Abstract

Human herpesvirus 6 reactivation in chimeric antigen receptor T-cell recipients is reported to be rare. Our patient cohort (n = 119) experienced a sevenfold higher incidence of viremia than a previous study and 2 cases of encephalitis. Further studies are needed to determine risk factors for infection.

1.
Kampouri
E
,
Krantz
EM
,
Xie
H
, et al
.
Human herpesvirus 6 reactivation and disease are infrequent in chimeric antigen receptor T-cell therapy recipients
.
Blood
.
2024
;
144
(
5
):
490
-
495
.
2.
Peggs
KS
.
Human herpesvirus 6 and CAR T-cell toxicity
.
Blood
.
2024
;
144
(
5
):
465
-
466
.
3.
Handley
G
,
Hasbun
R
,
Okhuysen
P
.
Human herpesvirus 6 and central nervous system disease in oncology patients: a retrospective case series and literature review
.
J Clin Virol
.
2021
;
136
:
104740
.
4.
Rebechi
MT
,
Bork
JT
,
Riedel
DJ
.
HHV-6 encephalitis after chimeric antigen receptor T-cell therapy (CAR-T): 2 case reports and a brief review of the literature
.
Open Forum Infect Dis
.
2021
;
8
(
11
):
ofab470
.
5.
Ward
KN
,
Hill
JA
,
Hubacek
P
, et al
.
Guidelines from the 2017 European Conference on Infections in Leukaemia for management of HHV-6 infection in patients with hematologic malignancies and after hematopoietic stem cell transplantation
.
Haematologica
.
2019
;
104
(
11
):
2155
-
2163
.
6.
Handley
G
.
Current role of prospective monitoring and preemptive and prophylactic therapy for human herpesvirus 6 after allogeneic stem cell transplantation
.
Open Forum Infect Dis
.
2022
;
9
(
8
):
ofac398
.
7.
Hill
JA
,
Boeckh
MJ
,
Sedlak
RH
,
Jerome
KR
,
Zerr
DM
.
Human herpesvirus 6 can be detected in cerebrospinal fluid without associated symptoms after allogeneic hematopoietic cell transplantation
.
J Clin Virol
.
2014
;
61
(
2
):
289
-
292
.
8.
Ogata
M
,
Satou
T
,
Kawano
R
, et al
.
Plasma HHV-6 viral load-guided preemptive therapy against HHV-6 encephalopathy after allogeneic stem cell transplantation: a prospective evaluation
.
Bone Marrow Transplant
.
2008
;
41
(
3
):
279
-
285
.
9.
Brennan
Y
,
Gottlieb
DJ
,
Baewer
D
,
Blyth
E
.
A fatal case of acute HHV-6 myocarditis following allogeneic haemopoietic stem cell transplantation
.
J Clin Virol
.
2015
;
72
:
82
-
84
.
10.
Ogata
M
,
Oshima
K
,
Ikebe
T
, et al
.
Clinical characteristics and outcome of human herpesvirus-6 encephalitis after allogeneic hematopoietic stem cell transplantation
.
Bone Marrow Transplant
.
2017
;
52
(
11
):
1563
-
1570
.
11.
Handley
G
,
Khawaja
F
,
Kondapi
DS
, et al
.
Human herpesvirus 6 myelitis after chimeric antigen receptor T-cell therapy
.
Int J Infect Dis
.
2021
;
112
:
327
-
329
.
12.
Shah
M
,
Kuhnl
A
,
Shields
G
, et al
.
Human herpesvirus 6 encephalitis following axicabtagene ciloleucel treatment for refractory diffuse large B cell lymphoma
.
Hemasphere
.
2021
;
5
(
3
):
e535
.
13.
Li
N
,
Zhang
R
,
Wang
J
, et al
.
Case report: acute HHV6B encephalitis/myelitis post CAR-T cell therapy in patients with relapsed/refractory aggressive B-cell lymphoma
.
Front Neurol
.
2024
;
15
:
1334000
.
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