Abstract
Abstract 1041
Several studies suggest that subnormal vitamin D levels may be prognostic in a number of malignancies, including non Hodgkin lymphoma, prostate, breast, colon and lung cancer. However, no studies have evaluated the impact of subnormal vitamin D levels on treatment outcome in AML. Vitamin D levels were evaluated in 97 consecutive newly diagnosed similarly treated patients with AML (excluding AML M3). There were 50 (52%) males and 47 (48%) females with a median age of 60 years (range 19–91). The median white blood cell (WBC) count at diagnosis was 18×109/L (range 0.57–555.23). Karyotype was favorable in 11%, intermediate in 50%, adverse in 23%, of unknown significance in 11% and not available in 5%. A total of 74 patients (76%) had de novo AML. Albumin levels were subnormal (<3.5g/dl) in 33 (34%) patients and normal (≥3.5g/dl) in 64 (66%) patients. Body mass index (BMI) was calculated on all patients, normal weight (BMI 18–24.9) 33 (32%) patients, overweight (BMI 25–29.9) 34 (35%) patients, obese (BMI 30–34.9) 16 (16%) and very obese (BMI ≥35) 15 (15%) patients. Induction consisted of cytarabine (100mg/m2 × 7 days), daunorubicin (90mg/m2 for <60 and 60mg/m2, for ≥60 × 3 days) and etoposide (100mg/m2 × 3 days) (ADE 7+3+3).
No relevant conflicts of interest to declare.
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