The total number of in vitro stem cells (CFUc) is lower in AKR leukemic mice than in nonleukemic AKR mice of the same age. This decrease is caused by a drop in the bone marrow CFUcs which is not compensated for by an increase in the number of these cells in the spleen. This decrease in CFUcs is not due to the presence of leukemic cells in the cultures, nor to the age of the mice, nor to a modified response to the stimulating factor (CSF) of CFUcs in leukemic mice.

This content is only available as a PDF.
© 1974 by American Society of Hematology, Inc.
1974
Sign in via your Institution