Flow cytometry plays a prominent role in immunophenotyping malignant hematological disorders. However, in the context of chronic myeloid leukemia in chronic phase (CML-CP), flow cytometry serves primarily as an auxiliary diagnostic tool. This study involved the analysis of 500 patients diagnosed with chronic myeloid leukemia (CML) and 106 patients without CML using flow cytometry. Significance testing between the CML and non-CML groups was conducted using logistic regression to assess diagnostic value. The analysis revealed significant differences (p<0.01) in markers such as Neu%, Baso%, CD10%, CD38%, CD56%, CD64+CD16-%, CD15+CD11b+%, and Eos% between the CML and non-CML groups. Five significant markers were identified and used to construct a formula for CML diagnosis. The area under the ROC curve (AUC) demonstrated a value of 0.989, with a sensitivity of 98.0% and a specificity of 96.2%. Notably, potential diagnostic markers for chronic myeloid leukemia in chronic phase (CML-CP) were identified, and a diagnostic formula was constructed. These findings suggest a potentially crucial role for flow cytometry in the initial diagnosis of chronic myeloid leukemia in chronic phase (CML-CP).

Disclosures

No relevant conflicts of interest to declare.

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2024
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