Abstract
B cell receptor (BCR) signaling plays an essential role in the pathogenesis of chronic lymphocytic leukemia. In a subset of patients with a poor clinical outcome, BCR ligation leads to increased cell metabolism and cell survival (
Cancer Research
66
, 7158
–66, 2006
Statistical analysis showed a significant correlation between CLL dasatinib response and their IgVH mutation and ZAP70 status. Cases with worse prognoses by these criteria have a better response to the kinase inhibitor. Lastly, we have also found that ZAP70 positive cases showed a greater degree of PLC
Disclosures: Leonard:Bristol-Myers Squibb Research & Development: served in the past as a paid consultatnt/advisor to BMS. Lee:Bristol-Myers Squibb Research & Development: Employment.
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2008, The American Society of Hematology
2008
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