Abstract
Cyclin D1 is an essential regulator of cell cycle progression. Over-expression of cyclin D1 is associated with tumorigenesis both in solid cancers and in hematological malignancies such as mantle cell lymphoma (MCL), hairy cell leukemia and multiple myeloma (MM). The CCND1 gene coding for cyclin D1 exhibit an A/G polymorphism at the nucleotide 870 which is responsible for the generation of an alternative splice variant called form b. The cyclin D1b is identical to the typical form a, except in the C-terminal part. The cyclin D1b has lost the PEST domain responsible for protein degradation and the threonine 286, the site of phosphorylation by the glycogen synthase kinase-3 essential for the nuclear export. Cyclin D1b has been recently described as a nuclear oncogene (
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