Abstract
Older AML patients have short disease-free survival (DFS) and overall survival (OS) with current therapies; new approaches are needed. CALGB 9720 was a phase III trial evaluating multidrug resistance (MDR) modulation by PSC-833 (valspodar) in induction and consolidation therapy and subcutaneous IL-2 maintenance therapy. The PSC-833-containing arm was closed because of excessive toxicity after randomization of 120 patients, as reported previously (
Blood
100
:1224
, 2002
Disclosure: No relevant conflicts of interest to declare.
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2006, The American Society of Hematology
2006
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