Two δ-Chain Abnormal Hemoglobins in One Individual

Two abnormal minor hemoglobin components have been detected in the blood of a healthy Negro male. One component which was identified as the δ-chain abnormality Hb-A₂' was inherited from the mother, whereas the second component, being identical with Hb-Flatbush_Ga, was inherited from the father. The complete absence of Hb-A₂ in this individual definitely establishes the relationship of allelism between Hb-A₂ and Hb-Flatbush_Ga. Hb-Flatbush_Ga, therefore, is the second hemoglobin abnormality for which indirect proof for allelism with Hb-A₂ has been obtained; the discovery of three homozygous carriers of Hb-A₂' (2 of these cases have been mentioned before,⁴ showing complete absence of Hb-A₂) already established a similar relationship between Hb-A₂ and Hb-A₂'.