128.22.2854.2854
Published: 2016
Journal Articles

Distinct Clinical and Cytogenetic Characteristics and Poor Prognosis in Children with Acute Erythroid Leukemia: A Report from the JPLSG AML-05 Study

Daisuke Tomizawa, MD PhD, Akio Tawa, MD PhD, Nobutaka Kiyokawa, MDPhD, Akitoshi Kinoshita, MD PhD, Hayato Miyachi, MD PhD, Yuka Yamashita, MS, Keizo Horibe, MD PhD, Shotaro Iwamoto, MD PhD, Takao Deguchi, MD PhD, Norio Shiba, MD PhD, Hiroshi Moritake, MD PhD, Akira Shimada, MD PhD, Daisuke Hasegawa, MD PhD, Takashi Taga, MD PhD, Eiichi Ishii, MD PhD, Souichi Adachi, MD PhD
Journal: Blood
Blood (2015) 126 (23): 4945.
https://doi.org/10.1182/blood.V126.23.4945.4945
Published: 2015
Journal Articles

Prognostic Significance of CXCR4 Overexpression in Pediatric Acute Myeloid Leukemia with Low-Risk: A Report from the Japanese Pediatric Leukemia/Lymphoma Study Group

Hidemasa Matsuo, MS, Naomi Nakamura, MS, Daisuke Tomizawa, MD PhD, Akiko M. Saito, Nobutaka Kiyokawa, MDPhD, Keizo Horibe, MD PhD, Yoko Nishinaka-Arai, PhD, Mayu Tokumasu, MD, Hiroshi Itoh, MS, Yasuhiko Kamikubo, MD PhD, Hideki Nakayama, MD PhD, Akitoshi Kinoshita, MD PhD, Takashi Taga, MD PhD, Akio Tawa, MD PhD, Tomohiko Taki, MD PhD, Shiro Tanaka, PhD, Souichi Adachi, MD PhD
Journal: Blood
Blood (2015) 126 (23): 3814.
https://doi.org/10.1182/blood.V126.23.3814.3814
Published: 2015
Journal Articles

High Event-Free Survival Rate with Minimum-Dose-Anthracycline Treatment in Childhood Acute Promyelocytic Leukemia: A Nationwide Prospective Study By the Japanese Pediatric Leukemia / Lymphoma Study Group (JPLSG)

Hiroyuki Takahashi, MD PhD, Tomoyuki Watanabe, PhD, Akitoshi Kinoshita, MD PhD, Yuki Yuza, MD PhD, Hiroshi Moritake, MD PhD, Kiminori Terui, MD PhD, Shotaro Iwamoto, MD PhD, Hideki Nakayama, MD PhD, Akira Shimada, MD PhD, Kazuko Kudo, MDPhD, Tomohiko Taki, MD PhD, Miharu Yabe, MD PhD, Hiromichi Matsushita, MD PhD, Yuka Yamashita, PhD, Kazutoshi Koike, MD, Atsushi Ogawa, MD, Yoshiyuki Kosaka, MD, Daisuke Tomizawa, MD PhD, Takashi Taga, MD PhD, Akiko M. Saito, MD PhD, Keizo Horibe, MD, Tatsutoshi Nakahata, MD PhD, Hayato Miyachi, MD PhD, Akio Tawa, MD PhD, Souichi Adachi, MDPhD
Journal: Blood
Blood (2014) 124 (21): 956.
https://doi.org/10.1182/blood.V124.21.956.956
Published: 2014
Journal Articles

Outcome of Adolescent and Young Adults with Acute Myeloid Leukemia Treated with Pediatric Protocols: A Report from the 3 Japanese Cooperative Studies

Daisuke Tomizawa, MD PhD, Tomoyuki Watanabe, PhD, Ryoji Hanada, MD, Keizo Horibe, MD PhD, Yasuo Horikoshi, MD, Shotaro Iwamoto, MD PhD, Akitoshi Kinoshita, MD PhD, Hiroshi Moritake, MD PhD, Hideki Nakayama, MD PhD, Akira Shimada, MD PhD, Takashi Taga, MD PhD, Hiroyuki Takahashi, MD PhD, Akio Tawa, MD PhD, Kiminori Terui, MD PhD, Hiroki Hori, MD, Yoshifumi Kawano, MD PhD, Atsushi Kikuta, MD PhD, Atsushi Manabe, MD PhD, Souichi Adachi, MD PhD
Journal: Blood
Blood (2014) 124 (21): 374.
https://doi.org/10.1182/blood.V124.21.374.374
Published: 2014
Journal Articles

