Serologic Properties of a Cold Hemolysin and an Acid Hemolysin Occurring in a Case of Syphilitic Paroxysmal Cold Hemoglobinuria

E. T. PETERSON, A.B.,

E. T. PETERSON, A.B.

1Department of Serology and the Laboratory Service, Wadsworth Hospital, Veterans Administration Center, Los Angeles, Calif.

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R. L. WALFORD, M.D.

1Department of Serology and the Laboratory Service, Wadsworth Hospital, Veterans Administration Center, Los Angeles, Calif.

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Blood (1952) 7 (11): 1109–1116.

https://doi.org/10.1182/blood.V7.11.1109.1109

Abstract

1. Two apparently separate hemolysins observed in a case of syphilitic paroxysmal cold hemoglobinuria are described.

a. One hemolysin (cold hemolysin) is that responsible for the Donath-Landsteiner reaction.

b. The other (acid hemolysin) is a thermolabile antibody requiring a lowered pH for the production of hemolysis.

2. Review of the literature indicates that a similar acid hemolysin may have been encountered in other reported cases of this disease.

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1952