Extrarenal erythropoietin production is increased above normal in lead-injected rats exposed to hypoxia either immediately after or 1 day after nephrectomy. Extrarenal erythropoietin production in lead-poisoned rats is actinomycin D sensitive, and the major extrarenal site of production or activation of the hormone in normal or lead-poisoned anephric rats is the liver.

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© 1974 by American Society of Hematology, Inc.
1974
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