The effects of cortisone and hydrocortisone on the levels of thoracic duct lymphocytes have been studied in normal and hypophysectomized rats under standardized conditions. It is shown that:

1. Four hours after its administration, hydrocortisone causes a marked thoracic duct lymphocytopenia, the effect being even more marked in hypophysectomized than in normal rats.

2. At comparable dose levels, hydrocortisone is demonstrably and significantly more effective in producing a thoracic duct lymphocytopenia than is cortisone.

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© 1952 by American Society of Hematology, Inc.
1952
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