A case of dual sensitization to the rh'' (E) and hr' (c) factors which was detected antenatally has been presented.

The rh'' (E) antibodies probably were caused by a previous blood transfusion which may also have been responsible for the initial stimulation to the hr' (c) antibodies. The subsequent hr' (c) antibodies can be attributed to the hr' (c) factor present in the patient’s three children.

In this study the enzyme-treated red blood cell and the antiglobulin tests were more sensitive than the plasma-albumin test in the detection of the antibodies.

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