The microbiota, comprising bacteria, fungi, and viruses residing within our body, functions as a key modulator in host health and states, including immune responses. Studies have linked microbiota and microbiota-derived metabolites to immune cell functions. In this review, we probe the complex relationship between the human microbiota and clinical outcomes of cellular therapies that leverage immune cells to fight various cancers. With a particular emphasis on hematopoietic cell transplantation and chimeric antigen receptor T cell therapy, we explore the potential mechanisms underpinning this interaction. We also highlight the interventional applications of the microbiota in cellular therapy, while outlining future research directions in the field.
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Review Article|
August 14, 2024
The intestinal microbiota and cellular therapy: implications for impact and mechanisms
Jiayi Xie,
Jiayi Xie
Stanford University, Stanford, California, United States
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Melody Smith
Stanford University, Stanford, California, United States
* Corresponding Author; email: melodysm@stanford.edu
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Blood blood.2024024219.
Article history
Submitted:
May 2, 2024
Revision Received:
June 25, 2024
Accepted:
July 16, 2024
Citation
Jiayi Xie, Melody Smith; The intestinal microbiota and cellular therapy: implications for impact and mechanisms. Blood 2024; blood.2024024219. doi: https://doi.org/10.1182/blood.2024024219
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