Catheptic Activity of Leukocytes in Normal and Leukemic Subjects

1. A method has been described for the determination of the catheptic activity of leukocytes.

2. The catheptic activity of the leukocytes of normal and leukemic individuals has been investigated.

3. The leukocytes from all cases of untreated lymphatic leukemia, either chronic or acute, show lower catheptic activity than the leukocytes from any of the untreated myelogenous leukemias, either chronic or acute; the values for normal cases ranged between these two classes with much overlap.

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4. The lymphocyte fractions separated from the blood of normal subjects possess essentially the same catheptic activity as the total unfractionated leukocyte populations.

5. An attempt to isolate granulocytes from the blood of normal subjects for separate analysis was not successful.