Poor Prognosis Associated with FAB Subtypes M4 and M5 in Japanese Pediatric Acute Myeloid Leukemia Patients with FLT3 -ITD

Yusuke Hara, MD, Norio Shiba, MDPhD, Kentaro Ohki, MD PhD, Myoung-ja Park, MD PhD, Akira Shimada, MD PhD, Daisuke Tomizawa, MD PhD, Akiko Moriya Saito, MD PhD, Junichiro Fujimoto, MD PhD, Tomohiko Taki, MD PhD, Akitoshi Kinoshita, MD PhD, Takashi Taga, MD PhD, Hirokazu Arakawa, MDPhD, Akio Tawa, MD PhD, Keizo Horibe, MD PhD, Souichi Adachi, MD PhD, Yasuhide Hayashi, MD PhD
Journal: Blood
Blood (2014) 124 (21): 1002.
https://doi.org/10.1182/blood.V124.21.1002.1002
Published: 2014
Journal Articles

Risk-Oriented Therapy for Myeloid Leukemia of Down Syndrome: A Nationwide Prospective Study By the Japanese Pediatric Leukemia / Lymphoma Study Group (JPLSG)

Takashi Taga, MD PhD, Tomoyuki Watanabe, Kazuko Kudo, MDPhD, Daisuke Tomizawa, MD PhD, Kiminori Terui, MD PhD, Hiroshi Moritake, MD PhD, Akitoshi Kinoshita, MD PhD, Shotaro Iwamoto, MD PhD, Hideki Nakayama, MD PhD, Hiroyuki Takahashi, MD PhD, Akira Shimada, MD PhD, Tomohiko Taki, MD PhD, Tsutomu Toki, PhD, Etsuro Ito, MD PhD, Hiroaki Goto, MD, PhD, Katsuyoshi Koh, MD, Akiko M. Saito, MD PhD, Keizo Horibe, MD PhD, Tatsutoshi Nakahata, MD PhD, Akio Tawa, MD PhD, Souichi Adachi, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3668.
https://doi.org/10.1182/blood.V124.21.3668.3668
Published: 2014
Journal Articles

Double CEBPA Mutations Are Not Associated With Favorable Clinical Outcome In Pediatric AML: A Report From The Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG)

Hidemasa Matsuo, MT (ASCPi), Mio Kajihara, Daisuke Tomizawa, MD, PhD, Tomoyuki Watanabe, PhD, Akiko Moriya Saito, MD, PhD, Junichiro Fujimoto, MD, PhD, Keizo Horibe, MD, PhD, Mayu Tokumasu, MD, Hiroshi Itoh, Hideki Nakayama, MD, PhD, Akitoshi Kinoshita, MD, PhD, Takashi Taga, MD, PhD, Akio Tawa, MD, PhD, Tomohiko Taki, MD, PhD, Souichi Adachi, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 4942.
https://doi.org/10.1182/blood.V122.21.4942.4942
Published: 2013
Journal Articles

Poor Prognosis With Different Induction Rate Was Observed In Children With Acute Myeloid Leukemia and FLT3 -ITD According To The ITD/WT Allelic Ratio: A Result From The Japanese Pediatric Leukemia/Lymphoma Study Group

Akira Shimada, MD., PhD, Yuka Yamashita, MS, Daisuke Tomizawa, MD, PhD, Akio Tawa, MD, PhD, Tomoyuki Watanabe, PhD, Toshiya Yokozawa, MD, PhD, Kazuko Kudo, MD, PhD, Takashi Taga, MD, PhD, Shotaro Iwamoto, MD, PhD, Kiminori Terui, MD, PhD, Hiroshi Moritake, MD, PhD, Akitoshi Kinoshita, MD, PhD, Hiroyuki Takahashi, MD, PhD, Hideki Nakayama, MD., PhD, Katsuyoshi Koh, MD, Hiroaki Goto, MD., PhD, Yoshiyuki Kosaka, MD, PhD, Akiko Moriya Saito, MD, PhD, Junichiro Fujimoto, MD, PhD, Keizo Horibe, MD, PhD, Kentaro Oki, MD, PhD, Yasuhide Hayashi, MD, PhD, Souichi Adachi, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 3891.
https://doi.org/10.1182/blood.V122.21.3891.3891
Published: 2013
Journal Articles

Significance Of Minimal Residual Disease Detected By Multi-Color Flow Cytometry In Childhood Acute Myeloid Leukemia With The Intermideate-Risk Cytogenetics and Negative FMS-Like Tyrosine Kinase 3 Internal Tandem Duplication: A Report Of The Tokyo Children's Cancer Study Group

