Page 2335: In the upper row of Figure 3E, a duplicate copy of the MUNC13-4 WT plot was inadvertently inserted in place of the E379K (P11) plot. The percentages of cells shown in the E379K (P11) plot are correct, and the error does not alter the conclusions of the study or the interpretation of the data in the figure. The corrected Figure 3E is shown below.
Functional properties of MUNC13-4 mutants identified in case #1 (P6) and #2 (P11) and reconstituted in Unc13d KO mouse CTLs. (E) Degranulation assay, as measured by LAMP-1/CD107a externalization of Unc13d deficient mouse CTLs transduced with E379K-MUNC13-4, using SIINFEKL peptide-pulsed EL4 target cells.
Functional properties of MUNC13-4 mutants identified in case #1 (P6) and #2 (P11) and reconstituted in Unc13d KO mouse CTLs. (E) Degranulation assay, as measured by LAMP-1/CD107a externalization of Unc13d deficient mouse CTLs transduced with E379K-MUNC13-4, using SIINFEKL peptide-pulsed EL4 target cells.
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