Abstract
Recently, in an effort to reduce the transplant related mortality, AHCT with reduced intensity conditioning (RIC) have been developed. It has been reported that patients receiving RIC from an ABO-mismatched donor had more transplant-associated complications compared to ablative AHCT (
BMT
2001
;28
: 315
Transfusion
2002
; 42
:1293
Transfusion
2003
; 43
: 1153
BMT
, 2001
;28
:315
Table
Conditioning . | Ablative . | Reduced Intensity . | |
---|---|---|---|
Source (patients) | PB (n=10) | BM (n=10) | PB (n=10) |
Gender (M/F) | 2/8 | 6/4 | 5/5 |
Median age (range) | 34 (16–45) | 31 (17–46) | 33 (21–47) |
Diagnosis | CML (2), AML (7), other (1) | CML (2), AML (6), other (2) | CML (4), AML (1), other (5) |
ABO-incompatibility | |||
Major | 5 | 6 | 5 |
Minor | 5 | 4 | 5 |
Delayed type hemolysis | 5 (50%) (22,23,55,90,120) | 2 (20%) (18,27) | 4 (40%)(20,130,165,188) |
RBC transfusion (100 days) | 3 (0–15) | 4 (0–10) | 5 (0–10) |
Median days of the independence from pRBC | 7 (0–31) | 18 (0–41) | 7 (0–28) |
Median follow-up (days) | 195 (90–538) | 194 (63–467) | 200 (51–511) |
Acute GVHD (grade II–IV) n (%) | 3 (30%) | 4 (40%) | 4 (40%) |
TRM 100, n (%) | 1 (%10) | 1 (%10) | 1 (%10) |
Conditioning . | Ablative . | Reduced Intensity . | |
---|---|---|---|
Source (patients) | PB (n=10) | BM (n=10) | PB (n=10) |
Gender (M/F) | 2/8 | 6/4 | 5/5 |
Median age (range) | 34 (16–45) | 31 (17–46) | 33 (21–47) |
Diagnosis | CML (2), AML (7), other (1) | CML (2), AML (6), other (2) | CML (4), AML (1), other (5) |
ABO-incompatibility | |||
Major | 5 | 6 | 5 |
Minor | 5 | 4 | 5 |
Delayed type hemolysis | 5 (50%) (22,23,55,90,120) | 2 (20%) (18,27) | 4 (40%)(20,130,165,188) |
RBC transfusion (100 days) | 3 (0–15) | 4 (0–10) | 5 (0–10) |
Median days of the independence from pRBC | 7 (0–31) | 18 (0–41) | 7 (0–28) |
Median follow-up (days) | 195 (90–538) | 194 (63–467) | 200 (51–511) |
Acute GVHD (grade II–IV) n (%) | 3 (30%) | 4 (40%) | 4 (40%) |
TRM 100, n (%) | 1 (%10) | 1 (%10) | 1 (%10) |
Author notes
Corresponding author
2005, The American Society of Hematology
2004
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