Recent advancements in single-cell genomics have enriched our understanding of hematopoiesis, providing intricate details about hematopoietic stem cell (HSC) biology, differentiation, and lineage commitment. Technological advancements have highlighted extensive heterogeneity of cell populations and continuity of differentiation routes. Nevertheless, intermediate 'attractor' states signify structure in stem and progenitor populations that link state transition dynamics to fate potential. We discuss how innovative model systems quantify lineage bias and how stress accelerates differentiation, thereby reducing fate plasticity compared to native hematopoiesis. We conclude by offering our perspective on the current model of hematopoiesis and discuss how a more precise understanding can translate to strategies that extend healthy hematopoiesis and prevent disease.
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Research Article|
July 10, 2024
New frameworks for hematopoiesis derived from single-cell genomics
Ksenia Safina,
Ksenia Safina
Brigham and Women's Hospital, Boston, Massachusetts, United States
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Peter van Galen
Brigham and Women's Hospital, Boston, Massachusetts, United States
* Corresponding Author; email: pvangalen@bwh.harvard.edu
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Blood blood.2024024006.
Article history
Submitted:
April 25, 2024
Revision Received:
June 21, 2024
Accepted:
June 22, 2024
Citation
Ksenia Safina, Peter van Galen; New frameworks for hematopoiesis derived from single-cell genomics. Blood 2024; blood.2024024006. doi: https://doi.org/10.1182/blood.2024024006
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