The production of granulocytic progeny by transplanted mouse bone marrow is described. Normal marrow is injected into lethally irradiated recipients. Seven to 9 days is allowed for stem cells in the marrow to proliferate and differentiate. The granulocytic response to a bacterial endotoxin is then measured. This response bears a linear relationship with the number of bone marrow cells injected and can be used as an assay of granulocytic progenitor cells in bone marrow.

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© 1967 by American Society of Hematology, Inc.
1967
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