Abstract
Factor XI (FXI) binds to high affinity sites on the surface of thrombin-stimulated platelets where it is efficiently activated by thrombin. We have previously shown that FXI binding to thrombin-activated platelets is mediated by residues in the FXI Apple 3 (A3) domain interacting with leucine-rich repeat sequences within the NH2-terminal globular domain of glycoprotein (GP) Ibα (
J. Biol. Chem.
277
:1662
–1668, 2002
J. Biol. Chem.
279
:45470
–45476, 2004
J. Biol. Chem.
279
:49323
–49329, 2004
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2005, The American Society of Hematology
2005
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