In mice and in dogs, the usefulness of infusions of marrow in reducing the toxicity of thio-TEPA is limited to a very narrow range of dose of drug in which prompt restoration of hematopoiesis seems critical to survival. Below this range, control animals recover spontaneously; above this range, damage to other organ systems precludes survival.

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© 1963 by American Society of Hematology, Inc.
1963
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