The hematopoietic effects of both single and repeated intravenous injections of moderate concentrations of Vincristine Sulfate on rabbit erythropoiesis have been presented. A prompt depopulation of erythroid elements results and is almost completed by 48 hours. Following this depression a rapid rebound of erythropoietic activity occurs. Serum iron values reflect these changes in iron utilization. The reproducibility of these extremes in marrow erythropoietic activity allows one to use the Vincristine Sulfate treated rabbit as an experimental model. It will allow us to study the factors which regulate the balance between erythropoiesis and iron kinetics.

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© 1969 by American Society of Hematology, Inc.
1969
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