Topics:
graft-versus-host disease, chronic

We realized recently that the regimen described for the administration of calcineurin inhibitor for treatment of chronic graft-versus-host disease (GVHD)1  is discrepant from current practice. Previously, we used an alternate-day regimen of calcineurin inhibitor administration,2,3  but we now administer cyclosporine or tacrolimus twice daily for treatment of chronic GVHD. Although results with the 2 regimens have not been formally compared, this change was based primarily on pharmacokinetic considerations.

1
Vogelsang GB. How I treat chronic graft-versus-host disease.
Blood
.
2001
;
97
:
1196
-1201.
2
Sullivan KM, Witherspoon RP, Storb R, et al. Alternating-day cyclosporine and prednisone for treatment of high-risk chronic graft-v-host disease.
Blood
.
1988
;
72
:
555
-561.
3
Koc S, Leisenring W, Flowers MED, et al. Therapy for chronic graft-versus-host disease: a randomized trial comparing cyclosporine plus prednisone versus prednisone alone.
Blood
.
2002
;
100
:
48
-51.
Copyright © 2003 by The American Society of Hematology
2003
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