Abstract
Recipient and donor dendritic cells (DC) initiate acute graft versus host disease after allogeneic hematopoietic stem cell transplantation and activated DC predict for severe disease. Using a differential display technique, we isolated the cDNA for an adenosylhomocysteine hydrolase-like protein 1 (AHCYL1), a novel intracellular protein with ~50% protein identity to adenosylhomocysteine hydrolase (AHCY) and showed that it was upregulated in activated human DC (
Disclosures: The host institution (MMRI) owns the IP associated with this project. The MMRI staff may indirectly benefit long term from commercialization of the IP. There are no current commercial arrangements in place. Pfizer provided non-commercially tied funding to this project previously but have no current interest.
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