Familial Immunopathy With Chromosomal and Functional Abnormalities of Lymphocytes

Lymphocytes from members of a family with multiple immunologic disorders had abnormal chromosomes and defective in vitro function. The clinical findings ranged from agammaglobulinemia in the propositus to periarteritis nodosa in his grandnephew. The wife of the propositus was clinically healthy, but her lymphocytes were hyporeactive when cultured with nonspecific mitogens. The high incidence of lymphocyte abnormalities in the children may be the result of the mating of two individuals who have abnormal lymphocytes.