Abstract
The major challenge in treatment of early stage HL has been to achieve excellent treatment results while reducing short and long-term toxicities. Radiation therapy (RT) is a major cause of long-term toxicity. Doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD) is the established standard chemotherapy regimen for HL. Treatment results in early stage HL with ABVD alone are similar to those with ABVD + RT. Bleomycin pulmonary toxicity is the major cause of short-term morbidity and mortality. Gemcitabine is one of the most active single agents for relapsed/refractory HL with response rates 39–43%, and promising results have been reported in CALGB 59804 in relapsed HL with gemcitabine, vinorelbine and liposomal doxorubicin (
Author notes
Disclosure:Off Label Use: Gemcitabine does not have FDA approval for treatment of Hodgkin lymphoma.
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