Myasthenia gravis and roentgenologic evidence of a mass in the anterior mediastinum appeared in a patient with chronic myeloid leukemia following busulfan treatment.

X-ray irradiation of the thymic area and subsequent surgical removal of the anterior mediastinal mass were followed by remission from the myasthenia gravis. Histologic examination of the mass showed involuted thymic remnants without evidence of leukemic infiltration or of malignant thymoma.

The possible etiology of the myasthenia gravis in this patient, with special reference to a busulfan-induced autoimmune process, is discussed.

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© 1968 by American Society of Hematology, Inc.
1968
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