By studying the behavior of the resistance of leukocytes to hypotonic saline solution we have found that leukocytes leaving the spleen are much less resistant than those entering it.

It is felt that the change in resistance affecting leukocytes on their passage through the spleen is in all probability the manifestation of one of the mechanisms by which the spleen regulates the life span of leukocytes.

Topics:
hypotonicity, leukocytes, oryctolagus cuniculus, osmosis, saline solutions, spleen
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© 1957 by American Society of Hematology, Inc.
1957
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