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A. Thomas Look, M.D.
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Journal Articles

Epigenetic Therapy Inhibits NUP98-HOXA9 -Mediated Myeloid Disease – Decitabine and Valproic Acid Work Synergistically to Rescue Normal Hematopoiesis in Transgenic Zebrafish.

Adam Deveau, BSc(Hons), A. Michael Forrester, PhD, Clemens Grabher, Andrew J Coombs, BSc(Hon), Ian Chute, MSc, Daniel Leger, MSc, Stephen Lewis, PhD, A. Thomas Look, M.D., Jason N Berman, MD
Journal: Blood
Blood (2012) 120 (21): 2391.
https://doi.org/10.1182/blood.V120.21.2391.2391
Published: 2012
Journal Articles

The TAL1 Complex Represses the FBXW7 Tumor Suppressor Through Mir-223 in Human T-Cell Acute Lymphoblastic Leukemia

Marc R Mansour, MD FRCPath, Takaomi Sanda, MD, PhD, Lee N Lawton, PhD, Xiaoyu Li, MD, PhD, Taras Kreslavsky, PhD, Carl Novina, MD PhD, Harald von Boehmer, MD PhD, Richard Young, PhD, A. Thomas Look, M.D.
Journal: Blood
Blood (2012) 120 (21): 1296.
https://doi.org/10.1182/blood.V120.21.1296.1296
Published: 2012
Journal Articles

Phenothiazines Induce Apoptosis in T-Cell Acute Lymphoblastic Leukemia by Activating the Phosphatase Activity of the PP2A Tumor Suppressor

Alejandro Gutierrez, MD, Alex Kentsis, MD, PhD, Li Pan, PhD, Frederic Baleydier, M.D Ph.D, Jason Marineau, PhD, Ruta Grebliunaite, Elena Kozakewich, Casie Reed, BS, Francoise Pflumio, Sandrine Poglio, Benjamin Uzan, Paul A. Clemons, Lynn VerPlank, W. Frank An, Jason Burbank, Stephanie Norton, Nicola J Tolliday, PhD, Hanno Steen, PhD, James E Bradner, MD, A. Thomas Look, M.D., Jon C Aster, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3558.
https://doi.org/10.1182/blood.V120.21.3558.3558
Published: 2012
Journal Articles

L-Leucine Improves the Anemia of DBA and the 5q- Syndrome Via Activation of the mTOR Pathway in a p53-Independent Manner

Nirmalee Abayasekara, MS, Anupama Narla, Slater Hurst, BS, Hong Sun, MD, Maria Virgilio, Elspeth Payne, Benjamin L. Ebert, MD, PhD, A. Thomas Look, M.D., Nancy Berliner, MD, Arati Khanna-Gupta, PhD
Journal: Blood
Blood (2012) 120 (21): 1257.
https://doi.org/10.1182/blood.V120.21.1257.1257
Published: 2012
Journal Articles

Mutationally Activated TYK2 From T-ALL Specimens Exhibits Tranformative Capacity in Cell Lines and Primary Cell Models and T-Lineage Expansion in Mice

Angela G. Fleischman, MD, PhD, Takaomi Sanda, MD, PhD, Alejandro Gutierrez, MD, Samuel B Luty, Stephanie G Willis, A. Thomas Look, M.D., Brian J. Druker, Jeffrey W Tyner, PhD
Journal: Blood
Blood (2011) 118 (21): 74.
https://doi.org/10.1182/blood.V118.21.74.74
Published: 2011
Journal Articles

Core Transcriptional Regulatory Circuit Controlled by the TAL1 Complex in T-Cell Acute Lymphoblastic Leukemia,

Takaomi Sanda, M.D., Ph.D., Lee N Lawton, PhD, M Inmaculada Barrasa, Ph.D., Zi Peng Fan, Yebin Ahn, Richard Young, PhD, A. Thomas Look, M.D.
Journal: Blood
Blood (2011) 118 (21): 3453.
https://doi.org/10.1182/blood.V118.21.3453.3453
Published: 2011
Journal Articles

NOTCH1 Signaling Defines a Leukemia Initiating Cell Population in T-Cell Acute Lymphoblastic Leukemia

Wenxue Ma, M.D., Ph.D., Kristen M. Smith, Ph.D., Alejandro Gutierrez, M.D., Heather S. Leu, B.S., Qingfei Jiang, Ph.D., Christina C.N. Wu, Ph.D., Alice Y. Shih, B.S., Angela C. Court-Recart, M.S., Anil Sadarangani, Ph.D., Daniel J. Goff, B.S., Ping Wei, Ph.D., A. Thomas Look, M.D., Catriona H.M. Jamieson, M.D., Ph.D.
Journal: Blood
Blood (2011) 118 (21): 1507.
https://doi.org/10.1182/blood.V118.21.1507.1507
Published: 2011
Journal Articles

NOTCH1-Induced T-Cell Leukemia in Transgenic Zebrafish.

Jihua Chen, PhD, Cicely Jette, Ph.D., John P. Kanki, Ph.D., Jon Aster, M.D.,Ph.D., A. Thomas Look, M.D., James D. Griffin, M.D.
Journal: Blood
Blood (2006) 108 (11): 1825.
https://doi.org/10.1182/blood.V108.11.1825.1825
Published: 2006
Journal Articles

CD34+ Cell Selection Is Required to Accurately Measure HOXA9 Levels by Quantitative RT-PCR in Patients with Myelodysplastic Syndrome.

Jason N. Berman, M.D., Stefan Heinrichs, PhD., Taylor M. Ortiz, M.D., Steven M. Kornblau, M.D., Donna S. Neuberg, ScD., Elihu H. Estey, M.D., A. Thomas Look, M.D.
Journal: Blood
Blood (2004) 104 (11): 4733.
https://doi.org/10.1182/blood.V104.11.4733.4733
Published: 2004
Journal Articles

Slug Plays an Essential Role in the Radioprotection of Hematopoietic Progenitors In Vivo by Antagonizing p53-Mediated Apoptotic Pathways.

Wen-Shu Wu, Ph.D., Dong Xu, M.D., Stefan Heinrichs, Ph.D., A. Thomas Look, M.D.
Journal: Blood
Blood (2004) 104 (11): 31.
https://doi.org/10.1182/blood.V104.11.31.31
Published: 2004
Journal Articles

Epigenetic Suppression of the CTNNA1 Gene, Encoding the α-Catenin Protein, which Is Located in the 5q31 Critical Deleted Region in Malignant Myeloid Disorders with del(5q).

Ting Xi Liu, M.D., Ph.D., Michael Becker, M.D., Karl Hsu, M.D., Jaroslav Jelinek, M.D., Ph.D., Min Deng, M.D., Clara Bloomfield, M.D.4, Jean-Pierre Issa, M.D., Michael F. Clarke, M.D., A. Thomas Look, M.D.4
Journal: Blood
Blood (2004) 104 (11): 203.
https://doi.org/10.1182/blood.V104.11.203.203
Published: 2004
Journal Articles

Identification of TAL1/SCL Target Genes through siRNA and Microarray Expression Analysis.

Jennifer O’Neil, Ph.D., Adolfo A. Ferrando, M.D., Ph.D., Teresa Palomero, Ph.D., A. Thomas Look, M.D.
Journal: Blood
Blood (2004) 104 (11): 4294.
https://doi.org/10.1182/blood.V104.11.4294.4294
Published: 2004