Risk assessment systems, including International Prognosis Score of thrombosis in Essential Thrombocythemia (IPSET-t), have been developed to predict the risk of thrombosis in essential thrombocythemia (ET) patients. However, these systems have not been extensively validated. This study aims to assess the clinical utility of conventional risk stratification, IPSET-t, and a revised IPSET-t system in Korean ET patients. Additionally, this study identified markers that could predict thrombosis in ET using routine laboratory test results.

A total of 359 ET patients were diagnosed through blood tests, bone marrow tests, genetic tests, and chromosome tests. Markers that predict thrombosis were identified using blood tests and clinical chemistry test results performed at the time of diagnosis. The patients were classified using conventional risk stratification, IPSET-t, and revised IPSET-t systems.

The average age of ET patients was 61.8 years with 52.9% of female patients. Chromosomal abnormalities were observed in 5.1% of patients. Thrombosis-free survival (TFS) analysis revealed statistically significant differences in survival between the low and high-risk groups without showing statistical significance. No differences in progression-free survival (PFS) were observed between groups for the IPSET-t and revised IPSET-t risk prediction systems. White blood cell (WBC) count, neutrophil to lymphocyte ratio (NLR) and lactate dehydrogenase (LDH) levels were significantly associated with risk stratification, with higher values observed in higher-risk categories.

Three risk assessment systems were confirmed to be useful in predicting TFS but showed limitations in predicting PFS. Meanwhile, the WBC count, NLR and LDH levels were useful as blood test markers for predicting the prognosis.

Disclosures

No relevant conflicts of interest to declare.

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2024
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