Dai Keino, MD, Akitoshi Kinoshita, MD, PhD, Daisuke Tomizawa, MD, PhD, Hiroyuki Takahashi, MD, PhD, Kohmei Ida, MD, Hidemitsu Kurosawa, MD, Kazutoshi Koike, MD, Setsuo Ota, MD, Noriyuki Iwasaki, MD, Junya Fujimura, MD, Yuki Yuza, MD, Chikako Kiyotani, MD, Shohei Yamamoto, MD, PhD, Tomoo Osumi, MD, Takahiro Ueda, MD, PhD, Shinji Mochizuki, MD, PhD, Keiichi Isoyama, MD, Ryoji Hanada, MD, Akio Tawa, MD, PhD, Akira Kikuchi, MD, PhD, Atsushi Manabe, MD, PhD, Akira Ohara, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1416.
https://doi.org/10.1182/blood.V122.21.1416.1416
Published: 2013
Journal Articles

AML with Recurrent Genetic Abnormalities and AML with Myelodysplasia-Related Changes Account for Three-Quarters of Previously Untreated Pediatric AML-the Results of a Nation-Wide Central Review in Japan-

Akitoshi Kinoshita, MD, PhD, Hayato Miyachi, MD, PhD, Hiromichi Matsushita, MD, PhD, Tomohiko Taki, MD, PhD, Miharu Yabe, MD, PhD, Nobutaka Kiyokawa, MD, PhD, Kiminori Terui, MD, Hashii Yoshiko, MD, Takao Deguchi, MD, Hiroyuki Takahashi, MD, PhD, Takashi Taga, MD, Yasuhide Hayashi, MD, PhD, Akio Tawa, MD, PhD, Souichi Adachi, MD, PhD, Masahito Tsurusawa, MD, Keizo Horibe, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 4899.
https://doi.org/10.1182/blood.V118.21.4899.4899
Published: 2011
Journal Articles

Refractory / Relapsed Myeloid Leukemia of Down Syndrome Is Resistant to Second-Line Chemotherapy and Hardly Salvaged by Hematopoietic Stem Cell Transplantation: A Retrospective Study by the Japanese Pediatric Leukemia / Lymphoma Study Group (JPLSG)

Takashi Taga, MD, PhD, Akiko Saito, MD, PhD, Kazuko Kudo, MD, PhD, Daisuke Tomizawa, MD, Kiminori Terui, MD, PhD, Hiroshi Moritake, MD, PhD, Akitoshi Kinoshita, MD, PhD, Shotaro Iwamoto, MD, PhD, Hideki Nakayama, MD, Hiroyuki Takahashi, MD, PhD, Akio Tawa, MD, PhD, Akira Shimada, MD, PhD, Tomohiko Taki, MD, PhD, Hisato Kigasawa, MD, Katsuyoshi Koh, MD, Souichi Adachi, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 4276.
https://doi.org/10.1182/blood.V118.21.4276.4276
Published: 2011
Journal Articles

Heterogeneity in Infants with Acute Myeloid Leukemia: Retrospective Analysis of a Japanese Nationwide Survey

Akira Shimada, MD, PhD, Daisuke Tomizawa, MD, Akitoshi Kinoshita, MD, PhD, Kazuko Hamamoto, MD., PhD, Ichiro Tsukimoto, MD., PhD, Atsushi Ogawa, MD, Takashi Taga, MD, PhD, Toshihiko Imamura, MD, PhD, Akio Tawa, MD, PhD, Keizo Horibe, MD, PhD, Tomohiko Taki, MD, PhD, Yasuhide Hayashi, MD, PhD, Souichi Adachi, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 1477.
https://doi.org/10.1182/blood.V118.21.1477.1477
Published: 2011
Journal Articles

A Rapid Approach for the Integrated Central Review of Acute Myeloid Leukemia Diagnosis In a Nationwide Clinical Trial for Children

Akitoshi Kinoshita, MD, PhD, Hayato Miyachi, MD, PhD, Hiromichi Matsushita, MD, PhD, Tomohiko Taki, MD, PhD, Miharu Yabe, MD, PhD, Nobutaka Kiyokawa, MD, PhD, Kiminori Terui, MD, PhD, Hideaki Ohta, MD, PhD, Takao Deguchi, MD, PhD, Hiroyuki Takahashi, MD, PhD, Takashi Taga, MD, PhD, Yasuhide Hayashi, MD, PhD, Akio Tawa, MD, PhD, Souichi Adachi, MD, PhD, Masahito Tsurusawa, MD, PhD, Keizo Horibe, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 4833.
https://doi.org/10.1182/blood.V116.21.4833.4833
Published: 2010