Intravenous injection of excess apo-transferrin enhances dietary iron absorption in mice, and triggers accumulation of plasma non-transferrin bound iron (NTBI). Injected fluorescent-labeled transferrin colocalizes with lamina propria macrophages, consistent with the recently proposed iron absorption checkpoint involving macrophage-mediated transferrin degradation.
Subjects:
Red Cells, Iron, and Erythropoiesis
This content is only available as a PDF.
Copyright © 2024 American Society of Hematology
2024
You do not currently have access to this content.
This feature is available to Subscribers Only
Sign In or Create an Account Close Modal